What are you reading rn, why are you reading it, and what format are you reading it in (physical book, ereader, on your phone etc)
Today's Document
Aqua Utopia|海の底で記憶を紡ぐ

bliss lane
let's talk about Bridgerton tea, my ask is open
noise dept.
KIROKAZE

#extradirty
Claire Keane

Love Begins
NASA
PUT YOUR BEARD IN MY MOUTH
Misplaced Lens Cap

JVL
🪼
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PR's Tumblrdome
The Bowery Presents
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@macgyvermedical
What are you reading rn, why are you reading it, and what format are you reading it in (physical book, ereader, on your phone etc)
Salicin
You ever come across a piece of information that's just "man, if I ever get thrown back in time to like the 1700s, this is really gonna come in handy."
Well I did. And I'm here to share it with you.
Most people know that there's a connection between the drug aspirin (acetylsalicylic acid) and the willow tree. Maybe erroneously that the willow tree contains acetylsalicylic acid.
It doesn't, but it does contain salicin.
Salicin is a plant hormone that is found in a ton of different plants. Those with really high concentrations of salicin include willow, poplar, meadowsweet, cramp bark, black haw, and wintergreen.
Salicin is also a crude NSAID. It blocks the inflammatory chemicals COX-1 and 2, TNF-alpha, and NF-K-beta, similar to other NSAIDs. This means it temporarily reduces pain and fever.
Note that unlike acetylsalicylic acid (ASA), salicin doesn't prevent platelets from sticking together. Salicin will do nothing for a heart attack.
Salicin also takes longer to work than ASA, because the body has to convert it from salicin to salicyl alcohol to the active salicylic acid, which can take over an hour. ASA works in about 30 minutes.
Salicin has much more significant GI side effects than ASA. Eating the whole plant material tends to attenuate this some, but extracts containing salicin are extremely hard on the stomach.
Salicin was all we had for fever for literally thousands of years, and basically the only non-opiate painkiller. It's descendant aspirin is the best selling drug of all time.
OTC Meds of the Early 1900s
You’re probably aware of the old patent medicines- everything from harmless snake oils to very real, very dangerous concoctions of cocaine, morphine, belladonna, and alcohol that were sold without regulation by people who were more showmen than pharmacists.
And, likewise, you’re probably familiar with today’s over the counter (OTC) medications- the acetaminophen (paracetamol), ibuprofen, diphenhydramine, aspirin, loperamide, bismuth subsalysate- that you would find in the local pharmacy, drug or grocery store.
But you might not be aware that there was a period in between these. Where there was some government regulation, some knowledge that you probably didn’t need (and didn’t want) morphine for your cough, but where the pharmacy knowledge wasn’t quite where it is today as far as making medicine relatively safe for consumers to purchase without a prescription.
Well I recently went to an antique mall with a whole section devoted to early OTC drug packaging, and found it absolutely fascinating. I did some research on what I found for you guys- hope you find it as interesting as I did!
Painkillers/Analgesics:
The first two are both marketed as “Laxative Cold Tablets” and contain a drug called “Acetanilide.” Acetanilide was first created in 1886, and first marketed under the brand name “Antifebrin” in 1887. It was one of the first non-aspirin, non-opioid painkillers/fever reducers available to consumers. Acetanilide is a prodrug of acetaminophen (AKA paracetamol, brand name Tylenol), meaning that while the chemical itself was not particularly helpful, the body would break it down into acetaminophen, which was responsible for the painkilling and fever-reducing effects.
Though effective, acetanilide and other similar acetamenophen prodrugs did have a significant drawback. Sometimes it would metabolize to a chemical called aniline along with acetaminophen (or aniline would be present in the drug all along due to defects in the production process). Aniline can be extremely toxic, causing a condition called methylglobinemia where the blood fails to adequately circulate oxygen. Due to this, once it was discovered that the metabolite acetaminophen could be synthesized and used without this risk, acetanilide was taken off the market.
The doses present in each tablet are measured in grains- typically 1 grain equals about 65mg. Instructions for such medications were usually to take 2 grains initially (130mg) and then 1 grain (65mg) every 3 hours as needed after that.
