This is always hard, because each book fills a book-sized gap in the world. Nonetheless, it's that time of year for making lists, and here's mine:
(Bear in mind that The Bone Clocks, Station Eleven, and The Laughing Monsters are still in my queue.)
The Book of Strange New Things by Michel Faber.
Cementville by Paulette Livers.
An Untamed State by Roxane Gay.
Every Day Is for the Thief by Teju Cole.
A Curse on Dostoevsky by Atiq Rahimi.
Kinder Than Solitude by Yiyun Li.
The Painter by Peter Heller.
The Antiquarian by Gustavo Faveron Patriau.
The Monster's Wife by Kate Horsley.
Best Science Fiction & Horror of 2014
(Bear in mind that I haven't read John Scalzi's Lock In yet, and I'm eliminating all Stephen King novels from competition because he doesn't need any help from anybody.)
Afterparty by Darryl Gregory
Broken Monsters by Lauren Beukes.
The Happier Dead by Ivo Stourton
Hollow World by Michael J. Sullivan
The First Fifteen Lives of Harry August by Claire North.
The Boy Who Drew Monsters by Keith Donohoe.
Bathing the Lion by Jonathan Carroll.
The Killer Next Door by Alex Marwood.
The Half Has Never Been Told: Slavery and the Making of Modern Capitalism by Edward E. Baptist.
Stringer: A Reporter's Journey in the Congo by Ajan Sundaram.
Demon Camp: A Soldier's Exorcism by Jennifer Percy.
The Short and Tragic Life of Robert Peace: A Brilliant Young Man Who Left Newark for the Ivy League by Jeff Hobbs.
Fire Shut Up in My Bones: A Memoir by Charles M. Blow.
Little Failure: A Memoir by Gary Shteyngart.
Illegal: Reflections of an Undocumented Immigrant by Jose Angel N.
Friday Was the Bomb: Five Years in the Middle East by Nathan Deuel.
The Trigger: Hunting the Assassin Who Brought the World to War by Tim Butcher.
Charity & Sylvia: A Same-Sex Marriage in Early America by Rachel Hope Cleves.