DNA Replication & Repair
Remember!!! Inactivation of tumor suppresor genes fuck up DNA repair. Examples:
p53: prevents damaged DNA to enter S phase. Deletion or Inactivation = LiFraumeni Sd.
ATM gene: encodes a kinase for p53 activity. Inactive: Ataxia Telangectasia.
BRCA-1: breast, prostate, ovarian cancer
BRCA-2: breast cancer
Rb gene: negative regulator, binds TF-E2f & repress transcription of genes required in S phase. Inactive or deletion = Retinoblastoma, Osteosarcoma.












