#phosphorylation

[wtf-fun-factss]

New research on the body's liver response explains why we're triggered by food. Click to read the full fact.

[whats-in-a-sentence]

The systemic production of proteinase inhibitors in young tomato plants is triggered by a complex sequence of events (Figure 23.20):

Wounded tomato leaves synthesize prosystemin, a large (200 amino acids) precursor protein.

Prosystemin is proteolytically processed to produce the short (18 amino acids) polypeptide DAMP called systemin.

Systemin is released from damaged cells into the apoplast.

In adjacent intact tissue (phloem parenchyma), systemin binds to a pattern recognition receptor on the plasma membrane.

The activated systemin receptor becomes phosphorylated and activates a phospholipase A2 (PLA2).

The activated PLA2 generates the signal that initiates JA biosynthesis.

JA is then transported through the phloem to systemic parts of the plant by an unknown mechanism.

JA is taken up by target tissues and activates the expression of genes that encourage proteinase inhibitors.

"Plant Physiology and Development" int'l 6e - Taiz, L., Zeiger, E., Møller, I.M., Murphy, A.

[soupismyfavouriteword]

when i took bio i meant human physiology not some non-cyclic photophosphorylation shit😭😭😭😭😭😭😭😭

[bpod-bpod]

Features of Films

Living in a tight-knit community can provide safety and support. Bacteria find this too, and huddle together to form dense biofilms, which increase their survival and infectious potency. These films are glued together by a sugary slime called exopolysaccharides, without which the structure begins to fall apart. A new study has revealed a key factor in the production of this material in cholera biofilms (Vibrio exopolysaccharide, VPS). By adjusting the amount to which a particular enzyme attaches to and removes phosphate (dephosphorylation), the researchers changed the structural integrity of the biofilms (pictured, in several experiments). The production of VPS was directly regulated by the phosphorylation status, revealing a potential weakness that treatments could target to help prevent cholera settling in. Furthermore, these systems are similar among many bacteria that produce equivalent biofilms, meaning the insights could help tackle a wide range of diseases.

Written by Anthony Lewis

Image from work by Carmen Schwechheimer and colleagues

University of California—Santa Cruz, Santa Cruz, CA, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in PLOS Pathogens, August 2020

You can also follow BPoD on Instagram, Twitter and Facebook

[eka-mark]

After reading Dan Urry’s work on what he calls the apolar-polar repulsive free energy of hydration, I am less puzzled by biology’s obsession with phosphorylating and dephosphorylating proteins.

Basically, due to the competition between hydrophilic and hydrophobic surfaces for hydration, the extremely hydrophilic phosphate causes nearby hydrophobically associated regions to dissociate. Contrariwise, removing a phosphate group encourages nearby hydrophobic regions to associate (i.e. stick together). (This only makes sense in light of the fact that hydrophobic hydration is enthalpically favorable but entropically unfavorable.)

So (de)phosphorylating a protein at the right site can selectively, reversibly, and locally add or subtract stickiness, causing a conformational change.

[cytgen]

Bioinformatical View on the Contribution of MAST/IRE-Dependent Phosphorylation in the Tubulin Code - Cytology and Genetics

Abstract Protein kinases represent one of the largest eukaryotic enzyme superfamilies. However, only a few can directly phosphorylate tubuli

Abstract Protein kinases represent one of the largest eukaryotic enzyme superfamilies. However, only a few can directly phosphorylate tubulin and contribute to the modulation of the “tubulin code.” The authors previously confirmed the structural and functional homology of the plant protein kinase IREH1 and members of the mammalian MAST kinase family. Their participation in the regulation of the microtubule system in plant and animal cells was also experimentally confirmed. At the same time, the direct contribution of MAST/IRE to the “tubulin code” remains unclear. In the current study, based on bioinformatical and structural biology methods, the possibility of such an interaction was evaluated. The target sites of MAST/IRE-phosphorylation of tubulin were predicted based on similarity to the generalized specific profiles. Two potential MAST/IRE specific sites, conserved in human and Arabidopsis tubulins were selected: Thr73 (80) exists in most isotypes of α-tubulin and Ser115 was found in the majority of human and plant isotypes of β-tubulin. It was predicted that phosphorylation of the first site can affect the assembly of α/β-tubulin heterodimer, and phosphorylation of the second may affect the interaction between neighboring protofilaments of microtubules. The last site Ser433, was found in both γ-tubulin isotypes of A. thaliana, but it was absent in mammals. The external position of Ser433 in plant γ-tubulin allows for suggesting that phosphorylation of this amino acid can affect the structure of the γTuRC complex but it does not affect inner contacts of γTuSC and their interaction in the ring.

[pharmaguidelines]

Phosphorylation:Metabolic Pathway

Phosphorylation: The Powerhouse of Cellular Energy In the bustling world of cells, energy is the driving force behind every process, from building proteins to transporting nutrients. And one of the most crucial players in this energy-generating game is phosphorylation. What is Phosphorylation? Phosphorylation is the process of adding a phosphate group (PO43-) to a molecule. This process can…

View On WordPress

[gillianthecat]

ok but this sentence was on another diagram she shared:

"cells constantly replace their ATP by whacking a spare phosphate onto ADP"

how delightfully informal! i'm guessing this is British English? but even there I can't imagine this is typical academic textbook language, right? the rest of the sentence was the normal dry explanation.