GIOSTAR

  Global Institute of Stem Cell Therapy and Research (GIOSTAR), headquartered in San Diego, California (U.S.A.)  

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World Aids Day

World AIDS Day is held on December 1st each year and is an opportunity for people worldwide to unite in the fight against HIV, show their support for people living with HIV, and to commemorate people who have died. The day was first conceived in August 1987 by James W. Bunn and Thomas Netter, two public information officers for the Global Programme on AIDS at the World Health Organization in Geneva, Switzerland.

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TOP 5 THINGS YOU SHOULD KNOW ABOUT STEM CELLS

 You might have heard about bone marrow transplants, right? Bone marrow transplant or stem cell transplant is used to treat a few types of blood cancer and neurodegenerative disorders. The procedures are often named after the source of stem cells. In this article, we will try and cover a few things about stem cells and their potential. 

Types of Stem cells – 

Usually, 2 types of stem cells are found in our body. One is present during the embryological stage, hence named embryonic stem cells. The other one is adult stem cells. Let’s dive in a little more. 

Embryonic Stem Cells – These cells are derived from embryos grown in vitro. They caught a lot of attention as they are minimally manipulated and still in the growing stage. They are pluripotent, hence they can be modified into more than one category of cells. 

Adult Stem Cells – In an average adult, every organ has certain types of progenitor cells, which gives rise to cells or tissues specific to that organ. They are multipotent cells. Fully developed adult stem cells are found in bone marrow, skin, and any organs. Another type of adult stem cell is induced pluripotent stem cell. These stem cells are isolated and modified in a laboratory to function like embryonic stem cells. Induced Pluripotent Stem Cells were first modified in 2006, but very les research evidence is present as of now. 

Where are stem cells sourced from? 

Stem cells come from three main sources, depending on the type of transplant done.

Bone marrow – Bone marrow is the storehouse of stem cells in our body. It’s main task is to produce and circulate blood cells throughout our body. The extraction of stem cells from the marrow is done to collect sufficient amount of stem cells. After extraction, these cells are stored in deep freezer. When they are needed, stem cells are thawed and injected into the vein of patients just like blood transfusion. 

Bloodstream – Blood doesn’t contain as much stem cells as bone marrow. However, hormone like infusions can make them divide in the blood of donor. After the extraction, stem cells are filtered and stored until the patient is ready. It may take several appointments to get sufficient stem cells. 

Umbilical Cord Blood- After the birth of a baby, the umbilical cord and placenta contains sufficient blood that can be stored and used for transplantation. The stem cells present in cord blood may be less in number, but they can differentiate much faster. 

Types of transplant – 

Types of transplants can be classified under 2 types based on where the stem cells are sourced. 

Autologous transplantation – In this type, patient’s own stem cells are used. Stem cells are isolated from their own bone marrow and treated in vitro, if required. Then, they are transferred into the patient’s body itself, mostly injected. 

Allogenic transplantation – In allogenic, stem cells are collected from a donor. It is note worthy that the patient’s and donor’s tissue type should match, in most cases donor is a close relative of the patient’s, usually brothers or sisters. In some cases in which a good match is not found among immediate family members, stem cells are taken from unrelated donors. Donors donate stem cells through national portals to stem cell bank for times like this. One risk associated with it is the immune cells of the donor may not attack the cancer cells alone, chances are there they may attack healthy cells of the patient as well. 

Stem cell treatments are available for – 

Metabolic disorders. 

Lymphoma. 

Multiple myeloma. 

Anemia and it’s type. 

Leukemia. 

Neuro-degenerative diseases. 

Are you an eligible candidate for stem cell treatment? 

It is hard to decide whether to proceed with the treatment or not because stem cell treatment benefits but not everybody. Stem cell treatments for cancer have proven to be quite effective for many patients all around the globe. On the other hand, many have died due to complications from stem cell treatments. The unanticipated risks makes it more difficult to decide. 

Therefore, it is best decided by an experienced medical team who will weigh the benefits and risks associated with it for you. The type of disease, age and sex of the patients, donor type, cost of treatments are some of the deciding factors. It is your responsibility to express yourself and know what are your expectations and concerns. It is really important to make healthy relations with yourself and your medical team.  To know more about Liver Cirrhosis Treatment and Stem Cell Therapy visit our website : giostar.com

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TOP 5 THINGS YOU SHOULD KNOW ABOUT STEM CELLS

You might have heard about bone marrow transplants, right? Bone marrow transplant or stem cell transplant is used to treat a few types of blood cancer and neurodegenerative disorders. The procedures are often named after the source of stem cells. In this article, we will try and cover a few things about stem cells and their potential. 

Types of Stem cells – 

Usually, 2 types of stem cells are found in our body. One is present during the embryological stage, hence named embryonic stem cells. The other one is adult stem cells. Let’s dive in a little more. 

Embryonic Stem Cells – These cells are derived from embryos grown in vitro. They caught a lot of attention as they are minimally manipulated and still in the growing stage. They are pluripotent, hence they can be modified into more than one category of cells. 

