Dec 7, 2017
SC: “...if you are a mitochondriac, this is profound...”
"The dissociation of a deuteron from Asp61 of the c subunit when exposed to the matrix half-channel is likely to be slowed, since it is exposed to the channel for a very short time because of the Brownian motion of the c subunit. This slow dissociation may cause temporary stutter in the rotor. If we were able to observe all ~15000 ATP synthases (Table (Table1)1) in a mitochondrion, we would see a percentage of them stuttering at any given time."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1808445/
via Scott Compton
