teachers now lament that students can't read anymore, not even short articles, and how the judge and jury of the future are nonexistent. which means us spite-driven writers and insatiable fic readers both tackling 300k stories (instead of using bot summaries) will save the world. which also means extremely horny fandoms will take over entire legal systems and journalism #getready
For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again
"For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again tomorrow.
That routine just changed.
On March 26, 2026, the U.S. Food and Drug Administration approved Awiqli (insulin icodec-abae), developed by Novo Nordisk, as the first and only once-weekly basal insulin ever approved for adults with type 2 diabetes in the United States.
This is not a minor update to an existing drug.
It is the first entirely new class of basal insulin to reach U.S. patients in more than two decades.
Instead of injecting insulin every single day, people with type 2 diabetes using Awiqli will only need one shot per week, on the same day, every week.
That means reducing from 365 injections a year down to just 52.
For anyone who has ever felt the weight of that daily ritual — the anxiety of forgetting, the physical discomfort, the constant reminder that their body needs help — this approval represents something much bigger than a dosing schedule.
It represents relief.
How the Drug Actually Works
Understanding why this injection lasts a full week requires a quick look inside the body.
Most traditional basal insulins are absorbed into the bloodstream and begin breaking down within 24 hours, which is why patients need a fresh dose every day to maintain stable blood sugar levels.
Awiqli works differently.
Its active ingredient, insulin icodec-abae, is engineered to loosely attach to a blood protein called albumin, which is found naturally and abundantly in the bloodstream.
This attachment creates a slow-release reservoir.
Instead of flooding the system and fading fast, the insulin releases gradually and consistently over an entire seven-day period, keeping blood sugar in a healthy range around the clock...
The FDA reviewed and ultimately declined to approve it for people with type 1 diabetes, citing concerns about a modestly increased risk of hypoglycemia in that population specifically.
Some regulatory agencies in other countries, including the European Union, Canada, Australia, and Japan, have approved Awiqli for both type 1 and type 2 diabetes, but for now the U.S. approval is limited to type 2...
What Comes Next
Awiqli is not standing alone in this space for long.
Eli Lilly is developing its own once-weekly basal insulin, called efsitora alfa, which is currently in late-stage clinical trials.
If that drug also earns FDA approval, it would give patients and doctors two once-weekly options to choose from, allowing for personalized decisions based on a patient’s health profile, insurance coverage, and individual response.
The broader direction of travel in diabetes care is unmistakable.
Fewer injections, smarter formulations, and better integration with digital tools like continuous glucose monitors and insulin-tracking apps are all converging toward a future where managing diabetes requires less daily mental effort without becoming any less medically precise...
A Small Shot With Large Implications
It is easy to look at a once-weekly injection and see only a scheduling change.
But the science behind Awiqli, the scale of the ONWARDS trials, and the consistent satisfaction reported by patients all point toward something that matters far more than convenience.
Diabetes management has always asked a lot of people.
It asks for daily vigilance, daily discipline, and a daily willingness to confront one’s own condition, sometimes in uncomfortable or inconvenient circumstances.
Anything that reduces that load, without reducing the quality of care, is worth taking seriously.
For the more than 37 million Americans living with diabetes, and the hundreds of millions more around the world, a simpler weekly routine could mean the difference between a treatment plan that works on paper and one that actually works in a person’s life.
That is the real significance of what the FDA approved on March 26, 2026.
Not just a new drug.
A new way of keeping people healthy, one week at a time."
There's way more red tape surrounding how and when you're allowed to modify your own body than there is around how and when the president can drop bombs on other countries.
This country has been having a ten year debate about who is allowed to wear a skirt in public, but Congress didn't even have to approve a whole fucking war with Iran for it to happen.
You are not free. Your freedoms are just dangled above your head like collateral, so you don't dare interfere with all the war your taxes paid for.
One time when I was a kid a group of girls and I had to treat another student for hypothermia by ourselves because she had so many invisible health issues that the adults we asked for help didn't believe us. The student in question was actively hallucinating. When I finally ran for help the people I grabbed were slow as shit to respond, casually joking about how "dramatic" the person in question was.
