The Science Research Manuscripts of S. Sunkavally, p 538.
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The Science Research Manuscripts of S. Sunkavally, p 538.
Bacteria killers: Microbial murder mystery solved
Immune cells called “killer cells” target bacteria invading the body’s cells, but how do they do this so effectively? Bacteria can quickly evolve resistance against antibiotics, yet it seems they have not so readily been able to evade killer cells. This has caused researchers to become interested in finding out the exact mechanism that killer cells use to destroy bacterial invaders.
Although one way that killer cells can trigger bacterial death is by inflicting oxidative damage, it has not yet been at all understood how killer cells destroy bacteria in environments without oxygen.
Now, for the first time, researchers have caught killer cells red-handed in the act of microbial murder, observing them as they systematically killed three strains of microbes: E. coli and the bacteria responsible for causing Listeria infection and tuberculosis. The process inflicts bacterial cell death regardless of whether the environment contains oxygen or not.
Their findings, published in Cell, reveal that killer cells act methodically, shooting deadly enzymes into bacteria to “program” a complete internal breakdown and cell death.
The researchers, from Boston Children’s Hospital, the Wistar Institute and the University of Michigan (U-M), used an equally systematic approach to make the discovery.
“We took three bacteria that are very different — and to see which proteins were destroyed by killer cells — we measured their protein levels before, during and after they were attacked,” says Judy Lieberman, MD, PhD, of Boston Children’s Program in Cellular and Molecular Medicine (PCMM), who is co-senior author on the study.
The Scientific Research Notes Of S. Sunkavally. Printed Part, Page 424.
Dates unclear, but certainly between. 2006-2012.
The Scientific Research Notes of S. Sunkavally (years:2002-2011).
4303-4305.
The scientific Research Notes Of S. Sunkavally (years: 2002-2011).
1931-1933.
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(via Image of the Week: Killer T Cells Caught on Camera)