*Scroll to the bottom portion of this post to view my test results...
PSA: If you are struggling with a mystery illness and cannot find the "right" medical specialists, I do formally recommend making a request to your most trusted physician about a blood serum/plasma panel known as "VECTRA." Testing individual inflammatory markers like C-Reactive Protein (CRP) and Erythrocyte Sedimentation Rate (ESR) will inform you about potential inflammation underway in your body, but VECTRA is far more comprehensive & can give you insight into your disease activity as compared to a large population of patients with diagnosed rheumatoid arthritis.
[Sort of Unnecessary Side Quest: HAVING A NEGATIVE ANA RESULT IS NOT A REASON FOR A PHYSICIAN'S DISMISSAL! Personally, I have consistently tested negative on ANA panels, and after 20 years of this horseshit, that god awful test is the sole reason for being dismissed by many, many specialists time and time and time and time and time again... A negative ANA alongside positive inflammatory markers (like CRP & ESR) is termed "seronegative." Seronegative autoimmune diseases, although far less common, are absolutely real and deserve the same attention from physicians as the more common, seropositive autoimmune diseases. VECTRA can help prove your pain is valid and needs treatment, especially in the face of a consistently negative ANA!]
VECTRA Panel Pros/Cons (& What It Can Do For You)
What it definitely means/can do to help expedite the diagnostic process:
Measures RA disease activity: VECTRA provides an objective score reflecting the level of inflammation and joint damage that is suspected to occur without appropriate and prompt treatment.
Monitors treatment response: Helps doctors determine whether a patient's RA treatment is working or if adjustments are needed.
Assesses risk of joint damage: Higher scores are associated with increased risk of progressive joint damage.
Incorporates multiple biomarkers: The test evaluates 12 proteins associated with inflammation and immune activation, offering a more comprehensive look at disease activity compared to single-marker tests (e.g., CRP alone).
What it could mean but is not definitive without further testing:
Could indicate active inflammation: A high VECTRA score suggests ongoing inflammation, but it does not pinpoint the exact cause. Additional testing is needed to determine if another condition (e.g., chronic infection, another autoimmune disease with similar features, certain types of cancer, etc.) is contributing.
Could correlate with other inflammatory conditions: While designed for RA, some biomarkers in the test can be elevated due to other inflammatory or autoimmune diseases.
Does not confirm or rule out RA: A high or low VECTRA score alone does not diagnose or exclude rheumatoid arthritisāother clinical criteria and tests (ANA, RF, Anti-CCP, Tissue Imaging, Gene Mutation Analysis, etc.) are required for a diagnosis.
What it does not mean/can't tell you/can't do for you:
Not Covered by All Insurances: VECTRA is a Labcorp-owned blood panel. Unfortunately, this privatization of services does mean that VECTRA may not be covered by certain health insurance plans. Be sure to check with your insurance company first before moving forward with testing.
Does not diagnose RA: VECTRA is a disease activity test, not a diagnostic test for rheumatoid arthritis specifically.
Does not differentiate between different autoimmune diseases: Elevated markers may suggest inflammation, but they do not confirm RA specifically. The test simply compares your disease activity with approximately 300,000 patients definitively diagnosed with RA and can help define the severity of the disease activity in your body.
Not useful for all RA patients: Some people, particularly those with low CRP levels or seronegative RA, may not get reliable results from this test.
Not a replacement for imaging or clinical assessment: While VECTRA provides valuable biomarker data, physical exams, imaging (X-rays, MRIs), and other lab tests remain essential for evaluating RA progression.
My VECTRA Blood Panel Results
What My Results Definitely Mean For Me:
My Vectra DA Score is 45, which falls into the high disease activity category.
A high Vectra score indicates that I have some sort of disease underway that is highly active & that correlates with an increased risk of radiographic progression (observable joint damage/erosion). In other words, I am dealing with a chronic, observable disease which is causing severe & ongoing damage to my body - resulting in multi-system organ involvement and an array of primary diagnoses that may rather be secondary comorbidities of my unnamed systemic illness instead. AKA it means I'm sick AF you guys. Literally all the time. For 20 fucking years straight.
My 1-year risk of radiographic progression is 7%, suggesting a predictable joint damage progression within the coming year if left untreated or mismanaged.
My highest inflammatory marker percentile result listed was EGF (Epidermal Growth Factor), which showed that, compared to the tested RA patients, I am in the >99th percentile for this inflammatory marker. This essentially means that, if continued to be left unmanaged, the progression of this disease could result in irreparable joint and tissue damage. [These higher percentile scores typically display which disease pathway that needs to be targeted in order to treat the condition.] (Example: Biologics that treat diseases like Crohn's often target Interleukin 6, an inflammatory cytokine that, for me, has always tested within the normal range. Long story short, this VECTRA panel helps pinpoint possibilities for treatment potentially [despite maybe never being able to give this a formal name], but due to the complexity of my case, we still have a long way to go and lots more tests to undergo before this gal could potentially see any sort of remission.)
"A Guide to Your VECTRA Molecular Result" as Published by Labcorp for Patients
"Guiding Rheumatoid Arthritis Treatment Decisions" (with regard to VECTRA results) as published by Labcorp for Patients
"Rheumatoid Arthritis Comprehensive Testing Capabilities" as Published by Labcorp for Patients
