#hla-dr4

[good-photo-man]

류마티스 관절염의 습격

1. 면역계가 이상해지면 류마티스 관절염 날씨에 따라 관절염 통증이 심해지는 이유

보통 공기의 기압과 관절 내의 기압은 비슷한 상태로 유지된다. 날씨에 따라 공기의 기압이 변하면 관절 내의 기압은 유지되면서 기압차가 생기게 되기 때문이다.

류마티스 관절염의 발생

류마티스 관절염은 다발성 관절염을 특징으로 하는 원인 불명의 만성 염증성 질환으로 초기에는 관절을 싸고 있는 활막에 염증이 발생해서 점차 주위 연골과 뼈로 염증이 퍼져 관절의 파괴와 변형을 발생시킨다. 관절 뿐 아니라 빈혈, 건조증, 피하결절, 혈관염, 피부궤양 등 전신을 침범할 수 있다.

퇴행성 관절염은 관절을 많이 쓰면서 관절과 관절 안의 연골이 마모되어 퇴행성 변화로 인하여 생긴다. 반면, 류마티스 관절염은 자가면역 현상이 주요 기전으로서,…

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[healthwithtips]

Inflammatory leg pain - Inflammatory diseases

Pathophysiology A foreign stimulus causes the body to mount an inflammatory reaction to maintain its integrity. When an organism or foreign protein penetrates the body surface, a series of host responses occurs. The inflammatory exudate containing immunoglobulin, complement components and other... Inflammatory leg pain - Inflammatory diseases

[cfsfmmcsandrelatedstudies]

Importance of HLA & Ancestry: "Individuals of Celtic ancestry are claimed to be at greater risk of skin cancer than non-Celts," "HLA-DR4 is known to be associated with an increased risk of both basal cell carcinoma and malignant melanoma and its increased frequency in Celts may be an independent risk factor for skin cancer in addition to skin type." (Long et al.)

[cfsfmmcschirps]

Great Study: Hypersensitivities & The Importance of HLA In atopic patients, most whom had asthma, HLA-DR4 and/or HLA-DR7 alleles,"were present in 42.6% of the patients and in only 2.4% of the healthy controls. These results confirm a previous study of a group of polysensitized atopic patients, which showed that DR4 and DR7 alleles were rare in healthy control subjects and frequently observed in atopic subjects with or without concomitant asthma." (Senechal, H. et al.) (HLA-DR4 has been found to be increased in some chronic fatigue syndrome and fibromyalgia studies but not others. It was increased in a CFS cohort with evidence of viral reactivation.)

[cfsfmmcsandrelatedstudies]

Great Study: Hypersensitivities & The Importance of HLA In atopic patients, most whom had asthma, HLA-DR4 and/or HLA-DR7 alleles,"were present in 42.6% of the patients and in only 2.4% of the healthy controls. These results confirm a previous study of a group of polysensitized atopic patients, which showed that DR4 and DR7 alleles were rare in healthy control subjects and frequently observed in atopic subjects with or without concomitant asthma." (Senechal, H. et al.)

[cfsfmmcsandrelatedstudies]

CFS & FM HLA Point To Potential Subgroups

"HLA genes also have the highest relative risk for autoimmune diseases. Three haplotypes, that is, HLA-DR2DQ6, DR4DQ8, and DR3DQ2, account for HLA association with most autoimmune diseases." (Mangalam et al.) http://www.ncbi.nlm.nih.gov/pubmed/23293357 1) HLA-DQ6 was increased in a USA CFS cohort (with sleep abnormalities) and may be increased in English CFS cohorts. It has been associated with risk of narcolepsy and protection from some endocrine diseases. http://www.ncbi.nlm.nih.gov/pubmed/20230458 & http://www.ncbi.nlm.nih.gov/pubmed/16049290 2) HLA-DR4 was increased in a USA CFS cohort & a USA FM cohort it has been associated with endocrine diseases, including Hashimoto's thyroiditis with anti-TPO. It has also been associated with dilated cardiomyopathy. http://www.ncbi.nlm.nih.gov/pubmed/3491715 3) HLA-DR3 has been associated with endocrine diseases, including Hashimoto's thyroiditis with anti-Tg. Since the HLA found in different CFS cohorts are not just different but often confer the opposite results (i.e. risk of a disease vs protection from that disease), the implication is they may be looking at different subgroups. -Laurie

[cfsfmmcsandrelatedstudies]

HLA: One of the Most Important Tests My Family Ever Got

In my family, in addition to my own illnesses (CFS, MCS, Hashimoto's thyroiditis) my mom had developed dilated cardiomyopathy that had slipped into heart failure, had a lupus like reaction to her heart medicine, hydralazine, and was being advised about putting in a pacemaker. Her reaction to Hydralazine was a huge clue in that adverse drug reactions(ADR) to Hydralazine have been widely studied. There were multiple factors associated with risk of having a reaction: female gender, being a NAT2 (a metabolizing enzyme) slow acetylator, and being HLA-DR4 positive. HLA-DR4 had also been associated with dilated cardiomyopathy, Hashimoto's thyroiditis, a poorer response to EBV, and according to some studies, CFS. My mom and I asked to be tested for HLA-DR4 and were positive. My test further looked at specific HLA-DR4 alleles. Once we knew our HLA, it led us to the right medication for mom and the high affinity IgE receptor autoantibody test for me. While HLA are only associated with risk of developing certain diseases or ADR and couldn't tell us for certain what we might have or might get, this test was able to offer us valuable clues. -Laurie