Just like anything and everything, the amount of rest and work during holidays has to be regulated. 🤓®
Talking regulated, let's talk Ca2+ regulation in plasma;
FEW KEY POINTS TO REMEMBER 💭:
~To find out plasma [Ca2+], you use the equation : total = intake - output
~Total [Ca2+] = ECF (half the Ca2+ are bound to plasma proteins while other are free to move across membrane. ≈2.5mM), ICF (free in cytosol, ≈0.001mM. concentrated in mitochondria and SER) and extracellular matrix ((bone) largest Ca2+ reservoir in the form of hydroxyapatite crystals. Can be tapped to maintain plasma [Ca2+]) .
~Intake =Ca2+ ingested + absorbed at small intestine. The Ca2+ is hormonally regulated and only ≈ ⅓ of ingested Ca2+ is absorbed.
~Intake may not match output due to transcellular (regulated) and paracellular (unregulated) movement of Ca2+.
~Output, primarily takes place via kidneys - Ca2+ is primarily filtered at glomerulus and reabsorbed at kidney, hormonal reabsorption takes place at distal nephron and is transcellular.
~Plasma [Ca2+] is controlled by 3 hormones, PTH, Calcitriol (aka Vitamin D3) and Calcitonin.
~Even during holidays, find some time to at least brush up on concepts you struggle with. As important as it is to rest, don't deceive yourself saying you're resting when you know you're just avoiding looking at your books. Rest is needed, too much rest becomes harmful.
