#psilacetin

[drugusersbible]

It is widely stated that 4-ACO-DMT produces an experience which is identical to psilocybin, and this was also my own experience. Something to bear in mind are the varying doses quoted for full immersion (the "Mckenna experience"), even though the chemical is generally considered to be relatively benign.

www.DrugUsersBible.com

[anc1en7]

I'm a 41 yo man. Last night, I tripped for the first time in my life on 100 mg of 4-aco-dmt. I experienced ego loss multiple times.

Very good read :)

TIL 4-AcO DMT = Psilacetin

[paradoxb3ar]

(GUIDE]Chemistry, Reactivity, Stability of ester bonds (4-AcO-Tryptamines)

Esters are condensation products of acids (can be inorganic or organic) with alcohols (at least one hydroxyl group —> –OH available). Organic acids all have a COOH-group (as you can see in the first image under examples). Condensation means that a small molecule leaves and two big molecules merge. When an ester is formed, water (= H2O) leaves and connects the acid and the alcohol. Examples for acids, alcohols and esters are given below: Synthesis: How is an ester actually synthesized in the lab? The basic reaction for an ester formation is: R1COOH + R2OH —> R1COOR2 + H2O This means we can easily get more of our desired ester by taking away the water from the reaction thereby forcing the equilibrium to the right side. This is achieved by catalysts like concentrated sulfuric acid which is very hydrophilic and wants to dilute itself by taking water. Other drying agents can also be used to bind the water. Another method would be distilling the water off, therefore also removing it from the mixture. The alcohol can be used in excess so that we get more of our ester too. Another method for synthesis is the use of anhydrides or chlorides of the corresponding acids. In this case one equivalent of HCl (is a gas so it removes itself from the mixture) or acid is formed in the reaction (see picture below). This is a very easy route, acid chlorides and anhydrides can be nasty to work with but sulfuric acid destroys a lot of organic molecules so this is a pretty straightforward way to go. Stability: An esterification is a very reversible reaction so esters aren’t the most stable molecules. They can be cleaved in acidic and basic environments. The reaction schemes for these reactions are given below: Reactivity: Because the –OR group on the ester (alkoxy-group) is a relatively good leaving group it is easily cleaved by OH- (hydroxyl) as we saw before and by amines and ammonia yielding amides. Example: 4-AcO-DMT: Most of you will probably be interested in the application on RCs. That is what this point is all about. I will try to explain and find the reason why 4-AcO-DMT has so many problems with degradation. First of all: we have learned that the ester can be cleaved by acidic and basic conditions (in water of course). Now imagine you have a little bit of 4-AcO-DMT freebase lying around. All around in the atmosphere there is air which carries little amounts of H2O. Now when the 4-AcO-DMT absorbs a little bit of that water it could happen that a single molecule takes the water and reacts to Psilocin and acetic acid. Well, guess what, acetic acid is an acid and as soon as one molecule is cleaved the environment in the vial gets a little more acidic. This, of course, opens more ester bonds setting free even more acetic acid. The reaction can catalyze itself. Now that wouldn’t be much of a problem but there is more. Freebase 4-AcO-DMT degrades very fast because the amine group is a freebase and not a salt. Why that matters? If you have 4-AcO-DMT.Hydrochloride then the amine group can’t react anymore, it can’t get loose of the hydrochloric acid, but when it’s in the freebase form it can react with the oxygen in the air forming 4-AcO-DMT-N-Oxide. This stuff has oily properties and is difficult to handle but should still be good for some research. If you want to convert the 4-AcO-DMT-N-Oxide or Psilocin-N-Oxide into its freebase form you can do this: Dissolve in acetic acid (about 30 weight%). Add about 1:1 in weight of Zinc to the solution (weight of your initial Tryptamine of course). Stirr the solution every once in a while for 2 hours. Filter off the zinc particles and keep the liquid, discard what’s in the filter. Add saturated sodium carbonate solution (about 10 ml for 0.5g 4-AcO-DMT). If it stops fizzing add another 10-20 ml of saturated sodium carbonate solution. Now something should precipitate out of solution. Add 50 ml Naphtha (or any saturated hydrocarbon-mixes under the C10 range), shake a few times and separate the Naphtha and the water layer. Do this 2-4 times. Some white stuff in the water will NOT dissolve in the Naphtha, this is fine. You can evaporate the combined Naphtha pulls or put them in the freezer and see if something precipitates out of there. Afterwards you can transform your Freebase into Fumarate and never have this trouble again<3

If anyone has any questions about any type of Phenethylamines, Tryptamines, Nootropics, etc.. feel free to hit me up, i love sharing, or learning new information.

Man, this post makes me miss my science partner scotty. I really need to get back to writing more stuff like this again.

[committedpsychonaut]

Can you provide and objective opinion on you thoughts of the difference between 4-Aco-DMT and nn-DMT? (if at all possible :P)

I thought about this for some time and I'll give it a shot, it certainly is a difficult question. Psilacetin has a very warm and comfortable body feel. The high is stoning, which puts me in a woozy, dreamlike state. Despite this, the high is also very energetic. On psilacetin, I feel the as though I am a child again, learning about the world for the first time. It makes me want to explore and discover something new. It fills me with wonder and awe, and makes me appreciate my humanity. The experience has a wonderful come up, steady plateau, and a long lasting afterglow. The afterglow period permits ample time to process what occurred, and and allows for integration. I feel as though psilacetin is superior in this aspect.

