#myeloma

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The decision to undergo bone marrow transplantation (BMT) in a lymphoma patient is highly personalized and depends on several key factors:

• Histological Subtype: The specific form of lymphoma greatly influences treatment choices. For example, aggressive diffuse large B-cell lymphoma (DLBCL) or refractory Hodgkin lymphoma may require BMT.

• Disease Stage: The stage at the time of diagnosis plays a crucial role. BMT is often considered for advanced-stage lymphomas or those that have recurred after initial treatments.

• Response to Previous Therapies: Patients who do not achieve remission or experience a recurrence after traditional therapies may explore BMT as a treatment option.

• Age and Overall Health: The patient's age and general health significantly impact their ability to withstand the demanding BMT process.

• Donor Availability: In the case of allogeneic stem cell transplantation (allo-SCT), locating a compatible donor, typically a sibling or a well-matched unrelated individual, can be a complex undertaking.

A bone marrow transplant can be recommended in other medical conditions besides lymphoma, like leukemia, aplastic anemia, thalassemia, myeloma, and sickle cell disease. You can choose to undergo a bone marrow transplant from some of the best hospitals in Delhi. The cost of bone marrow transplant in Delhi will vary depending on the type and severity of condition being treated and the type of bone marrow transplant being performed.

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In a Bind

Multiple myeloma is a blood cancer affecting plasma cells, white blood cells that produce antibodies, causing them to multiply abnormally in the bone marrow. Right now, only half of patients can expect to survive five years after diagnosis, so better treatments are sorely needed. Promising targets include fatty acid-binding proteins (FABPs), a multi-functional family of proteins that can pick up lipids, involved in a variety of processes. A recent study found that cultured myeloma cells (pictured, their nuclei in blue) expressed high levels of one member in particular, FABP5 (in red); blocking it reduced cell proliferation, while patients with higher FABP5 levels tended to experience worse outcomes. Inhibiting FABPs more broadly appeared even more effective, improving survival in some mice with myeloma. To build on these results, further research needs to investigate why not all mice responded so well, and whether inhibiting FABPs would be safe and effective in humans.

Written by Emmanuelle Briolat

Image from work by Mariah Farrell and colleagues

Center for Molecular Medicine, Maine Health Institute for Research, Scarborough, ME, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, March 2023

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PET Scan for Multiple Myeloma: Diagnosis and Staging

Multiple Myeloma is a type of cancer that affects plasma cells in the bone marrow. Plasma cells are a type of white blood cells that produce antibodies to fight infections. When these cells become cancerous, they produce abnormal proteins that can cause various health problems, such as bone pain, anemia, kidney problems, and infections.

Early diagnosis and proper staging of multiple myeloma are crucial for effective treatment and improved outcomes. One of the most effective diagnostic tools for multiple myeloma is a PET (positron emission tomography) scan. In this blog post, we will discuss the role of PET scan in the diagnosis and staging of multiple myeloma.

Uncover multiple myeloma with PET scans: Diagnosis and staging explained

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My mom and I are both Multiple Myeloma widows so we are participating in the Multiple Myeloma March on August 14, 2021 (organized by Myeloma Canada). I would really appreciate it if you would consider making a tiny donation to help us reach our modest fundraising goal. 

Everyone who donates will be entered into a random draw to win one of four Martin & Bosco calendars for 2022 (Canadian & international shipping is included). My mom selected the thirteen photos so it's a Mom's Choice edition of the calendar. We’ll also mail you a colourful Martin and Bosco postcard with a personal note as a thank-you because it’s fun to receive “real” mail.

An earnest shout-out to my Multiple Myeloma followers! I don’t offer you much content on this crazy blog but you know I understand how brutal this cancer is on a loved one. I will fundraise for Myeloma Canada for the rest of my life. I'll never have the opportunity to apologize to Martin for not being able to help him; his suffering was inhumane. Fundraising is a way for me to make that weight a bit less heavy.

Here’s the link to donate.

Thank-you.

[bloodcanceruncensored]

Acute or chronic which is worse? What does AML ALL CLL CML NHL DLBL mean?

Acute or chronic blood cancer - which is worse? What does AML ALL CLL CML NHL DLBL mean?

When you walk out of that first diagnosis appointment all some people remember is the word “lymphoma”, “leukemia” or “myeloma”. But to understand what is actually wrong with you if you have lymphoma or leukemia the real question is which type. You may also have been given a three letter acronym or abbreviation that indicates what variety of blood cancer you have.  At the end of this article is a…

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Images SS2136664 & SS2770235 (Multiple Myeloma)

Multiple Myeloma is a cancer that forms in a type of white blood cell called a plasma cell.

Plasma cells mature from B lymphocytes in the bone marrow and produce antibodies used to fight infections. Sometimes various gene mutations can alter this process, causing a proliferation of plasma cells and overproduction of antibodies.

Learn More About Multiple Myeloma

Malignant plasma cells in bone marrow can interfere with the production of normal blood cells and lead to bone lesions, osteoporosis, pathological bone fractures, and hypercalcemia.

The skull x-ray (top) is of patient with multiple myeloma, showing typical appearance of holes.  As the disease progresses, it can lead to bone pain, thinning bones and broken bones.

Images above © Science Source