Hustle

[awillzzz]

[awillzzz]

[awillzzz]

[awillzzz]

[joli--coeur]

my rustic room. 🌿🍂🌾 Instagram: kokokourtney

[everythingwithwasabi]

Vegan Lavender Ice Cream 

[mynotes4usmle]

ANTIBIOTICS CHEAT SHEET :)

Also, REMEMBER!!!!

* Sulfonamides compete for albumin with:

Bilirrubin: given in 2°,3°T, high risk or indirect hyperBb and kernicterus in premies

Warfarin: increases toxicity: bleeding

* Beta-lactamase (penicinillase) Suceptible:

Natural Penicillins (G, V, F, K)

Aminopenicillins (Amoxicillin, Ampicillin)

Antipseudomonal Penicillins (Ticarcillin, Piperacillin)

* Beta-lactamase (penicinillase) Resistant:

Oxacillin, Nafcillin, Dicloxacillin

3°G, 4°G Cephalosporins

Carbapenems 

Monobactams

Beta-lactamase inhibitors

* Penicillins enhanced with:

Clavulanic acid & Sulbactam (both are suicide inhibitors, they inhibit beta-lactamase)

Aminoglycosides (against enterococcus and psedomonas)

* Aminoglycosides enhanced with Aztreonam

* Penicillins: renal clearance EXCEPT Oxacillin & Nafcillin (bile)

* Cephalosporines: renal clearance EXCEPT Cefoperazone & Cefrtriaxone (bile)

* Both inhibited by Probenecid during tubular secretion.

* 2°G Cephalosporines: none cross BBB except Cefuroxime

* 3°G Cephalosporines: all cross BBB except Cefoperazone bc is highly highly lipid soluble, so is protein bound in plasma, therefore it doesn’t cross BBB.

* Cephalosporines are "LAME“ bc they  do not cover this organisms 

L  isteria monocytogenes

A  typicals (Mycoplasma, Chlamydia)

M RSA (except Ceftaroline, 5°G)

E  nterococci

* Disulfiram-like effect: Cefotetan & Cefoperazone (mnemonic)

* Cefoperanzone: all the exceptions!!!

All 3°G cephalosporins cross the BBB except Cefoperazone.

All cephalosporins are renal cleared, except Cefoperazone.

Disulfiram-like effect

* Against Pseudomonas:

3°G Cef taz idime (taz taz taz taz)

4°G Cefepime, Cefpirome (not available in the USA)

Antipseudomonal penicillins

Aminoglycosides (synergy with beta-lactams)

Aztreonam (pseudomonal sepsis)

* Covers MRSA: Ceftaroline (rhymes w/ Caroline, Caroline the 5°G Ceph), Vancomycin, Daptomycin, Linezolid, Tigecycline.

* Covers VRSA: Linezolid, Dalfopristin/Quinupristin

* Aminoglycosides: decrease release of ACh in synapse and act as a Neuromuscular blocker, this is why it enhances effects of muscle relaxants.

* DEMECLOCYCLINE: tetracycline that’s not used as an AB, it is used as tx of SIADH to cause Nephrogenic Diabetes Insipidus (inhibits the V2 receptor in collecting ducts)

* Phototoxicity: Q ue S T  ion?

Q uinolones

Sulfonamides

T etracyclines

* p450 inhibitors: Cloramphenicol, Macrolides (except Azithromycin), Sulfonamides

* Macrolides SE: Motilin stimulation, QT prolongation, reversible deafness, eosinophilia, cholestatic hepatitis

* Bactericidal: beta-lactams (penicillins, cephalosporins, monobactams, carbapenems), aminoglycosides, fluorquinolones, metronidazole.

* Baceriostatic: tetracyclins, streptogramins, chloramphenicol, lincosamides, oxazolidonones, macrolides, sulfonamides, DHFR inhibitors.

* Pseudomembranous colitis: Ampicillin, Amoxicillin, Clindamycin, Lincomycin.

* QT prolongation: macrolides, sometimes fluoroquinolones

[ducktracy-deactivated20260315]

my spongebob favorite quotes video is making its rounds again so i made another, there are still so many more it would probably be like an hour long

[gardeninglovers]

zero light plants

[blackwoolncrown]

THIS IS SUCH A SPECIFIC AND SUPER NECESSARY POST.

[lionesshathor]

Spider plants are among the best natural air filters you can put in a flowerpot. They don’t just produce oxygen, they clean out other gases and toxins and whatever else is floating around the room.

Also they’re easy as fuck to grow more of because they reproduce by putting little mini plants out on stalks. Clip one off, stick it in a pot and you’re good!

[braincoins]

Spider plants are safe to have around cats, too!

[nakererurish]

Letters from Kids to God

[jaiwrestledabearonce]

Snaps to God for the stapler.

[sophisticantsophia-deactivated2]

Bruh I can’t

Children are so precious lol 😌😌

[irreleventblue]

I’M LAUGHING SO HARD OH MY GOD

[mikey-xoxo]

ME

[awillzzz]

Anytime Panic! At The Disco comes on

[bloggersfood]

Brown Sugar Lemon Garlic Butter Salmon

[evilspice]

BEYONCES PERFORMANCE IS BEING REBROADCAST RIGHT FUCKING NOW CLICK!!!!!!

[currant]

[mothcub]

[vinstage4u]

[buttwyattarchive-deactivated201]

[theendofaspark]

this is never going to not be funny 

[epitomeofnerd-blog]

Rob Lowe says “that is fucking hilarious” with the straightest face ever

[grapes-of-plath-deactivated2017]

Bless you, Chris Pratt

[drowningz]

This is the hardest I’ve laughed in so long

[edwardspoonhands]

♫♫That’s not something that props can fix…that’s gonna be a little harder to fix.♫♫

[seafoam-aliens]

It’s bACK.

[scumbagsblog]

I’ve seen this a thousand times and I just realized he knocks the fucking Mac of of the counter too