Adult Stem Cells – In an average adult, every organ has certain types of progenitor cells, which gives rise to cells or tissues specific to that organ. They are multipotent cells. Fully developed adult stem cells are found in bone marrow, skin, and any organs. Another type of adult stem cell is induced pluripotent stem cell. These stem cells are isolated and modified in a laboratory to function like embryonic stem cells. Induced Pluripotent Stem Cells were first modified in 2006, but very les research evidence is present as of now. 

Where are stem cells sourced from? 

Stem cells come from three main sources, depending on the type of transplant done.

Bone marrow – Bone marrow is the storehouse of stem cells in our body. It’s main task is to produce and circulate blood cells throughout our body. The extraction of stem cells from the marrow is done to collect sufficient amount of stem cells. After extraction, these cells are stored in deep freezer. When they are needed, stem cells are thawed and injected into the vein of patients just like blood transfusion. 

Bloodstream – Blood doesn’t contain as much stem cells as bone marrow. However, hormone like infusions can make them divide in the blood of donor. After the extraction, stem cells are filtered and stored until the patient is ready. It may take several appointments to get sufficient stem cells. 

Umbilical Cord Blood - After the birth of a baby, the umbilical cord and placenta contains sufficient blood that can be stored and used for transplantation. The stem cells present in cord blood may be less in number, but they can differentiate much faster. 

Types of transplant – 

Types of transplants can be classified under 2 types based on where the stem cells are sourced. 

Autologous transplantation – In this type, patient’s own stem cells are used. Stem cells are isolated from their own bone marrow and treated in vitro, if required. Then, they are transferred into the patient’s body itself, mostly injected. 

Allogenic transplantation – In allogenic, stem cells are collected from a donor. It is note worthy that the patient’s and donor’s tissue type should match, in most cases donor is a close relative of the patient’s, usually brothers or sisters. In some cases in which a good match is not found among immediate family members, stem cells are taken from unrelated donors. Donors donate stem cells through national portals to stem cell bank for times like this. One risk associated with it is the immune cells of the donor may not attack the cancer cells alone, chances are there they may attack healthy cells of the patient as well. 

Stem cell treatments are available for –

Metabolic disorders. 

Lymphoma. 

Multiple myeloma. 

Anemia and it’s type. 

Leukemia. 

Neuro-degenerative diseases. 

Are you an eligible candidate for stem cell treatment? 

It is hard to decide whether to proceed with the treatment or not because stem cell treatment benefits but not everybody. Stem cell treatments for cancer have proven to be quite effective for many patients all around the globe. On the other hand, many have died due to complications from stem cell treatments. The unanticipated risks makes it more difficult to decide. 

Therefore, it is best decided by an experienced medical team who will weigh the benefits and risks associated with it for you. The type of disease, age and sex of the patients, donor type, cost of treatments are some of the deciding factors. It is your responsibility to express yourself and know what are your expectations and concerns. It is really important to make healthy relations with yourself and your medical team. 

To know more about Liver Cirrhosis Treatment and Stem Cell Therapy visit our website : giostar.com

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GIOSTAR Reports on a Positive Outcome of a COVID-19 Patient After Stem Cell Treatment

GIOSTAR Reports on a Positive Outcome of a COVID-19 Patient After Stem Cell Treatment

SAN DIEGO, July 21, 2020 /PRNewswire/ — Global Institute of Stem Cell Therapy and Research (GIOSTAR), the worldwide leader in stem cell research, is pleased to announce the outcome of a COVID-19 patient treated using stem cells. Led by Chairman and Co-Founder Dr. Anand Srivastava, GIOSTAR received approval for the treatment under the U.S. Food and Drug Administration (FDA) “expanded access for compassionate use” program. As of July 14, 2020, there have been more than 13 million COVID-19 cases and over 500,000 deaths worldwide.

Contending with a Grim Prognosis

Under the direction of GIOSTAR Medical Director Dr. Prabhat Soni, a 53-year old male patient suffering from COVID-19 pneumonia was admitted to Saint Michael’s Medical Center in Newark, New Jersey, under the care of Dr. Richard Miller, MD, Chairman, Department of Pulmonary Medicine. The patient’s condition worsened over the course of the standard treatments, along with convalescent plasma therapy. He went into septic shock and his renal and hepatic functions continued to decline, requiring dialysis. The patient suffered a stroke, and remained in a coma at Saint Michael’s intensive care unit (ICU).

Improved Outcomes from an Alternative Strategy

Noting the limited effectiveness of these measures, Dr. Soni designed a plan to treat the patient using stem cells. Research physician Dr. Michael J. DeMarco coordinated the plan, with day-to-day care provided to the patient by Dr. Miller and his Critical Care fellows Dr. Rutwik Patel and Dr. Harish Sharma, at Saint Michael’s.

Following treatment with AlloRx Stem Cells® from Vitro Biopharma, a Colorado-based company, the patient began recovery from multiple organ failure and a coma of almost 7 weeks. He had excellent recovery of his pulmonary, liver, and renal functions, ultimately coming off dialysis and ventilator support.

The patient’s recovery of neuro-muscular functions is evident in improved clarity of speech, ease of swallowing food, and many other everyday functions. Additionally, the elevated levels of inflammation markers seen prior to stem cell therapy have come down to within normal range. The patient was finally discharged from ICU, and is undergoing physical therapy with strong hopes of complete recovery.

