Portrait of a Woman, said to be of Simonetta Vespucci, tempera on panel (ca. 1480) Piero di Cosimo (Italian, 1462–1522) presents a striking profile often identified as Simonetta Vespucci, the legendary muse of Botticelli. Simonetta features an elaborate, pearl-entwined hairstyle. A small snake curls around her gold necklace, a connection to the death of Cleopatra or an allegory of wisdom.