The term “laxative” appears in many different early OTC cold/pain medications. Oddly, the best I can find was that other ingredients were added to cause the laxative effect, not that bowel motility was a natural side effect of acetanilide. So basically people just really liked laxatives to the point where you could market your cold meds better if you made them laxatives as a perk…
The main painkiller in C-2223 is sodium salicylate- a chemical similar to aspirin that is used today primarily to treat acne topically (if you’ve ever read the bottle of an acne product and seen “salicylic acid” this is a salt version of that acid). It has all the same issues that aspirin does, including risk for bleeding, and reye’s syndrome in children. As such, the warning “not for children” on the bottle is very accurate.
Expectorants:
Along with sodium salicylate, C-2223 also contained potassium iodide. While most people know potassium iodide as a preventative against certain aspects of radiation sickness, it is also an expectorant, or drug that loosens mucous to make it easier to cough up. Potassium iodide is still available as an expectorant, but usually this is by prescription for chronic bronchitis and other longer-term respiratory illnesses. Today potassium iodide has largely been replaced by the expectorant guafenesin due to severe allergy concerns for some patients (those allergic to shellfish, iodine, or contrast media may have a life-threatening reaction).
Another expectorant, usually used in combination with potassium iodide was ammonium chloride. Ammonium chloride works by irritating the respiratory tract, which encourages it to shed liquid, which loosens secretions. Ammonium chloride can still be found in some some cough medicines, but tends to also irritate the stomach and intestines, causing prohibitive side effects.
Antihistamines/Ye Olde NyQuil:
The concept of combining a painkiller, antihistamine, cough suppressant and expectorant into one convenient package for cold and flu is not new.
This tin of Tabcin was from sometime in the late 1930s. It contains the antihistamine thenylpyramine hydrochloride, the painkiller acetophenetidin, and caffeine.
Thenylpyramine hydrochloride is a very early first generation antihistamine. It has largely been replaced by doxylamine (the sedating/antihistamine part of NyQuil) and diphenhydramine (Benadryl).
Acetophenetidin is yet another acetaminophen prodrug- with a twist. Acetophenetidin has a major side effect of being a negative inotrope. Negative inotropes decrease the strength of the heart’s contractions, and so need to be packaged with a positive inotrope (something that strengthens heart muscle contractions), like the caffeine present in this preparation in order to be useful and not cause really serious problems. The caffeine may also have helped counter some of the sedating effect from the thenylpyramine.
Rahnous capsules, meanwhile, go all out. Pyrilamine as an antihistamine (this was taken off the market in the 1970s due to demonstrated risk of liver cancer in rats), acetophenetidin as a painkiller, belladonna as a positive inotrope, extract of lobelia as an expectorant (lobelia, fun fact, contains a drug extremely similar to nicotine), sodium salicylate as another painkiller, camphor (either as another expectorant or positive inotrope, possibly a stimulant to mitigate the sedation from the antihistamine), and magnesium oxide as, you guessed it, a laxative.
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Happy Anniversary to my wonderful wife @alliemackenzie28 , who I met 15 years ago on tumblr and have been married to for 4 years now!
How thankful I am that we found each other!
What does it mean when a patient is "not protecting their airway"? I've heard this on medical shows or in fanfics, but I don't know what it means. Are they not swallowing?
Basically your brain and your muscles do a lot of work recognizing when something is going down the "wrong pipe" and stopping that from happening by coughing or closing off the airway. This prevents food, liquids, or other substances going down the windpipe instead of the esophagus- something called aspiration.
If someone is unconscious (not just asleep), or certain muscles are paralyzed, these mechanisms generally don't work. The person is then at risk for aspiration- they're not protecting their airway.
Aspiration can cause significant illness (aspiration pneumonia) or even death (choking). So if someone isn't protecting their airway, medical professionals have to do this for them by either putting them in recovery position (short term/field emergency situation) or intubating them (longer term/in a medical facility).
HIT (Health Information Technology) is what we are discussing in my Healthcare Perspectives course this week.
HIT (Homicide International Trust) was the Evil Organization(TM) that Murdoc worked for in the original 1985 MacGyver.
This has lead to wonderful misinterpretations of the questions:
How has HIT transformed the healthcare system?
How has HIT impacted population health?
Do you feel there are members of the population that may have difficulty with HIT?
And my personal favorite: How has HIT reduced health care costs?
