Sure thing! So far, Noelle has been playing a very feminine, "good girl"/"girl next door" role. So when she describes wanting to break free of that, particularly when playing that role "feels like watching someone else move [her] through [her] life, that resonates well with transmasc experiences. The entire disassociation angle ("looking through [her] life through glass") is also uncannily dead on on how I'd describe myself (trans man) as an egg. It's worth mentioning none of these feelings are exclusive to the weird route either; Noelle says she starting feeling like this when Dess left.
Another piece of evidence (?) is that Noelle's room is straight up the colors of the trans flag. Deltarune has used the trans flag colors multiple times to indicate transness (Kris is blue and pink, the drink voucher Ralsei wants is blue and pink, Ralsei's princess dress is a pale pink contrasted against white fur, the trans pale blue Mettaton dress is contrasted against a white Spamton mannequien, probably something else I'm forgetting), so it's unlikely to be an accident. It's also her whole ass room. Every other lightner's room is strongly indicative of their character traits, so that sure says something about Noelle!
Noelle also has a lot in common with Ralsei, who just changed their pronouns in the menu and reaaally seems to want to be a princess. They both are mages with a pacify spell who suppress their own needs to appeal to others. This is more on the speculative side, but I wouldn't be surprised if Noelle and Ralsei get a lot of interactions in chapter 6, considering they are the only two party members who haven't really interacted yet.
Next, Noelle admires Susie's unabashed individuality and is way more comfortable around Kris, noting that they are the only one who knows how weird she is. This definitely could be because Kris and Susie seem to be more openly queer than Noelle feels that she can be, but I think it's worth noting because Kris is trans and Susie is butch. That admiration and being weird like Kris fits nicely with a transmasc interpretation.
She argued with Kris on who should be festival king or queen when voting way back in the day (I also thiiiink she voted for herself as king but I cannot find the screenshot rn, I look later to see if that's true).
There's no silver bullet like for Galsei and the "Got it, princess?" scene, and Noelle could just not be a fan of the gender role she was assigned while still being a girl. But all together she's putting on a hyperfem facade, wishes she could be more like trans/butch people, has similarities to the currently-questioning egg, and has a trans flag for a room. I can't say for sure if Noelle will transition, but I think the groundwork has been laid!
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