COVID-19 and Mesenchymal Stem Cells (MSCs)

COVID-19 infection leads to uncontrolled release of proinflammatory cytokines — known as “cytokine storms” — that potentially leads to fatal damage of many organs of the body. “MSCs have specific characteristics that, when infused in the bloodstream,” explained Dr. Srivastava, “neutralize proinflammatory cytokines (through ‘immunomodulation’), down-regulate the inflammatory gene actions and send messages to regenerate damaged lung and other tissues, which may help in managing COVID-19.”

Next Steps for Treatment of COVID-19

“We got outstanding results after using MSCs on our first patient,” noted Dr. Soni, “with similar results being reported by other institutions.” Dr. Srivastava states that “the use of MSCs may be a great option not only for critically ill COVID-19 patients, but also for those who may have risk of exposure. MSCs may prevent people from aggravations of the infection, thereby potentially saving lives while lowering the load on hospitals and the economy.” Drs. Srivastava and Soni emphasize that a placebo-controlled, double-blind study would be needed to better understand the measurable outcome of stem cell treatment for COVID-19.

About GIOSTAR

GIOSTAR is the pioneer and established leader in the field of stem cell research. Under the leadership of Co-Founders Dr. Anand Srivastava and Mr. Deven Patel, the San Diego-based Institute has a tradition of groundbreaking research in stem cell science spanning over two decades.

Media contact

Deven Patel [email protected]

Related Links

https://www.giostar.com/category/news/ https://www.giostarchicago.com/news

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Prospects of Stem Cell Therapy in Osteoarthritis

Osteoarthritis (OA) is the most common form of arthritis and it affects millions of people on the world. The disease brings about the ultimate destruction of synovial joints. For the patients, quality of life is reduced because of the loss of movement and function and, as the disease progresses, pain from the joint increase to become continuous, even occurring at rest. Underlying the disease is a loss of the normal homeostasis of the joint, generally leading to excessive catabolism relative to anabolism. The arthritic joint can, however, demonstrate apparent repair mechanism, although these often result in overactive but aberrant production of bone and cartilage in the form of osteophytes. 

OA was previously thought of as a wear and tear process. More recently it has been defined, not as a single condition, but rather a common complex disorder with three groups of risk factors: genetic, constitutional (aging and obesity) and local (biomechanical consequence of joint injury, joint laxity or malalignment). OA is not simply a disease of cartilage destruction but a collection of different pathological processes involving several anatomical parts of the joint with the relationship between the underlying bone and the cartilage being recognized in particular.

Different pathways may be involved at different stages of Osteoarthritis. For example, early in the disease, there is an initial increase in inflammatory mediators, matrix- degrading proteinases and stress- response factors in cartilage, perhaps in response to a mechanical injury.

Why is there a need for Stem Cell Therapy to treat OA? To date it is generally believed that there is little to be gained by surgical intervention before the end stage of disease, when arthroplasty can provide excellent pain relief and functional restoration. The problem with joint replacement is that the implants have a finite lifespan after which a variety of factors, such as wear particle formation, contribute to loosening and, therefore, the prosthesis is likely to require revision surgery. This is more complex, costly and not as successful as the initial treatment in the long term. The use of artificial joint in young patients (i.e. <55 years) is associated with higher failure rate as compared to older patients.

As paradigm for tissue regeneration, Stem cells have been used for many orthopedic conditions, including osteoarthritis treatment. The two principle characteristics of stem cells i.e. the ability to self- renew and to differentiate along multiple lineages make them an attractive option to treat age- related disorders that involve more than once tissue, such as degenerative joint diseases and arthritis. Stem cells with their potential influence on modulating the immune system, present themselves as an interesting choice, particularly when those arthritis have an inflammatory component.

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Stem Cells The Next Frontiers in the field of Regenerative Medicine

Diabetes is a type of devastating disorder, currently affecting millions of people around the world. The disease can primarily be categorized into type 1 as well as type 2 diabetes. The former one has primarily associated with the destruction of insulin-producing beta cells. The later form of diabetes, most commonly being identified to be as type 2-diabetes is generally characterized with the acquisition of insulin resistance; a condition is often associated with reduced secretion of insulin, further leading to the progressive decline in the functional attributes of beta cells. Accordingly, researchers are actively looking forward to developing a novel therapeutic solution that can be helpful in reducing the insulin dependency of the patients; if not completely at least the progression can be stopped to the great extent.

However, there has been a very little awareness about how cell replacement therapy is important in producing enough number of beta cells and minimizing insulin resistance; and hence, the current write-up focuses completely on stem cells, which are the novel potential sources of regenerating as well as replacing.

Can diabetes be a critical health issue for the year 2021?

