The Moustached Prophet @themoustachedprophet - Tumblr Blog

bye.

word-stuck

baawri

karayray1-deactivated20230129

White people get so angry when they’re presented with the truth.

biculturalist-deactivated201612

That moment when a single scene in a Bollywood film educates you about the reality of American politics.

placiddream

BAM

burnoutparadiserayray17

psych-facts

Two things define you. Your patience when you have nothing, and your attitude when you have everything.

Unknown (via psych-facts)

neurosciencestuff

Single protein causes Parkinson’s disease and Multiple System Atrophy

Several neurodegenerative disorders are caused by aggregates of a single protein known as alpha-synuclein. In collaboration with CNRS and the University of Antwerp, KU Leuven neurobiologists have discovered that the shape of these aggregates – ‘cylinders’ or ‘ribbons’ – determines whether a patient develops Parkinson’s disease or Multiple System Atrophy, respectively.

Typical of neurodegenerative disorders is the disrupted communication between brain cells together with a loss of cells in specific brain regions. For some brain diseases this phenomenon is linked to a protein known as alpha-synuclein. The exact function of this protein remains unclear, but it may play a role in the communication between brain cells. However, in the case of specific diseases, including Parkinson’s disease, Multiple System Atrophy (MSA), and dementia with Lewy bodies (DLB), this protein forms aggregates that cause neurodegeneration.

“When alpha-synuclein aggregates accumulate within a brain cell, they interfere with the normal functioning of the cell. The protein aggregates disrupt the communication between brain cells, resulting in cell death. Up to now, nobody understood how aggregates of this single protein could induce different pathologies,” says Professor Veerle Baekelandt from the Research Group for Neurobiology and Gene Therapy.

“You could compare it to the construction of a house,” doctoral researcher Wouter Peelaerts explains. “With the same building blocks – in this case the alpha-synuclein protein – you can create many different structures. In 2013, Professor Ronald Melki and his colleagues from CNRS isolated several forms of fibres called ‘strains’. The two most important strains were cylinder-shaped fibres reminiscent of spaghetti and broad ribbons that resemble linguini. We injected these fibres separately into the brain and blood stream of rats. We noticed that the rats developed different symptoms: while the ‘cylinders’ induced Parkinson’s disease, the ‘ribbons’ caused MSA symptoms.” This clearly demonstrates that distinct diseases result from alpha-synuclein fibres that are structurally different.

“We are gaining more insight into the differences between the diseases,“ Baekelandt concludes. "But we suspect that more fibres with different shapes and effects are waiting to be discovered, apart from the two that we examined in this study. In any case, our findings open up possibilities for the development of new treatments. A drug that counteracts the development of aggregates could be used to treat a whole range of brain diseases.”

quietlotus

Illness, or a trauma, is not a reflection of an inner shortcoming or failure. It is not a cause to find fault, not with our bodies or ourselves. Illness is another experience, illness is a part of life. It is okay to be unwell. Be gently curious about the experience, pour your love into the places where you are hurting, and see what new awareness blossoms. Every experience offers a gift of deeper understanding and inspiration.

Quiet Lotus (via quietlotus)

Quote Lounge

We have eyes, and we’re looking at stuff all the time, all day long. And I just think that whatever our eyes touch should be beautiful, tasteful, appealing, and important.

Eric Carle (via observando)