Gout Note large tophus on malleolus and along margin of the foot, sign of chronic gout, composed of crystalline material (H and E shows multinucleated giant cell reaction to the MSU crystals)
Hyperuricemia
Older men
Deposition of urate monophosphate crystals.
Negative birefringency, needle shaped crystals, neutrophils in joint aspiration
1° = 90%, idiopathic, 2°= 10% leukemia, polycethemia vera, renal failure, Lesch-Nyhan Sd ( HPRT1 deficiency, X linked, mental retardation, self mutilation, hyperuricemia, spasticity)
Affects: big toe (podagra, painful), heel, ankle, wrist
Big toe, very very painful, skin ulceration and joint destruction and deformity.
Complications: uric acid calculi (radiolucent), renal failure.
Tx: NSAIDs, colchicine, allopurinol (xantine oxidase inhibitor), probenecid (helps eliminate uric acid by the kidney)
Acute attack
NSAIDs: best initial tx
Steroids: Triamcinolone, oral (multiple joints) or injection (single joint). When pt doesn’t respond to NSAIDs or are CI.
Colchicine: CI of NSAIDs or steroids. SE: white cell suppression, diarrhea
If pt is already on Allopurinol, continue.
Chronic
Allopurinol: best initial tx. SE: hypersensitivity, Toxic epidermal necrolysis, Stevens-Johnson sd.
Febuxostat: if pt can’t tolerate Allopurinol
Pegloticase: for refractory disease
Probenecid, Sulfinpyrazone: rarely used
Decrease: alcohol, meat, seafood, weight.
Avoid: thiazides, aspirine, niacin. Losartan first if HTN
Colchicine: prevents second attacks
