According to the International Diabetes Foundation, diabetes has currently been referred to be as the 7th most devastating diseases, with nearly 250 million people suffering from the same across the globe. With the same speed of progression, the disease prevalence is expected to rise at a speed of 50 million people per year, due to more number of the aging population. The statistical evidence has confirmed that more percentage of people is found to be affected with the help of diabetes, in areas like Asia, South America, etc. The data was confined and further presented through the National Diabetes Fact sheet; which particularly expressed almost around 54 million cells to be pre-diabetic in nature. This silent killer has been reported to be significantly affecting the lives of many people due to progressive destruction of other vital organs of the body, like kidneys, heart, and eyes. In this regard, a novel treatment that has recently started reaching the horizon is identified to be stem cell therapy for diabetes, which is primarily involved in regenerating new beta cells to replace those that are functionally impotent.

What are the less common treatments available for diabetes?

With the increasing trends and advancements in the technology, the world is getting attracted towards some of the newer treatment approaches that are not really very common, like Bariatric surgery, artificial pancreas, transplantation of pancreatic islets cells, etc. However, one such treatment is getting more and more acknowledgment in terms of faster recovery, cost-effectiveness and better treatment outcome in the context of safety as well as feasibility; and that is known as stem cells therapy for diabetes.

Stem cells are identified to be as the naive cells of the body, with the ability to be differentiated into different cells of multiple tissue origin. These cells can either be isolated from patient’s own body or can be extracted from one of the richest sources, the umbilical cord tissue to be infused directly into the pancreas and allowed to differentiate directly into pancreatic beta cells. These stem cells being anti-inflammatory in nature can regulate the inflammatory responses and prevent further destruction of the body’s own cells.

Thus, a person with diabetes mellitus can be reversed with the help of stem cell therapy; however, should be chosen as the first choice of treatment is safe as well as feasible in nature. As a matter of fact, it should also be understood that along with stem cell therapy, some rehabilitative strategies should necessarily be implemented like good diet, regular exercise and regular medical checkups.  

 To know more about Stem Cell Therapy for Diabetes and  Stem Cell Therapy  visit our website : giostar.com

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Know About Osteoarthritis

Osteoarthritis routinely abbreviated as OA, is a common joint disorder mostly affecting middle age or elderly people. Classically, the condition was thought to be due to overuse or high pressured joints, but it has recently to be understood as the abnormality, associated with the entire joints, involving different parts such as cartilages, joint lining, ligaments and bones. The condition primarily symbolizes the breakdown of the cartilages; the tissue that is padded between the two bones for the ease of movement and lubrication. It as well specifies the deterioration of tendons, ligaments and various degree of inflammation of the joint-lining also called as synovium.

The OA is mainly prevalent for knee joints although it can be widespread to any joints of the body such as joints of hands, spine, hips and toes. However, life time risk of development of osteoarthritis is about 46% for knees, due to their weight bearing nature.

Knowing your condition about Osteoarthritis

As a general thumb rule, initiation of osteoarthritis is a very slow, asymptomatic process that can be advanced at a faster rate. In the early phase of its progression, occasional pain can be experienced after certain type of vigorous motion or exercises, which can be constantly reported in the later stages of its development; along with the joint stiffness. Different characteristics of the condition can be based on the affected joints as follows.

·        Elbows & Fingers: - OA of hands has been observed to be genetic in nature and runs in the families. If the person is genetically predisposed to it, he is at the greater risk of developing Osteoarthritis. Women after menopause are more likely to be affected with the condition. In case of hands, small bony spurs can be visible at the end of the joints and on the middle joints of the fingers. Fingers can be enlarged and gnarled with the aching, stiffness and numbness.

·       Knees: - Knees are among the most commonly susceptible joints due to their weight bearing capacity. The reported symptoms associated with the condition can be stiffness, swelling and pain; which make them hard to function such as walking, standing, running, etc. The disability can affect the normal quality of life to a great extent.

·      Hips: - This is less common as compared to knee arthritis. As in case of other joints, symptoms of hip joints are pain, stiffness, etc. although the pain can be felt by groin, inner thighs or buttocks. This type of OA, generally limits moving as well as bending.

·     Spine: - OA of the spine can be confirmed with the pain and stiffness in the neck and lower back region. Some of the patients can as well complain about weakness, tingling sensation of hands as well as arms and/or numbness of the legs due to arthritis induced pressure on the central nervous system. In the severe stages, this can lead to bladder as well as bowel problems.

On a general note, the commonly emphasized treatment of Osteoarthritis goals are to manage pain, improve joint function, stop or slow down the progression of the condition and lastly to achieve a healthy life style. These goals can be fulfilled in a very short time period without any invasive procedures or surgery with the help of mesenchymal stem cells activated by patient’s own platelet rich plasma.

According to the supporting literature, these stem cells therapy can be differentiated into cells of cartilaginous, bone and brain origin; restoring the lost function of mobility and support. The stem cells can also reduce the inflammation associated with the condition to manage the pain, thus making it feasible alternative.

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Diabetes Mellitus The Success Pathway Of Stem Cell Therapy

Currently, healthcare system is facing variety of challenges globally; finding an effective diabetes treatment is one of them. Diabetes is the Simplest version of the metabolic diseases with very remote risk factors; which are yet to be pinpointed. The symptoms of this mysterious disease can be controlled but cannot be cured completely. However, the promises made by science of regenerative medicines and stem cells, have given a new hope to the medical fraternity.          