The kid was picked up by an ambulance 30 minutes later.
Now as an adult working in security I get SO MANY folks- upper-middle aged mostly- coming to me to 'rat out' people they think are faking it.
I was once sent into a bathroom because a client demanded that the "fucker won't get out, so good drag them out"- I was NEVER going to do that, so I did a wellness check instead. You know who it was? A person recently released from the hospital after a car accident. They had a hole in their skull and major hearing loss. They couldn't answer the owner because they couldn't HEAR the owner.
Another time about a homeless man who got around town by kicking the ground from his wheelchair. "You know he doesn't actually need that thing, his legs work fine, it's just for pity points"- Oh, so he's not paralyzed, his wheelchair is performative? Funny story Dale, I actually know that guy, he was backed over by a truck and has chronic pain from his shattered pelvis. But sure, let's make him stand up and walk everywhere so nobody feels too bad for him and tries to help him or something.
"She doesn't need that scooter, I've seen her get out of it."
"Look how fat he is, because he just rides around and refuses to get up."
"She doesn't really need that cane- she comes here without it all the time"
Sincerely, truly, from the bottom of my heart- as someone who isn't physically disabled but hears this shit all the time- fuck off
For our 4th anniversary in June 2018, we posted a different anti-fascist action every day, partly in response to the flood of questions we get from people that want to take antifa action but aren’t sure just what to do. Each one was something we reported on at some point over the last four years and most of them are actions that anyone could pull off anywhere, no matter their age or (dis)abilities. Here’s the full, linked list for handy reference:
#1: Show ‘Em Where You Stand
#2: Table Shows
#3: Take The Streets Away From Fascists
#4: Know Your History
#5: Go Where They Go
#6: Love Football, Hate Fascism
#7: Declare An Anti-Fascist Zone
#8: Welcome Refugees
#9: Write Your Bulgarian Ambassador
#10: Cancel Their Plans
#11: Get Them Fired
#12: Go On Patrol
#13: Start ‘Em Young
#14: Keep The Fash Off The Beach
#15: Ride With Them
#16: Put On A Dance Party
#17: Know Their Signs
#18: 100 Nazi Twitter Scalps
#19: Start Training
#20: Show Some Solidarity
#21: Movie Night!
#22: Expose ‘Em
#23: Stop Deportations
#24: Write To Antifa Prisoners
#25: Raise Money For Antifa Causes
#26: Keep Your Town Nice & Clean
#27: Banner Drop
#28: Start An Anti-Racist Neighbourhood Watch
#29: Work On Yourself
#30: Read And Share
proshipper used to be "ship and let ship" until the purity bullshitters got their grubby little hands in there and decided it meant you automatically support incest or something
and reminder: it's all fictional
thought crimes aren't real
characters aren't real people, they're writing tools
I used to attend fireworks on the 4th. I have had two long term partners with early July birthdays. I participated in parades. My cat won our town pet competition for the bicentennial. There was a costume ball and you had to wear 1776 clothing and wigs. Bunting everywhere starting in May.
Nothing. I have no plans to leave town. I no longer go to mass events to avoid potential mass shooter situations and no way would I go to anything for the 250.
For all the many flaws of the tagging system on this hellsite, it is so perfect for Sending Home. A man's not dead while his name is still spoken, and what are the tags but the Overhead of tumblr? They aren't the posts themselves, but they are metacommentary on posts, notes to friends, info to be passed on. The message has been logged and is continuing to be sent on. GNU
Things don't have purposes, as if the universe were a machine, where every part has a useful function. What's the function of a galaxy? I don't know if our life has a purpose and I don't see that it matters. What does matter is that we're a part. Like a thread in a cloth or a grass-blade in a field. It is and we are. What we do is like wind blowing on the grass.
–Ursula K. Le Guin, The Lathe of Heaven
Reluctancy Waltz @mrshamill - Tumblr Blog | Tumgag
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