How to Take Care of Yourself When You Have a Cold
Hi Guys. I have a cold.
Unrelated, but some of you have asked how to take care of yourselves when you're sick. Unfortunately, "how to take care of yourself when you're sick" is more of a book than a tumblr post, so I've been struggling with how to tackle it.
But in light of my stuffy nose, I felt a good start would be focusing on something that everyone experiences at some point- the common cold.
The common cold is a viral upper respiratory infection. That means a virus, usually a rhinovirus (but can also be a coronavirus, an influenza virus, or an adenovirus), infects the upper part of the respiratory tract. Adults get colds on average about 2-4 times per year. Young children get them like 3-8 times per year (not kidding). It usually takes between 8-16 hours between being exposed to a cold and showing the first symptoms, but it can be as long as 72 hours. Symptoms typically peak around day 2-3 and last 6-10 days.
Colds usually start with a sore throat and a dry-feeling nose, and progress to nasal congestion (stuffy nose), nasal discharge (snot), headache, sneezing and cough. The discharge is usually clear and watery at first, but can progress to being yellow or green. The color is just the dead white blood cells that are fighting the infection. It does not necessarily mean it's a bacterial infection, contrary to popular belief. Systemic symptoms like fever and body aches are rare.
Because it's a virus, antibiotics (which only treat bacterial infections) won't work. We also don't have any antivirals that work against the common cold. Very high doses of zinc (75mg elemental zinc per day, or about 100mg zinc oxide) have been shown to shorten colds and improve symptoms. Lower doses of zinc do nothing on their own, but combined with vitamin C they may improve the runny nose symptom of colds. Vitamin C alone, regardless of dose, does not appear to do anything to prevent or treat colds. We have done many placebo controlled trials on this.
Your main strategy with colds is to rest, control symptoms and wait them out. So this post is going to tell you how to do that.
Hydration: It's probably the last thing you want to do with a stuffy nose, but you're going to want to drink a lot of fluids. Not only are you losing a substantial amount of water through snot and breathing through your mouth (up to a liter a day, and you lose a lot more on top of that just existing, so it needs replaced), but extra water helps loosen secretions and if you decide to take an expectorant like guaifenesin, it won't work well if you're dehydrated.
Warm, sweet or salty liquids are sometimes easier to drink a lot of when you're sick than plain water. Honey as a sweetener can help soothe sore throats and is nice in tea. Bullion broth is convenient if you like broth. The important part is to drink a lot more than you normally do. Set a timer to remind yourself to drink if you need to.
Sleep: Get enough of this. Pay special attention to getting into bed on time. Raising the head of your bed can make it easier to breathe through your nose at night. If you don't have a wedge pillow, you can do this by taking a straight-backed chair, laying it on it's front on the bed with the legs pointed towards the head of the bed, covering it with pillows, and laying on it.
Humidity: Steam and humidification can soothe irritated mucosa in the nasal passages and help loosen secretions. Use a humidifier if you have one, or boil water on the stove and breathe in the steam. Sometimes a hot shower also helps a lot.
Meds: There are a lot of over the counter medications available to you to manage symptoms. It is important to note that you should never give these to a child under two, and never give these to a child under 6 without a doctor's recommendation.
Painkillers: Can help with headaches and sore throat. Your options generally are acetaminophen (tylenol/paracetamol) or an NSAID like ibuprofen or naproxen. NSAIDs are generally more effective and can help some with nasal congestion. Acetaminophen is better for headaches. If needed, you can take acetaminphen and an NSAID at the same time.
First Generation Antihistamines: Help with excess mucous production/runny nose, watering eyes, and cough. Also helpful to give you a better night's sleep if you're struggling. Options typically include diphenhydramine (Benadryl), chlorpheniramine, or doxylamine (Unisom). There isn't a lot of evidence that second-generation antihistamines like loratadine (Claritin) or fexofenadine (Allegra) do much for cold symptoms.
Decongestants: These help with nasal congestion. The only oral one that works is pseudoephedrine (there is oral phenylephrine too but it doesn't do a great job for most people), but there are a number of topical (nasal sprays) that work very well. These include phenylephrine and oxymetazoline. If you haven't tried the nasal sprays, definitely give them a shot. But generally you don't want to use them for more than about 3 days or they will cause rebound congestion when you stop. Also the nasal steroids for allergies don't do much for cold symptoms. And they're expensive.