Stem cells are the unique precursor cells of the body, with the great potential to differentiate into variety of cells, on demand. This property of stem cells can as well be applied to the diseases like diabetes, wherein human body is in crisis of insulin producing beta cells; more commonly known as the pancreatic cells. This facet of regenerative medicine has sparked great interest in many scientists in order to achieve a hallmark therapy for diabetes with the help of stem cells.

What is Diabetes?

Diabetes is a common form of autoimmune, metabolic disorders. The human body requires energy, to perform various complicated functions such as breathing, digestion, etc. The energy is acquired through carbohydrates or more precisely though glucose molecules. These glucose molecules are being released into the blood from food via certain digestive juices. In order to transport this glucose into the cells; a vehicle is required, which is known to be the insulin. This insulin is produced by the beta cells of pancreas.In type 2 diabetes, the insulin is either not produced by the pancreatic beta cells or it cannot utilize the glucose molecules; whereas in case of type 1 diabetes, pancreatic beta cells are damaged due to autoimmunity.

Conventional Treatments

Currently, there is as such no cure available for diabetes. However, type 2 diabetes can atleast be managed with the consumption of some of the medicines, healthy diet and regular exercise; on the contrary, type 1 diabetes cannot be controlled unless and until some hormonal supplements are being taken. If left untreated for the longer period of time, high blood sugar can cause serious damage to heart, eyes, kidneys, etc. Thus, an alternative, ambitious treatment, such as stem cell therapy can be opted to manage the disease symptoms and to reduce the hormonal dependency.

With the recent advancements of technology and science, it is now possible to isolate stem cells from various potential sources; both autologous as well as allogenic. In case of autologous sources, bone marrow and adipose tissues are known to be the best available choices, for obtaining hematopoietic and mesenchymal stem cells. Similarly, allogenic mesenchymal stem cells can as well be availed; if in case, the higher number is suggested for infusion. These cells are processed under controlled conditions, to get enriched in viability and concentration and then can be infused back into the body. The most trusted route, in case of diabetes patients is local infusion; directly into the pancreas. Once inside the body, these cells are known to proliferate and differentiate into desired pancreatic beta cells to restore the lost function back.

Various clinical data, is suggesting that with the application of stem cell treatment and with the implementation of ideal route of administration, the symptoms of diabetes can be managed with reduced insulin dependency.

To know more about Stem Cell Therapy for Diabetes and  Stem Cell Therapy  visit our website : giostar.com

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INDIAWEST NEWS – Indian American-founded GIOSTAR Announces FDA Approval for COVID-19 Clinical Trial with Stem Cells

San Diego, California-based Global Institute of Stem Cell Therapy and Research, a leader in stem cell research, has announced that they have received an approval for a COVID-19 clinical trial, led by their Indian American medical director Dr. Prabhat Soni. GIOSTAR will conduct the trial using stem cells to treat COVID-19 patients under the approval of the United States Food and Drug Administration “expanded access for compassionate use” program, said a PRNewswire report. The institute is exploring a promising alternative approach to the devastating disorder, which leverages the anti-inflammatory properties of mesenchymal stem cells (MSCs). According to Soni, the investigation is based upon two decades of stem cell research by GIOSTAR’s Indian American co-founder, chairman and chief scientific officer Dr. Anand Srivastava.

The COVID-19 pandemic has resulted in unprecedented disruption, with more than 3 million cases and 200,000 deaths reported worldwide as of May 1, 2020, a figure that is projected to grow exponentially in the weeks ahead, noted the report. Physicians have resorted to numerous traditional and unconventional therapies to combat the effects of COVID-19. These therapies, which include antibiotics and plasma therapy, have, however, proven largely ineffective in managing the spread of the pandemic.

Given these challenges, there has unsurprisingly been a surge in clinical trials for use of MSCs to combat COVID-19. Cedars-Sinai Medical Center recently cited studies that “support the notion that cell therapy can attenuate inflammation, which may be attractive in COVID-19.” One study by an international coalition of researchers from China, United States, India, France, and other countries appeared in Aging and Disease, showing full recovery of seven COVID-19 patients 2 weeks after receiving intravenous administration of allogeneic (sourced externally from donors) MSCs.

COVID-19 is induced by a release of signaling molecules known as cytokines, small protein molecules released by immune cells to orchestrate the “attack-and-destroy” mode of the host’s immune system response to pathogens, explained the report. Cytokines are either proinflammatory (“bad”) or anti-inflammatory (“good”), meaning that they either increase or decrease levels of inflammation in the body. In the case of COVID-19, an uncontrolled immune response leads to a “cytokine storm,” dramatically raising levels of IL-6, IL-8, and TNF-alpha and other proinflammatory proteins. The immune system then goes into “overdrive” mode, thereby causing potentially fatal damage to the patient’s own tissues and organs.

Srivastava and Soni sought to leverage and apply extensive research demonstrating the effectiveness of MSCs in combating the respiratory symptoms and cytokine storms associated with COVID-19. “The cells have specific characteristics that, when infused in the bloodstream,” Srivastava explained in an educational video, “neutralize the proinflammatory cytokines, down-regulate the inflammatory gene actions (through ‘immunomodulation’), and send messages to regenerate damaged lung tissues.”

