GMP Grade High Purity Parmaceutical Intermediate API Raw Powder CAS # 83905-01-5 Azithromycin Dihydrate
Azithromycin is a semi-synthetic 15-membered macrolide antibiotic. White or quasi-white crystalline powder; odorless, bitter; slightly damp. This product is soluble in methanol, acetone, chloroform, anhydrous ethanol or dilute hydrochloric acid, and almost insoluble in water.
Basic information: Azithromycin dihydrate 83905-01-5
Product Name Azithromycin dihydrate
Synonyms AZITHROMYCIN 2-HYDRATE;1-Oxa-6-azacyclopentadecan-15-one, 13-(2,6-dideoxy-3-C-methyl-3-O-methyl-.alpha.-L-ribo-hexopyranosyl)oxy-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-3,4,6-trideoxy-3-(dimethylamino)-.beta.-D-xylo-hexopyranosyloxy-, dihydrate, (2R,3S,4R,5R,8;AZITHROMYCINDIHYDRATE(PATENTED-NOSUPPLY);1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, dihydrate, (2R,3S,4R,5R,8R,10R;1-Oxa-6-azacyclopentadecan-15-one, 13-[(2,6-dideoxy-3-C-methyl-3-O-methyl-a-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-hexopyranosyl]oxy]-, dihydrate, [2R-(2R*,3S*,4R*,5R*,8R*,10R*,11R*,12S*,13S*,14R*)]-;azithromycin hydrate;Azithromycin (100 mg);(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptaMethyl-11-[[3,4,6-trideoxy-3-(diMethylaMino)-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one Dihydrate
Product Categories Macrolides (Antibiotics for Research and Experimental Use);Antibiotics for Research and Experimental Use;Biochemistry;Carbohydrates & Derivatives;Chiral Reagents;Intermediates & Fine Chemicals;Pfizer compounds;Pharmaceuticals;SELDANE;Inhibitors
applicationFor respiratory infections, urinary tract infections, skin and soft tissue infections and sexually transmitted diseases
Chemical Properties: Azithromycin dihydrate 117772-70-0
alpha D26 -41.4° (c = 1 in CHCl3)
refractive index 47 ° (C=2, EtOH)
storage temp. -20°C Freezer
solubility Soluble in DMSO at 20mg/ml. Also soluble in chloroform or ethylene chloride
Spec. Azithromycin dihydrate 117772-70-0
ITEMSSPECIFICATIONSRESULTS
AppearanceA White or almost white crystalline powder Conforms
SolubilityPractically insoluble in water,freely soluble in
anhydrous ethanol and in methylene chloride Conforms
CrystallinityMeet the requirements Conforms
Related substancesDesosaminylazithromycin ≤0.3%DL
N-demethylazithromycin ≤0.7%0.001
Any other single impurity ≤1.0%Conforms
Total impurities≤3.0 %0.015
Residual solventsAcetone ≤0.5%0.003
Loss on drying4.0 % ~ 5.0%0.045
Residue on Ignition≤0.3%0.0004
Melting point50 °C ~ 60 °C50 °C ~ 60 °C
Heavy metals≤ 25 ppmNMT25 ppm
( calculated on the anhydrous basis)945 ug ~ 103 ug of azithromycin per mg982 ug/ mg
ConclusiionThis product complied with the standard of Enterprise/USP
TestsSpecificationResults
DescriptionWhite or almost white powderComplies
SolubilityPractically insoluble in water, freely soluble in ethanol and in methylene chloride.Complies
A)IR spectrumConforms to azithromycin RSComplies
B)Rt HPLCConforms to azithromycin RSComplies
Specific rotationBetween -45°and -49°-47.6°
CrystallinityMeets the requirementsMeets the requirements
PHBetween 9.0 and 11.010.32
WaterBetween 4.0%and 5.0%4.7%
Residue on ignitionNot more than 0.3%0.08%
Heavy metalsNot more than 25ppmComplies
AssayNot less than 945μg and more than 1030μg of azithromycin(C38H72N2O12) per mg, calculated on the anhydrous basis967μg per mg
MethanolNot more than 0.3%0.031%
EthanolNot more than 0.05%0.0068%
AcetoneNot more than 0.5%0.1475%
ChloroformNot more than 0.006%0.0037%
Temozolomide is used in the treatment of adults with refractory pleomorphic glioblastoma and anaplastic astrocytoma of chemotherapy drugs.
