Just thinking about some more Janeway and Chakotay stuff, especially regarding their sisters.
(a lot of the following is from beta canon, obviously)
They're both part of a pair of siblings who are pretty different from one another, and both sets of siblings have the following in common:
One sibling grew up doing what was expected of them (Kathryn became a scientist and a Starfleet officer, Sekaya immersed herself in her people's culture and traditions and later became a shaman)
One sibling grew up rebellious and at odds with their family (Chakotay took this to an extreme and joined Starfleet after completely rejecting his culture, while Phoebe took this to a lesser extreme and became an artist.)
One sibling appears to have been largely unattached throughout life (Chakotay doesn't appear to have ever had a particularly serious relationship, and I don't think there's ever been a mention of Phoebe having a partner until the new Janeway biography was released (and I tend to ignore that book)).
But the other sibling has had serious relationships that have ended in tragedy (Kathryn lost Justin in the same crash that killed her father, before losing her relationship with Mark thanks to Voyager. Sekaya meanwhile, lost her childhood sweetheart - Blue Water Dreamer - when he was murdered by Crell Moset)
Both sets of siblings have had conflicts based on their differing outlooks with Chakotay and Sekaya being out of touch for years at one point, and Kathryn and Phoebe never seeing eye to eye on much of anything.
Both sets of siblings appear to have reconciled somewhat following the deaths of their fathers. Phoebe helped Kathryn overcome crippling depression following Edward Janeway's death, while Chakotay returned home and began to follow his peoples' traditions after Kolopak's death.