Expectorants: Expectorants loosen mucous, so they're helpful if you are coughing up phlegm (you will get more phlegm up and then cough less). The main expectorant on the market is guaifenesin (Mucinex). This only works if you're really well hydrated.
Cough suppressants: The main medication available for this, besides first generation antihistamines, is dextromethophan. Generally you should only use this for dry coughs because you *do* want to cough up phlegm if it's in there. Taking it with guaifenesin kind of partially cancels out the benefit of the guaifenesin.
Combinations: There are a number of combination medications available for colds, and are sometimes what people think of when they think of "cold medicine". NyQuil is a popular brand. Basically, they're a mixture of the above options. They can be convenient, but relatively expensive for what they are. Plus they often have more meds in them than you actually need.
Complications: Colds on their own are generally not dangerous for most people, but they can cause secondary infections that car be more dangerous. These include:
Ear infections: Generally look for ear pain and dizziness after a cold. This can be viral (from the virus that caused the cold) or bacterial (the swelling from the cold trapped bacteria in the middle ear, causing a bacterial infection).
Sinus infections: Facial pain and drainage that is severe or lasts longer than 14 days from the start of the cold. swelling in the sinus cavities from a cold virus can trap bacteria and cause a bacterial infection of the sinuses.
Pneumonia: Cold viruses can spread to lungs and cause pneumonia. Symptoms include fever, severe coughing, and chest pain. Generally this happens in people who are very old, very young, or are immunocompromised.
Source: https://emedicine.medscape.com/article/227820-overview
Job hunt hopeful: Hi, I was laid off a month ago and in bad need of work! I hate job hunting and while I have gotten a couple interviews based on my current resume, I'm trying to change careers, so my job hunting is extra fun. If you have the energy for a curveball, I'd love the help. Full disclosure, I am expecting a callback tomorrow about one of my interviews, so this may be moot. I'll let you know if so c:
Sure, message me
Job (hunt) Offer
Something I learned recently about myself: I really like job hunting with/for other people.
I have 8 months of recent experience hunting for a job for myself. It sucked. But I learned a TON about job hunting and I want to help you by streamlining things and taking some of the suck out of it (two heads are better than one type of deal).
Completely free, not a scam, I want to job hunt with you. Because its fun for me and less stressful for you to have a partner in this. You have to be in the USA (I don't know anything about job hunting elsewhere) and over 18. I don't need your name or anything other than your de-identified (take out your name and contact info) resume and your generally commutable area.
If you're interested in having a partner on your job quest, message me. I consider this fun and I don't have many other hobbies.
I'll have some time in the next few days if anyone is interested.
Did you know that you can take acetaminophen (Tylenol/Paracetamol) and ibuprofen (or another NSAID) at the same time?*
Yes
No
*This assumes, of course, that you don't have a reason you can't take either of them separately
But yeah, they work completely differently and they aren't metabolized in a way that interacts badly.
Based on their side effects, if you have to take OTC painkillers a lot, take acetaminophen as the firstline agent and then add an NSAID like ibuprofen or naproxen if that doesn't work. Acetaminophen is better to take consistently for long periods of time, while NSAIDs tend to be more effective for a lot of kinds of pain and are less dangerous in overdose, but they cause stomach ulcers and kidney damage when taken consistently for a long time.
Attention, people with ADHD, autism, and anyone who has trouble with talking to people and keeping friends:
Hello! I'm one of you. When I was younger, I would have so much trouble having friends. I'm still not very good at it, but I will tell you what has made it better.
1. I learned the local sign language alphabet. When people are talking, my head fills up with things I want to say. I used to either interrupt people, or I would be so focused on not interrupting and waiting for my turn that I wouldn't actually listen to them.
Now, I use the sign alphabet to remember what I want to say. So if I want to talk about dolphins, I hold the D shape. I leave the remembering to my hand. This lets me listen to what the other person is saying. You could use a notepad or a phone, as long as you do it quickly.
2. I learned how to engage the other person. This is so hard. I want to ramble on and on! But people generally don't like that. They want to talk with you, not be talked at.
I would make pauses in my speech, so they could talk. I would ask questions. I wasn't very good at asking questions at first. I would say, "isn't that cool?" That doesn't give someone much to respond to. So...
