Drugs are a Fairly new Phenomenon
they can only be made in a laboratory
drugs like Methamphetamines, codeine, MDMA, heroin, Morphine, Vicodin, LSD, cocaine or any other viable prescription medicine is only made using a Laboratory
Naturally available plants are fairly common phenomenon, Tobacco, Peyotes, Cactuses, Marijuana, Mushrooms, special Herbs and Spices, they've always been available in the Nature and people know if they are used as "Ingredients" will get them High
But the Datura Flower is a Class 2 Poisonous plant, even if Inhaled or consumed to an extent will cause Heart Failure and or sometimes cause a Brain stroke and should be considered Criminal to use on people, It' like getting a snake bite to get high.