jlar.editor

Journal of Lab Animal Research Jlar publishes the results of original papers, case reports, and reviews on all aspects of the care and use of animals in research. jlar.rovedar.com

[jlareditor1]

Preoperative imaging is a key tool in small-animal surgery; however, its predictive value for postoperative complications remains to be carefully investigated. The present study aimed to assess the predictive value and limitations of preoperative radiology for postoperative complications in small animals, based on evidence from in vivo studies.

Available at:https://doi.org/10.58803/jlar.v5i3.107

[jlareditor1]

Animal models have been the primary factor in preclinical cancer studies for decades. Despite advances in molecular biology and cell culture, translating animal findings into human trials remains challenging. The present study aimed to comprehensively assess the role of animal models in cancer studies, their contribution to the discovery of new therapies, and their success in predicting human responses.

Available:https://doi.org/10.58803/jlar.v5i3.110

[jlareditor1]

Probiotics represent the most extensively investigated strategy for maintaining broiler performance under antibiotic-free conditions. The present study aimed to quantify the effects of dietary probiotic supplementation on body weight gain, average daily gain (ADG), feed conversion ratio (FCR), feed intake, intestinal morphology, gut microbiota composition, and short-chain fatty acid (SCFA) production in broiler chickens.

Available at:https://doi.org/10.58803/jwps.v5i2.128

#translation #applied #linguistics #research #animal_lab

[jlareditor1]

Artificial intelligence (AI) is gradually transforming surgical approaches in human and veterinary medicine, but its application in soft tissue surgery is still in its early stages. The present study aimed to comprehensively examine the roles of AI in soft-tissue surgery and to outline the prospects for using AI in veterinary medicine based on in vivo studies.

Available at:https://doi.org/10.58803/jlar.v5i2.106

[jlareditor1]

Exercise training with antioxidant and anti-inflammatory supplements plays an effective role in dementia progression, and tryptophan is an essential amino acid that can be supplied through the diet. The present study aimed to investigate the effects of treadmill exercise and tryptophan supplementation on brain antioxidant levels, synapsin 1 (SYN1), brain-derived neurotrophic factor (BDNF), and postsynaptic density-95 (PSD-95) mRNA in rats fed a high‑fat diet (HFD).

Available at:https://doi.org/10.58803/jlar.v5i2.105

#translation #applied #linguistics #research #animal_lab

https://www.instagram.com/p/DZZZ1tlstsN/?igsh=MXA3aXNieXZ5NGViYg==

[jlareditor1]

Limited space often presents a significant challenge in laboratory animal housing systems, as it restricts the animals' capacity to exhibit species-specific behaviors due to enclosures and structural designs that differ from their natural habitats. The present study aimed to develop a complex caging system (semi-natural cages) equipped with different enrichment items to assess the welfare of rats housed in these cages by observing home-cage behaviors, measuring fecal glucocorticoid metabolites, body weight, and certain organ weights.

Available at:https://doi.org/10.58803/jlar.v5i2.92

#translation #applied #linguistics #research #animal_lab

https://www.instagram.com/p/DZF4Yy_Makb/?igsh=emVtb3NzbWZoc3Bj

[jlareditor1]

Embryo transfer in murine models is a fundamental technique in biomedical studies, particularly in reproductive biology, genetic modification, and transgenic animal production. Successful implementation of this method requires appropriate laboratory infrastructure, technical expertise, and careful standardization of procedures. The present study aimed to report the first pilot embryo transfer in mice at the National University of La Plata, Argentina, and to evaluate the technique's initial feasibility and efficiency.

Available at:https://doi.org/10.58803/jlar.v5i1.97

https://www.instagram.com/p/DYsOAB_MyD4/?igsh=MWp5NmNyOTJpNm5obg==

[jlareditor1]

Captive tree shrews (Tupaia belangeri) are widely used as experimental models for neurological, visual, and infectious disease studies. Despite evidence suggesting a genetic or physiological predisposition to systemic amyloidosis in this species, its clinicopathological characteristics are still poorly understood. The present study aimed to characterize clinicopathological changes associated with systemic amyloidosis in a captive breeding colony of Tupaia belangeri (T. belangeri) and to explore potential early ante-mortem indicators in blood indices, imaging, or clinical examination of the disease.

Available at:https://doi.org/10.58803/jlar.v5i1.88

#translation #applied #linguistics #research #animal_lab

https://www.instagram.com/p/DUz2CMgjn_j/?igsh=dHpldWZnNXNmNnY2

[jlareditor1]

The emergence of clustered regularly interspaced short palindromic repeats (CRISPR)/Cas genome-editing technology represents fundamental changes with significant implications for oral and maxillofacial medicine. The present study aimed to synthesize current evidence from fundamental in vitro studies, engineered animal models, and emerging clinical trials to critically evaluate the potential applications and challenges of this biotechnology.