1.Azithromycin Dihydrate is used for acute throat and tonsillitis which are caused by streptococcus pyogenes, otitis media sinusitis acute bronchitis skin soft tissue infection which are caused by sensitive bacteria.
2.Azithromycin Dihydrate is also used for pneumonia urethritis cervicitis and so on.
Suitable for sensitive caused by the bacterium respiratory tract, skin soft tissue infection caused by the original body of garment of sexually transmitted diseases. For influenzae, pneumococci and mo draw CARDS he caused by bacteria etc of acute brochitis, chronic obstructive pulmonary disease amalgamative infection, pneumonic wait for the efficient above 90%, bacterial remoal reach 85%. For pyogenes, aureaus etc caused furuncle swollen, cellulitis wait, use this product daily 1 times 5 therapy (1.5 g), total cure for 53% ~ 74%, efficient 90%, its curative effect and the benzene thiazole Westwood, erythromycin and cephalosporins ampicillin similar. Single-agent 1g treatment for chlamydial infection, its curative effect with ciprofloxacin or doxycycline grain phase.
1. Client is first. We are trying to bring maximum profit to our clients and we only share small.
2. Credibility is the most important.
3. Quality control is our life.
4. Great sense of responsibility.
5. We will be responsible for not only our products, our clients, our suppliers, also the society
A:Of course. For most products we can provide you a free sample, while the shipping cost should undertake by your side.
A: For the high value product, our MOQ starts from 1g and generally starts from 10g.
For other low value product, our MOQ starts from 100g and 1kg.
Q3:Is there any discount?
A:Yes, different quantity has different discount.
Q4: How to confirm the Product Quality before placing orders?
A: By sending you our available free samples.Or if you have special requirement on the goods, we can prepare samples according to your requirement for your confirmation.
Q5:What's your lead time?
A:We can arrange the shipment in 3 working days after receiving your payment, except the customised products.
1.Azithromycin is used to treat or prevent certain bacterial infections, most often those causing middle ear infection, strep throat , pneumonia, typhoid, and sinusitis
2.It has used primarily to prevent bacterial infections in infants and those with weaker immune system
3.It is also effective aganinst certain sexually transmitted infections , such as non-gonococcal urethritis, chlamydia and cervicitis
4.Azithromycin cin is use for acute pharyngitis , acute tonsillitis caused by Streptococcus pyogenes
5.Azithromycin is used for acute throat and tonsilitis which are caused by streptococcus pyogenes , otitis
6.Azithromycin can treatment of mrdia sinusitis acute bronchitis skin soft tissue infection which are caused by sensitive bacteria
7.Azithromycin is also used for pneumonia urethritis cervicitis and so on.
Arshine Group is composed of 5 subsidiaries, including Arshine Pharmaceutical Co.,Ltd, Arshine Food Additive Co., Ltd, Arshine Animal Healthcare Co., Ltd, Arshine Life Science Co., Ltd and Hangzhou Arshine Branch. Arshine specializes in exporting human and veterinary API, vitamins, amino acids, minerals, food and feed additives and plant extracts etc. Arshine has exported around 2000 products to 90 countries and areas in Europe, Middle East, East Asia and South Asia. Since establishment, Arshine’s annual sales volume has increased from USD 1 million to USD 100 million, growing hundredfold in 10 years. Having established long-term cooperation with more than 800 manufacturers, Arshine is regional sales representative or even exclusive agent for many manufacturers nowadays. To our pride, Arshine ranks among top 10 in all pharmaceutical raw materials export enterprises in China, top 3 in the private exporters.
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