#wiv

[rossmarysworld]

[factcheckdotorg]

No Evidence Scientists Received Grant for Changing Opinion on Pandemic Origins, Contrary to Claims - FactCheck.org

Republican Rep. Jim Jordan baselessly suggested that former NIAID director Dr. Anthony Fauci gave scientists one of the grants — worth $9 million — to alter the scientific narrative on how the COVID-19 pandemic started.

[askpredacorp]

As I move forward with the plot (I promise there is a plot), I made this recap to help.

I still encourage you to read this blog from the beginning though.

[ronnienews]

COVID-19

RC

[didanawisgi]

SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2

Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Prion-like domains are critical for virulence and the development of therapeutic targets; however, the prion-like domains in the SARS-CoV-2 proteome have not been analyzed. In this in silico study, using the PLAAC algorithm, we identified the presence of prion-like domains in the SARS-CoV-2 spike protein. Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein, since SARS-CoV-2 was the only coronavirus with a prion-like domain found in the receptor-binding domain of the S1 region of the spike protein. The presence and unique distribution of prion-like domains in the SARS-CoV-2 receptor-binding domains of the spike protein is particularly interesting, since although the SARS-CoV-2 and SARS-CoV S proteins share the same host cell receptor, angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 demonstrates a 10- to 20-fold higher affinity for ACE2. Finally, we identified prion-like domains in the α1 helix of the ACE2 receptor that interact with the viral receptor-binding domain of SARS-CoV-2. Taken together, the present findings indicate that the identified PrDs in the SARS-CoV-2 receptor-binding domain (RBD) and ACE2 region that interact with RBD have important functional roles in viral adhesion and entry.

SARS-CoV-2 Prion-Like Domains in Spike Proteins Enable Higher Affinity to ACE2 (Preprint)

Abstract

Currently, the world is struggling with the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Prion-like domains are critical for virulence and the development of therapeutic targets; however, the prion-like domains in the SARS-CoV-2 proteome have not been analyzed. In this in silico study, using the PLAAC algorithm, we identified the presence of prion-like domains in the SARS-CoV-2 spike protein. Compared with other viruses, a striking difference was observed in the distribution of prion-like domains in the spike protein, since SARS-CoV-2 was the only coronavirus with a prion-like domain found in the receptor-binding domain of the S1 region of the spike protein. The presence and unique distribution of prion-like domains in the SARS-CoV-2 receptor-binding domains of the spike protein is particularly interesting, since although the SARS-CoV-2 and SARS-CoV S proteins share the same host cell receptor, angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 demonstrates a 10- to 20-fold higher affinity for ACE2. Finally, we identified prion-like domains in the α1 helix of the ACE2 receptor that interact with the viral receptor-binding domain of SARS-CoV-2. Taken together, the present findings indicate that the identified PrDs in the SARS-CoV-2 receptor-binding domain (RBD) and ACE2 region that interact with RBD have important functional roles in viral adhesion and entry.

[the-watcher-knights]

Hey Wiv, tell us about yourself!

Wiv: I’m not exciting otherwise.

[factcheckdotorg]

Still No Determination on COVID-19 Origin

Most U.S. intelligence agencies assess a spillover from an animal is most likely the origin of COVID-19, but recent news reports say the Energy Department now favors the lab-leak hypothesis. Online posts wrongly claim this means a lab origin has been confirmed.

[askpredacorp]