3. I learned to ask open ended questions, like "What do you think about this character's choice?"
4. I learned that I needed to find common interests. I'm lucky because I can talk about a wide variety of topics. If you can't, I suggest you find clubs or forums for your special interest. You could also try to find something related to it. For example, if you like Steven Universe, and the other person is interested in gem stones, you could ask them about the real life properties of diamonds versus pearls and things.
As much as I want to talk all day about the show I just watched, I need to find someone who wants to hear it. If I'm with someone who doesn't like that kind of thing, I need to talk about something we both like. If I just met them, I can ask what their hobbies or favorite shows are, or I can ask them if they like my favorite stuff.
Sometimes I can get my friends into the stuff I'm into, but that's not always the case. And that's okay. I can open myself up to trying out things they're interested in.
How To Cool Someone Down Fast
Hi Folks. Have you heard about heatstroke? It's summer. And there're heat waves. And heatstroke is a Call-[Emergency Number]-Now type emergency.
Heatstroke is when the body's normal heat-regulating measures have failed under intense environmental heat stress. Core body temperature can rise up to 6 degrees F (3 degrees C) in as little as 10-15 minutes. And a sustained temperature of 105F (40.5C) or higher can cause severe neurological damage.
It looks like:
Confusion, altered mental status, slurred speech
Loss of consciousness (coma)
Hot, dry skin or profuse sweating
Seizures
Very high body temperature (greater than 104F (40.C))
The only way to limit the damage is to cool the person down. So once you've called that emergency number, you're gonna want to act fast.
Fortunately, the state of the art of cooling is very low tech. The following can cool a person by 0.16F (0.09C) per minute. And that's better than just about anything except ECMO. It's probably what they're going to do in the emergency department.
Get some water. Doesn't have to be ice water. Just regular water will do. Make sure the person is wearing clothes or you have to put a sheet over them. Drench their clothes or the sheet in the water. Point a fan at them and set it to it's highest setting. If you don't have a fan, get a piece of cardboard or a newspaper or something and fan them.
That's it. That's going to get the person down a degree or so by the time EMS shows up, which might save some very valuable brain.
Idk if it counts but I wish we were taught how to recognize warning signs of mental health issues that can occur later in life, or just recognizing different mental health issues in general. Not just in ourselves but friends and family too
50% of mental illness manifests before the age of 14, and 75% manifests before age 24. Because of this, teens and young adults (and people who work with and care for them) need to be able to recognize early warning signs of mental health conditions.
In kids:
Young kids usually aren't great at recognizing, identifying, and expressing emotion verbally unless they've been specifically taught to do so. So if they're in distress emotionally, it is usually shown via behavior.
Frequent temper tantrums in children who should be too old for temper tantrums
Changes in school performance
Fighting to avoid school or sleep
Frequent aggression
Nightmares
Children often have magical thinking and imaginary friends normally, so the positive symptoms (hallucinations/delusions/paranoia) of psychotic disorders are harder to identify. However, if a child is in consistent distress due to strange or bizarre fears, or their magical thinking is getting in the way of age-appropriate functioning, consider getting them checked out.
Psychosis isn't just hallucinations and delusions- it has a wide range of symptoms. Especially early on, these include:
Sudden difficulty making and keeping friends
Neglect of personal hygiene
Mood swings or appearing completely emotionally numb
Sleep and appetite disturbances
Confusion or difficulty following conversations
Flattened affect (not being able to show emotion)
First episode psychosis typically occurs in late teens through 20's (somewhat older for those assigned female at birth), but can occur in younger teens and even, more rarely, pre-pubescent children. About 75% of people will have milder symptoms or warning signs like the symptoms listed above for weeks, months, or even years before this happens.
First episode psychosis is a crucial time for treatment, as aggressive treatment can prevent future episodes. The longer someone goes without treatment (called the Duration of Untreated Psychosis, or DUP), the worse their outcomes typically are.
Wait, 50% before 14? Because I've had a lot of psychiatrists surprised I was diagnosed with bipolar at 11 or 12.
They don’t usually diagnose that early (or they diagnose a kid-specific diagnosis), that might have been what they were surprised about.
