If I have a creature with indestructible that takes what would otherwise be lethal damage, and then later in the same turn loses that ability, does it die?
Yes.
Damage stays marked on creatures until the cleanup step. If a creature loses indestructible while having lethal damage already marked on it, it will die the next time state-based actions are checked.
It won’t die if it previously took damage from a source with deathtouch in the turn, though, as the check for deathtouch damage only applies to the next time state-based actions are checked after the damage is dealt.















