I know this is such a wierd turn from something as lore heavy and important as Zarakis mum into a basically an ask about my crackship
But you have given me some thoughts, I could be misremebering but I believe she was present as a Soul Reaper when it happend.
Meninas x Isane
With the extra context of Isane being there when the whole Quincy purge was going down. I know it's such a wierd thing to add to a relationship but Isane is such like a truly good girl otherwise not counting this not so fun fact. And from Menis whole attitude, she doesn't seem the type to care? Like Bambi and Candice seemed vengeful of the Shinigami in their actions, Giselle may also have been, however rather seemed to be in her in her own sort of mental wonderland and acted horrifically, Liltotto also seemed somewhat detached but appeared to hold many ambitions of power. But Meninas seemed like she really was just flowing with the ocean going through the motions of being a Quincy knight, doing her job killing and being killed. Like I don't know, there's something there but I've no idea how to properly word or construct it.
Maybe I'm misinterpreting your comment (my meds kicked in), but Isane wasn't there during the Quincy purge. She's from a younger generation (my thoughts is she's contemporary to Rangiku and Gin, and older than Hisagi)
Whether she was aware of the purge being the gotei's doing or not, I can't really say because at some point Yamamoto removed that part of history from the academy's curriculum, and judging by some of the younger officers' reactions, it seems a great deal of them didn't know why they were being invaded (hell, in the story proper, they didn't know what a Quincy was at ALL until Rukia met Uryu and asked Urahara about his origins)
And as for Meninas, she also comes from a future generation. Unfortunately there's not enough info on the Quincy faction, on how time passes for them within the shadows of Soul Society/Wandenreich, let alone at what point was Meninas recruited to the Sternritter, or if she was even born in the Wandenreich, or if she got picked up from some settlement outside like Jugram and Bazz-B were.
All I can say for certain is: she definitely knew what went down between shinigami and Quincy during the first Blood War, definitely learned about the purge, but didn't know about Yhwach's true goals and nature.
Plus, the way the Sternritter works in a very militant, despotic, dog eat dog type of way. Each member acts as a surveillance unit to watch for any bad behavior from their companion and immediately report anomaly/treasonous action; mistakes are paid for with lives, the schrift users get picked personally by Yhwach, either by Pious Means like Äs Nödt was (as pious as a tyrant like Yhwach can be, anyway. A death sentence disguised as a second chance at life), or by force like Bazz-B was (forced to watch his home burn, become alienated from his closest and only friend and basically dehumanize him so bad until he's begging to join the ranks with the promise of a chance to kill the man that ruined him as bait.)
We're not told how the femritters were recruited, but it's certain they had no choice in the matter and, like all the rest of their compatriots, they had to make the best of their situation with what they had at hand.
In a Q&A session, Kubo couldn't really call the femritters friends because the sentiment depends on what each of them thinks of the others at the moment. They're the closest thing to a team within the Sternritter, but they're still terribly imbalanced because they won't hesitate to be at each other's throats.
Meninas is perhaps the chillest of the 5, and though she plays into the role of dumb muscle, she's actually someone that only wants some peace and quiet (as shown by the Brave Souls side stories). She dislikes it when people talk about her behind her back, HATES it when they underestimate her (Rukia was at the receiving end of her ire), and does show a level of camaraderie for her fellow femritters as she helps a wounded Candice around. And she was well liked enough by Liltotto as the latter cannibalizes Pepe for brainwashing her.
The attitude difference between Isane and Meninas is that, while both can't afford to stop and think about their situations during the war, Isane's investment in keeping casualties to a minimum not only stem from her duty as the current leader of the 4th, but also because many of those wounded and dead are her friends and companions. Meanwhile, Meni has to rain destruction cause that's her job, and if she doesn't, she's gonna get horribly punished by her own faction.
We don't know what level of angst Meni feels herself since she's never shown individually, but being a Quincy under Yhwach's command is already a miserable position to be in.
And since they're on opposite ends of the war, whatever interaction they could have had would have been cutting and brief.