Seeing great potential in this therapeutic approach, the FDA approved MSC-based treatment for use in the most severe cases of COVID-19, under their “expanded access for compassionate use” program. The first patients will be treated in New York City. The city has been among the most severely impacted regions of the country, with more than 170,000 confirmed cases of COVID-19 and 13,000 deaths as of May 1, 2020.

“GIOSTAR appreciates the FDA for their timely action in approving the protocol,” noted Soni. “We’re looking forward to sharing the findings from our studies with the world, which may help save many lives in the future.”

GIOSTAR is a leader in the field of stem cell research. Under the leadership of co-founders Srivastava and Deven Patel, the San Diego-based institute has a tradition of groundbreaking research in stem cell science spanning more than two decades, said the report.

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Arthritis: What you need to know more about?

Lifestyle changes have welcomed various health concerns like overweight, reduced bone density, infertility, etc.; which are indeed responsible for variety of underlying dangerous conditions such as arthritis. It has been estimated that around 50% people, over the age 65 can have arthritis. Hence, indeveloped countries, arthritis can be one of the leading health issues, which need to be tackled well within time to avoid increased social economic burden.

Arthritis can be categorized as an inflammatory, joint disorder; affecting multiple joints at a time. The condition has more than 100 subdivisions, with osteoarthritis and rheumatoid arthritis as the most common forms. It is simply known to be a slowly progressive disease, affecting persons of any age groups; although women are known to be more prevalent than men.

Our joints are made up of joining of two bones to allow easy movement. These joints are being protected with the underlying tissue named, cartilages. The cartilages are soft, spongy tissues; acting as beds in between the two bones. Due to the presences of these tissues, the friction between the two bones is reduced, while joints are in mobile state. The cartilages are as well supported with the presence of synovial fluid, which is helpful in shock absorption. Thus, the entire assembly can access an easy and long term functionality of joints. However, variety of issues such as obesity, smoking, poor diet, etc. can create non significant inflammatory responses, which can degenerate these supportive tissues such as cartilages and synovial fluid; exposing bones to outer shocks and friction, leading to their damage.

Stem cells are the young, privileged cells with the capacity to differentiate into cells of different origin. The property of stem cells can be uniquely identified to be potential treatment for arthritis patients. Autologous stem cells isolated from two different sources such as adipose tissue and/or bone marrow can provide mesenchymal and hematopoietic stem cells in abundance. These stem cells are enriched in the laboratory and infused back in the patient’s joints to avail maximum benefits of tissue function restoration. Once inside the body, these stem cells are known to reach at the site of injury, due to their strong communication pathways with other cells, secrete growth factors to reduce the inflammation and elicit strong immunological reactions to speed up the process of healing. Stem cells, in case of joints problems or arthritis are known to induce cells of Chondrocytes origin and get differentiated into cartilages. Once differentiated into cartilages, there can be reduced friction and pain associated with OA.

Thus, considering their anti-inflammatory and regenerative capacities; there are pretty good reasons to say that these stem cells can be good candidates for treatment.

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THE FUTURE OF REGENERATIVE MEDICINE

Stem cells therapy is a futuristic treatment option; getting predominant due to its ability to cure variety of deadly, debilitating disorders, with the theory of regeneration.Medical fraternity is more keen to understand the potential of these mighty cells and the hurdles that need to be taken over, before implementing these options as a routine treatment.

In reality, there is no seen or unseen limit to cure different types of diseases.These stem cells have thecapacity to make breakthroughs in any disease; if the route of administration is fine tuned. Many clinical studies are on the way and have been channelized to assess maximum recovery and many of them have already been approved.

An autologous application of stem cells, isolated from bone marrow has been the most trusted and widely accepted treatment modality. These were the first stem cells that were isolated from the human body and processed in the laboratory to be utilized for many cancer patients. Since then, it has become a gold standard treatment for variety of leukaemia patients, worldwide.

It is quite a true that only few stem cells therapies have been approved with the FDA; however there is a long way to widespread utilization of these novel treatments, due to many steps that must be through, in order to prove their safety and efficacy.  However, scientists if gave up on therapies; simply because of the hardship they are facing for approval; there would not have any of the life saving technologies that are now used routinely.

Moreover, an accumulated data from various clinical studies have not shown any negative effects so far. Thus, although stem cells treatment has to still drive a long way; it is definitely a better options for debilitating disorders, for which currently no option available.

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HOW IS STEM CELL THERAPY USEFUL FOR PARAPLEGICS?

With lot of evidences obtained from various clinical studies, it has now been quite obvious that there is a possibility of paraplegic individuals, with complete paralysis of lower part of the body of walking again. It was not a very long time that some individuals with complete and/or partly paralyzed body were being treated as good as vegetables, being confined to the bed without any possible conventional treatment option. However, with the help of stem cell therapy, it is possible to effectively bring them back to the life.

Stem cells are the preliminary cells of our body with the ability to produce multiple cells of different tissues. In a diseased condition, like paralysis neuronal cells are damaged or weakened forcing them to be dormant without any functional contribution. Since, these neurons are not able to conduct any messaging information to their associates, a patient experience a complete or partial vegetative state of the body. Stem cells, when extracted from other unused parts of the body, such as bone marrow, adipose tissue, etc.; can be enriched outside the laboratory and infused back at the site of injury to allow their targeted differentiation.

