Super Models
Transmitted by ticks, flaviviruses like Kyasanur Forest disease virus (KFBV) and its close relative Alkhurma haemorrhagic fever virus (AHFV) are emerging threats for global health. With a small but growing number of cases, and an expanding range in India and the Middle East respectively, these viruses can cause fatal haemorrhagic fevers, but remain relatively-poorly understood. Typical laboratory animals like mice can be infected with both viruses, but the diseases often manifest very differently compared to human patients. Among primates, rhesus macaques (Macaca mulatta), are largely protected by a protein hindering viral replication, but pigtailed-macaques (Macaca nemestrina) are not. Infecting them with KFBV or AHFV triggers symptoms more consistent with those of humans, with virus particles found in the gut and lymph system (pictured are KFBV particles, in red, in a lymph node). As a model system, this species could help us better understand these viruses, and potentially develop future vaccines.
Written by Emmanuelle Briolat
Image from work by Rebecca M. Broeckel and colleagues
Laboratory of Virology, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Research published in PLOS Pathogens, December 2021
You can also follow BPoD on Instagram, Twitter and Facebook