Idk if it counts but I wish we were taught how to recognize warning signs of mental health issues that can occur later in life, or just recognizing different mental health issues in general. Not just in ourselves but friends and family too
50% of mental illness manifests before the age of 14, and 75% manifests before age 24. Because of this, teens and young adults (and people who work with and care for them) need to be able to recognize early warning signs of mental health conditions.
In kids:
Young kids usually aren't great at recognizing, identifying, and expressing emotion verbally unless they've been specifically taught to do so. So if they're in distress emotionally, it is usually shown via behavior.
Frequent temper tantrums in children who should be too old for temper tantrums
Changes in school performance
Fighting to avoid school or sleep
Frequent aggression
Nightmares
Children often have magical thinking and imaginary friends normally, so the positive symptoms (hallucinations/delusions/paranoia) of psychotic disorders are harder to identify. However, if a child is in consistent distress due to strange or bizarre fears, or their magical thinking is getting in the way of age-appropriate functioning, consider getting them checked out.
Psychosis isn't just hallucinations and delusions- it has a wide range of symptoms. Especially early on, these include:
Sudden difficulty making and keeping friends
Neglect of personal hygiene
Mood swings or appearing completely emotionally numb
Sleep and appetite disturbances
Confusion or difficulty following conversations
Flattened affect (not being able to show emotion)
First episode psychosis typically occurs in late teens through 20's (somewhat older for those assigned female at birth), but can occur in younger teens and even, more rarely, pre-pubescent children. About 75% of people will have milder symptoms or warning signs like the symptoms listed above for weeks, months, or even years before this happens.
First episode psychosis is a crucial time for treatment, as aggressive treatment can prevent future episodes. The longer someone goes without treatment (called the Duration of Untreated Psychosis, or DUP), the worse their outcomes typically are.
Would you mind sharing a little about your job, and what it's like to work in addiction medicine? Who are your patients, what needs of theirs are and are not being met, and what should you know if you want to work with them?
Sure!
I love my job. It's not super glamorous or difficult (most of it is judging whether someone is safe to take their dose of methadone, and then dispensing that dose), but I get to interact with a lot of people who are really doing their best and striving to do better.
I once talked with someone who worked in behavioral health, and she said she liked it because even though her program had it's revolving door just like everywhere else, you really do get to see people get better. And addiction med is no different. You see people go from desperate living situations (unhoused and unemployed, at odds with family and friends and using illicit substances every day) and missing a lot of days in the clinic, to housed and employed with steady relationships, not using, and getting a month's worth of take-home doses and even tapering off if that is what they want. It takes a long time sometimes, but methadone treatment has a pretty high success rate.
The patients that our clinics serve are mostly people that use fentanyl. True to the general population of the area, they are mostly white, Hispanic, or indigenous. A number of them, especially those early in treatment, are unhoused, and most have mental health problems in addition to their substance use disorder, and my company also provides mental health services.
People with severe opioid use disorder generally have high social needs, and to help meet these needs we employ peer support specialists. Peer support specialists are people who have substance use disorders themselves, who have been in remission for a certain amount of time, and whose job it is to connect people with services for housing, food, phones, jobs, etc...
Even so, we can't do everything. Primary care and other health needs can't really be met in our clinic, and most people have pretty significant health problems due to (or partially causing) their substance use.
One thing to know if you are interested in treating substance use is that there are a lot of rules around it in the US. Both for the clinics and programs that provide treatment, and for the patients. And you have to have really strong boundaries and be comfortable enforcing rules. It's not like this everywhere (Europe, for example, is a lot more flexible on methadone prescribing), but it is incredibly rule-heavy in the US.
Does the prodrome period have an average length before that initial episode?
I have most or all of the symptoms you gave for examples at times, and have had them for a long time. 8-10 years at least, possibly up to 12-13. I'm an age that this is a large chunk of my lifetime.
I feel like I'm probably the second third, but is it something I should particularly keep an eye on, just in case?
( @glimzreplies )
The prodrome can last years, and if you're still in the 13-30 age range definitely still keep an eye on symptoms and if things are getting worse. Also if you're having symptoms that suck for you (especially hallucinations/delusions/paranoia), there are treatments available even if you haven't had a first episode of psychosis.
You guys really liked the electrolyte drink mix.
I'm full of low resource med tips like that and I'd love to share more, but I don't know what would be helpful.
What else do you want to know how to do?