Global Institute of Stem Cell Therapy and Research can be noted as the premium institute, facilitating stem cell research and its therapeutic applications, headquartered in San Diego, California (USA); and is progressing at a faster pace with the vision to provide effective solution to various degenerative diseases. We have mastered our technology in isolating stem cells from autologous tissue sources, enriching them in the laboratory and infusion back at the site of injury.

The meaningful research on various facets of regenerative medicines that has been carried out at GIOSTAR has indeed been documented in various prestigious journals.

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Tips to Control Diabetes during Pregnancy

It is a very joyful feeling for women who are going to be a mother. And there is no question in that every mother wants a healthy pregnancy and wish to deliver a healthy baby always. It can only be obtained from a healthy lifestyle after conceiving a baby.  

For those women, who are suffering from diabetes, they should be more conscious of their health. And this is because as their pregnancy progresses, due to diabetes are at high risk for high blood pressure, preeclampsia, eclampsia, preterm and prolonged labor, caesarean section and its associated complications. 

Here are the key tips you must follow when you have diabetes during pregnancy:-  

§  Make A Visit To The Doctor If You Are Planning To Conceive  

It is very much important to talk to your doctor to make sure that your general health is fine. Your doctor will ask to get done some tests like sugar test, blood pressure, kidney function, a thyroid test, and an eye test because it can get worse during pregnancy. 

§  Exercise Daily

In line with diabetes treatment specialists, exercise will help you metabolize food better. It can keep control of blood glucose and weight during and after pregnancy. Mostly the doctor recommends 45 minutes walk and doing yoga in pregnancy. 

§  Control Carbs Intake 

Plan a proper diet – what to eat and what not to eat. Think of how much carbohydrate you should take in the meal. Try to limit the amount of carbs you eat because it will raise your blood sugar that can create problems in the future and affect the baby too. 

§  Eat More Veggies

Eating green is always a healthy choice for mother and baby both. Vegetables are filled with phytonutrients and provide you fibers, plus they aid digestion and put off excess weight gain. They also have low calorie and are low in carbohydrates, so they won’t have an effect on your blood sugar. Here, lettuce, carrots, cucumber, and broccoli are all good choices in vegetables. 

§  Morning Sickness Remedies

Make sure you eat every 2 to 3 hours during the day to keep out nauseousness. A small source of fast-acting carbohydrates such as glucose tablets, honey or fruit juice can help if your blood glucose level is low. Add some Greek yogurt and eggs for protein sources.

§  Bon Appetite

In the first trimester - try to eat fresh vegetables and fruits for good sources of calcium. This can control your appetite and prevent sugar cravings. Avoid fruit juice which is already high in sugar, instead you can eat fresh fruits. 

§  Drinks Consumption

Keep yourself hydrated; drink plenty of water during pregnancy. Be sure to avoid juice, soda, sports drink and sweeteners in coffee and tea. Avoid these or substitute them with something that has less in calories and less in carbohydrates because that’s going to be the source of raising blood sugar.  

§  Enjoy the Desserts

It’s ok to enjoy the piece of cake or chocolate chips, and cookies but balance the total amount of carbohydrates. If you want dessert, make yourself full of salad first instead of a large piece of cake, which also works as a sweet controller system. 

§  Care after Pregnancy

It’s important to consult the doctor, make regular check-ups and control over blood glucose. It’s always difficult to get back into shape after pregnancy; it only happens when you change the lifestyle and eating habits. Don’t worry everything is possible!

According to Dr Anand Srivastava, always keep in mind your good health is essential for you and your baby. So make a healthy lifestyle and seek out for information whenever it is needed. Enjoy your pregnancy period and bless with a healthy baby. 

 To know more about Stem Cell Therapy for Diabetes and  Stem Cell Therapy in India visit our website : giostar.com

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What Are Different Treatment Options for Arthritis

Arthritis refers to the condition of pain, swelling or stiffness in a joint or joints of a person. Million of peoples across the world suffer from arthritis and it is affecting every e generation dash children, adults, teenagers and elderly, likewise.

The necessity for early treatment

Arthritis treatment begins with tracing reason/s causing the pain. Only right and timely treatment can offer relief. The key to the treatment lies in staying physically active and mobile.

Rheumatologist believes that early arthritis treatment is a window of opportunity to stop rheumatoid arthritis in its track.

Various arthritis treatment options can be opted for remission, depending upon the condition of the patient:-

1) Medications

Different kinds of arthritis medications are available. Some are over-the-counter( OTC) painkillers which can be bought easily from medical stores. But this can cause harm if not taken under the direction of a medical practitioner.

It is very important to keep the proper track of the medications taken, its doses and under what conditions these were prescribed. A rheumatologist treats arthritis and its related conditions prescribing various medicinal drugs.

While treating arthritis with medications, it is important to practice precautions like storing meds carefully, combining meds and not skipping the meals, etc.

2) Natural arthritis treatment

Using and consuming some natural supplements and herbs can prove helpful in arthritis treatment to a large extent. Many natural ingredients are being tested in well-designed clinical trials. They have shown properties effective in treating rheumatoid arthritis, osteoarthritis, and other arthritis-related conditions. 

