#singlemolecule

[mysticalpeacenut]

Depixus Wins SLAS2024 Ignite Award for MAGNA Technology - Depixus

[mysticalpeacenut]

Depixus Wins SLAS2024 Ignite Award for MAGNA Technology - Depixus

Paris, France – Interactomics pioneer Depixus has won the prestigious Society for Laboratory Automation and Screening (SLAS) Ignite Award at the society’s annual International Conference and Exhibition in Boston, MA, for their novel MAGNA™ technology. The award coincides with the first showing of Depixus’ ground-breaking MAGNA One™ instrument at the conference.

The Ignite Award recognizes exciting companies providing game-changing technologies for the life sciences. Judged by a panel of experts, participants were scored on excellence in innovation, marketing presence and opportunity, messaging, impact, funding, and balanced leadership.

Depixus was one of just 16 companies selected to participate in the SLAS2024 Innovation AveNEW program – a specially designated area for start-ups and emerging companies within the conference – of which the top eight were shortlisted as finalists for the Ignite Award.

Based on magnetic force spectroscopy, MAGNA One enables  scalable analysis of dynamic biomolecular interactions. This technology is the first to offer direct, simultaneous, and real-time measurements from thousands of individual molecules.

It is particularly useful for exploring challenging targets such as RNA and protein-protein interactions, providing invaluable insights into disease mechanisms and accelerating the development of novel therapeutics.

Depixus CEO Gordon Hamilton says, “We’re thrilled to have won this year’s Ignite Award against such stiff competition and congratulate all the other finalists. This recognition is a great way to celebrate the company we are building, our innovative technology, and its potential to impact the understanding and treatment of diseases where new approaches are urgently needed.”Depixus Wins SLAS2024 Ignite Award for MAGNA Technology, Depixus Chief Commercial Officer Steve Klose added, “The timing of this award aligns perfectly with the launch of our technology access program and commercial rollout of MAGNA One. It’s been an honor to unveil our new instrument to the world at SLAS2024, and we’re excited to see how the scientific community puts it to work to transform research.”

[mysticalpeacenut]

12th February 2024 Paris, France - Depixus CEO Gordon Hamilton Receives The SLAS2024 Ignite Award From Judge Severine Tamas-Lhoustau, CEO Of

Depixus Wins SLAS2024 Ignite Award for MAGNA Technology

Depixus introduces MAGNA™, a groundbreaking technology that utilizes magnetic force spectroscopy to examine biomolecular interactions at the single-molecule level, unlocking a new era in disease research and therapeutic development. MAGNA™ recently won the prestigious SLAS2024 Ignite Award, a testament to its revolutionary potential.

[slimlastforskolins]

Understanding transporter proteins at a single-molecule level -- ScienceDaily

Understanding transporter proteins at a single-molecule level — ScienceDaily

Like a boat helping passengers cross a river, transporters move substances across cell membranes. This process is fundamental to the healthy functioning of cells in life forms from bacteria to humans. The function of these transporters previously had to be inferred from the behavior of hundreds or thousands of them working together. Published today in Nature, new techniques enable the study of…

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Terahertz spectroscopy enters the single-molecule regime Researchers showed that long-wavelength terahertz (THz) spectroscopy can detect motion of single molecules, not just molecular ensembles.

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Observing fluctuations on the single-molecule scale -- ScienceDaily

Visit Now - https://zeroviral.com/observing-fluctuations-on-the-single-molecule-scale-sciencedaily/

Observing fluctuations on the single-molecule scale -- ScienceDaily

Scientists at Tokyo Institute of Technology (Tokyo Tech) have developed a technique for analyzing structural and electronic fluctuations on the single-molecule scale across the metal-molecule interface in an organic electronic device. This technique provides information that cannot be obtained using the conventional method, and it has important implications for devices such as organic solar cells.

The organic electronics field is gaining prominence in both academia and industry as devices such as organic light-emitting diodes and solar cells have multiple advantages over conventional inorganic devices, including much lower potential production costs and broader substrate compatibility. These devices incorporate organic molecules and metal components, and one of the major challenges in this field is understanding the charge transport behaviors across the metal-molecule interface. Recently, break junction techniques were developed, wherein the electric current across a single-molecule junction is measured thousands of times. The measurement results are then analyzed statistically to determine the most probable electrical conductance.

The structural and electronic characteristics of a metal-molecule interface strongly influence the charge transport properties of the single-molecule junction. Further, the metal-molecule interface structures and transport properties fluctuate on the single-molecule scale. Unfortunately, the standard analysis technique of conductance measurement cannot elucidate this behavior sufficiently. Scientists at Tokyo Tech have recently developed a comprehensive method for analyzing these fluctuations. Their technique involves combining two methods: current-voltage measurement through break junction experiments and first-principles simulation. It is worth noting that the developed technique provides a correlated statistical description of the molecular orbital-energy level and the electronic coupling degree across a metal-molecule interface, unlike the standard analysis methods typically employed in this field.

The developed analysis method was applied to various single-molecule junctions, i.e., those of 1,4-butanediamine (DAB), pyrazine (PY), 4,4′-bipyridine (BPY), and fullerene (C60), sandwiched by gold electrodes, and the different molecular-dependent electronic and structural fluctuations were demonstrated. The junctions were stretched by up to 10 nm until breaking during the experiments and simulations in order to identify any structural variations; it was found that the electronic coupling between the electrode and molecule decreases with increased stretching. Further, total energy calculations performed as functions of the stretching distance revealed metastable structures in the structural models.

The developed method provides characteristic information about the simple, low-dimensional, and ultra-small charge transport across the metal-molecule interface, which is relevant to the switching functionality and potential manipulation of transport properties. This novel technique and the information it provides have significant implications for future transport property manipulation in electronic devices featuring organic molecules, such as solar cells and light-emitting diodes.

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[gattaquant]

Many thanks to Sam Lord and UCSF. We do some great measurements and have a good time in San Francisco!