DMT, on the other hand, is very sedating when I vaporize it. Immediately after inhaling the vapor my muscles completely relax and I lose control of them and lay down. The body buzz is jarring and feels like powerful vibrations radiating throughout your body. Audible buzzing begins and becomes quite loud, it usually sounds mechanical in nature. In contrast to psilacetin, the DMT body load is less warm and "human." It is more synthetic in nature. I had one experience where the fabric of reality tore back and I could see gears and oil pumps working. These machines kept the illusion of reality running, and then my human being became an organic/synthetic hybrid. The afterglow has has a feeling quite like psilacetin for about one hour after, but the experiences themselves are very distinct. 

The experience of smoking DMT is shocking and quite violent when vaporized. The afterglow lasts about 30 mins to and hour, which gives you some time to process, but I don't always feel as though that is adequate for the integration of the experience. DMT throws a lot of psychedelica at you, and doesn't allow you to make much sense of it. Psilacetin feels as though it's guiding you along the way, actively aiding integration of the psychedelic experience.

DMT visuals usually have much more complex geometry. Psilacetin usually makes objects appear as though they are melting. Not as much complex geometry or fractals are present in the psilacetin experience compared to DMT. The two substances have roughly the same level of color enhancement. 

[committedpsychonaut]

thoughts on 4-aco-dmt? personally i'm a big fan of it :)

I am also a fan of psilacetin :D I have posted a few of my experiences with this material and some information on it under the #psilacetin tag. I love the warm body feel the compound provides and the lack of nausea. The compound feels so natural and clean. I would definitely consider it among my top 5 favorite psychedelic compounds :)

[committedpsychonaut]

mind if i ask where you bought your 4 grams or 4-aco-dmt, and how much it cost you?

I just answered a question on sourcing MXE. It should also aid you in your search for 4-AcO-DMT. I paid approximately $300-400 for 4 grams of 4-AcO, I don't remember the exact amount. I would not pay over $120 per gram. 

As stated in the sidebar, I do not provide sources outright for research chemicals or scheduled substances. I have had issues with concern to being badgered unendingly for drug sources which should not be shared/discussed publicly. Not disclosing specific sources publicly protects both the consumer and the supplier from the attention of law enforcement. Please don't take this personally. I can, however, point you in the right direction. I would utilize Safeorscam to check the legitimacy of any vendors that you happen to come across. The site permits users to leave a rating on a scale of 1 to 10 and also written feedback about purchasing experiences. Quite a few trustworthy chemical suppliers can be found simply by utilizing a search engine. I would recommend conducting your search based on IUPAC names of compounds. It might also be helpful to search for IUPAC names coupled with terms such as buy, quantity, and quality to narrow down the results.

There are various RC forums which are quite well known. These sites are closed communities which permit sourcing/vendor discussion. I recommend joining them to read the feedback that customers have left about certain vendors. Vendors are also sometimes active on SoS/RC forums to directly answer questions and address concerns. I would not trust a vendor's claim of a quality product. The 99% quality claim is absolute hearsay unless actual lab results by an independent 3rd party are provided. Don't fall for it, ask a vendor to provide analytical data before making a purchase. It would be wise to invest in a test kit to verify that substances are actually as advertised. Depending on the substance Mecke, Mandelin, Marquis, Simon's, Robadope's, and Elrich reagent tests can be utilized to identify substances with a fair degree of accuracy. I believe Dancesafe and The Bunk Police sell such kits. Please take the time to read as much as possible before continuing any further. Erowid and Bluelight are excellent sources for information concerning harm reduction. This path can be immensely rewarding when you properly respect your mind, your body, and the substances at hand. Failure to do so will not end well. Please exercise caution.

Know your Body. 

Know your Mind.

Know your Substance.

Know your Source.

- Erowid

[committedpsychonaut]

My 4g of 4-AcO-DMT fumarate. Don't let the color fool you, it is not oxidized and it is very potent. Perhaps the best batch I've yet experienced.

[committedpsychonaut]

Last night I had quite an odd encounter with 4-AcO-DMT. I consumed an 18mg capsule of fumarate on an empty stomach although I did not experience effects for over 3 hours. I had absolutely no tolerance as I had not taken a psychedelic in almost 3 weeks. When no effects manifested, I consumed one beer and smoked some cannabis. In the middle of taking a hit, all of the effects from psilacetin came on at once with no warning. For a moment, I was quite convinced that I had just smoked DMT because of the powerful, rushy onset. There was certainly some visual activity, but the experience seemed to begin to decay immediately after the sudden onset. Pupils became dilated after T+3 hours and remained so until approximately T+5 hours. Afterwards I was quite restless and had trouble sleeping until ~T+7 hours. 

It is possible that the small amount of alcohol which I consumed finally allowed the capsule to fully dissolve, but that doesn't quite make sense. I was feeling a moderate tryptamine body buzz and had an elevated mood approximately 30-45 minutes after ingestion. Maybe the alcohol fully kick-started the metabolism of psilacetin? The material which was utilized for this trial was not degraded and had been tested previously with standard results. Odd.