Products like fish oil, flaxseed, ginger, turmeric, Thunder God Vine, Sam-e, Rosehips powder, Pine bark, Indian Frankincense. Glucosamine, ginkgo, Bromelain (enzyme found in pineapple), black currant oil, Avocado soybean unsaponifiables, and many other natural ingredients can help fight arthritis issues. But they should be consumed in the quantity recommended by doctor.  

“Try avoiding nightshade vegetables, such as tomatoes, paprika, white potatoes, eggplant, bell peppers, cayenne pepper. These vegetables have chemical content called solanine that is known to enhance arthritis”, says Dr Anand Shrivastava, a professional having good knowledge of Arthritis and its treatment.

3) Joint surgery

Surgery of the joints is the solution where arthritis pain persists even after healthy body weight and regular exercises. Formal discussion with the doctor and his/her prescription is a pre-requisite to ascertain the necessity of surgery. There are certain pros and cons associated with the joint surgery option as although this offers immediate relief from arthritis and improves the ranges of motion, many people are not able to recover as expected in post joint surgery conditions.

Simple and cost-effective arthritis treatment options

Ø  One of the simple and inexpensive treatments for arthritis is the usage of heating pads and cold treatments for pain relief.

Ø  There is electrical nerve stimulation or neuromodulation methodology.

Ø  Aromatherapy is also used for pain relief.

Ø  Some people opt for a massage at a spa or a treatment room to relieve soring joints and muscles.

Ø  Indulge in joint-friendly physical activities to the extent the body allows without fatigue. Practice regularly at least one of the below listed:-

·       walking

·       swimming

·       cycling

   To know more about Arthritis  Treatment   and  Stem Cell Therapy in India 

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Namaste Trump - GIOSTAR CEO Visit To India

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Is stem cell therapy for face effective?

Almost every living being has to go through a process of ageing, and human being are also not an exception. Today, good appearance has become more than a necessity; as it makes one’s overall personality very impressive and positive. Ageing population of developed countries, is spending millions of dollars to look young and attractive. However, nothing works out at some point of time and you tend to accept your ageing, at the same.

Ageing is actually associated with lot of physical and emotional changes in your body. The skin and muscles become loose due to lack of elasticity, Wrinkles cannot be avoided to some extent, but their appearance can be delayed with the help of latest technological development. Stem cell therapy has been recently identified to be the modern, yet alternative approach to delay the process of ageing, naturally yet effectively.

Stem cells are the youngest cells of our body, with the ability to differentiate into cells of different tissue specific origin. The utilization of stem cells, reserved in different organs of the body, to delay the process of ageing; through natural production of lost cells has been acknowledged to be possible and effective through the latest medical science.

Global Institute of Stem Cell Therapy and Research can be noted as the premium institute, facilitating stem cell research and its therapeutic applications, headquartered in San Diego, California (USA); and is progressing at a faster pace with the vision to provide effective solution to various degenerative diseases. We have mastered our technology in isolating stem cells from autologous tissue sources, enriching them in the laboratory and infusion back at the site of injury.

The meaningful research on various facets of regenerative medicines that has been carried out at GIOSTAR has indeed been documented in various prestigious journals. It is to be noted that GIOSTAR treatment protocols, are well standardized and are completely safe and authenticated.

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Can Stem Cell Therapy Cure Kidney Failure?

Kidneys being one of the vital organ of our metabolic system, we cannot afford to make them nonfunctional, due chronic kidney disorders. As we all know, in some of the developed countries, on the go life style has forced many people to be suffering with life threatening disorders, such as heart attack, high blood pressure and chronic diabetes can have major impact on normal functioning of our kidneys. In this regard, although demand for kidney transplant is increasing across the globe, there is still a scarcity of suitable donated organs to fulfill this growing demand.

In such scenario, stem cell therapy can be helpful in offering alternative therapeutic solution to people with kidney disorders. In the studies related to further analysis of number of cells involved in kidney functioning, it has been evident that a type of cell identified to be renal progenitor cells is responsible for structuration of nephrons, that are primary responsible for proper kidney functioning.

Stem cells are characterized with their ability to differentiate into multiple tissue specific cells, including renal progenitor cells of nephrons. Further research in the area has suggested that some of the resident stem cells found near the area of nephrons are similar in characteristic as that of bone marrow stem cells. In the case of diseased condition, the number of stem cells is not sufficient to make up the number of lost or degenerated cells. Thus, isolation of stem cells from autologous sources such as, bone marrow and adipose tissues can be effective in restoring function of lost nephrons, leading towards the effective cure.

Global Institute of Stem Cell Therapy and Research can be noted as the premium institute, facilitating stem cell research and its therapeutic applications, headquartered in San Diego, California (USA); and is progressing at a faster pace with the vision to provide effective solution to various degenerative diseases. We have mastered our technology in isolating stem cells from autologous tissue sources, enriching them in the laboratory and infusion back at the site of injury.

The meaningful research on various facets of regenerative medicines that has been carried out at GIOSTAR has indeed been documented in various prestigious journals.