Available at:https://doi.org/10.58803/jlar.v4i6.91

#translation #applied #linguistics #research #animal_lab

https://www.instagram.com/p/DUcskwrjC_2/?igsh=MTd6NWZ1MmRzdmd0ZA==

[jlareditor1]

Spaying female rabbits may be necessary to control certain behaviors and prevent pregnancy. Since gaseous anesthesia is unavailable under field conditions, injectable anesthesia is required. The present study aimed to evaluate the efficacy of routine injectable intramuscular anesthetics, including ketamine and xylazine, during the spaying procedure in rabbits.

Available at:https://doi.org/10.58803/jlar.v4i6.85

#translation #applied #linguistics #research #animal_lab

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[jlareditor1]

Wishing everyone a Happy New Year as we welcome a new beginning and a promising year ahead.

[jlareditor1]

Roles of Artificial Intelligence in Enhancing Diagnostic Pathology and Surgical Outcomes in Laboratory Animals: A Systematic Review

Available at:https://jlar.rovedar.com/index.php/JLAR/article/view/84

#translation #applied #linguistics #language #teaching #research #language #animal_lab #animal_laboratory #google_Scholar #pkp

https://www.instagram.com/p/DSCK41ZjJlI/?igsh=MWIwdWRoY3h0d3Fpaw==

[jlareditor1]

Tuberculosis (TB) remains a major global health challenge, highlighting the need for new and complementary therapeutic methods and strategies. The present study aimed to provide a comprehensive review of medicinal plants recommended by the renowned Persian physician Avicenna (Ibn Sina) for TB treatment, focusing on their phytochemical compounds and mechanisms of action. The present study combined a historical analysis of Avicenna's Canon of Medicine to identify medicinal plants used for tuberculosis with a systematic literature review (2000-2024) to evaluate their modern pharmacological evidence.

Available at:https://jlar.rovedar.com/index.php/JLAR/article/view/83

https://www.instagram.com/p/DRtXFQrDGIo/?igsh=YnF2dGZheXhmd2tl

[jlareditor1]

Minipigs are a popular model for many organs in the translational research ecosystem due to their similarities to humans.  Minipigs develop naturally occurring periodontal disease, making them a compelling model in orofacial studies.  However, periodontal disease influences the inflammatory status, the oral and gastrointestinal microbiome, and could impact the results of studies in porcine models. The present study aimed to adapt the canine total mouth periodontitis scoring (TMPS) system for use in Yucatan Minipigs and to compare the TMPS calculated from a full mouth evaluation to a more efficient TMPS QUICKSCORE. 

Available at :https://jlar.rovedar.com/index.php/JLAR/article/view/73

[jlareditor1]

In vivo studies remain a cornerstone of biomedical, pharmacological, and toxicological studies, providing critical insights into the safety and efficacy of novel interventions. However, the reliability and translational value of such experiments are frequently undermined by methodological errors, hidden contaminations, and uncontrolled confounding factors. Poor study design, insufficient randomization, and operator-related inconsistencies introduce variability that may obscure true biological effects.

Available at:https://jlar.rovedar.com/index.php/JLAR/article/view/78

https://www.instagram.com/p/DOQod1dEUhI/?igsh=MWRqYXdoNjZxOW00dA==

[jlareditor1]

The CRISPR-Cas9 system has revolutionized genome editing, offering unprecedented precision and efficiency in gene modification. Its potential in cancer therapy, particularly oncolytic gene therapy, has garnered significant attention, especially with the development of advanced delivery platforms. However, effective and safe in vivo delivery of CRISPR components remains a major barrier to clinical translation. This review provides a comprehensive overview of viral and non-viral nanocarrier systems for CRISPR-Cas9 delivery, with a particular focus on their application in xenograft models of cancer.

Available at :https://jlar.rovedar.com/index.php/JLAR/article/view/66

https://www.instagram.com/p/DKo9xcmIGHX/?igsh=ODZiZXB1cml6YmZt

[jlareditor1]

Aframomum pruinosum seeds have been widely used in traditional medicine to treat lung infections as a cytoprotective plant-derived medicine. The present study investigated the anti-inflammatory and antioxidant effects of A. pruinosum in Wistar rats subjected to bleomycin-induced lung injury.

Available at :https://jlar.rovedar.com/index.php/JLAR/article/view/59

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