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Colesterolo alto non vuol dire necessariamente cardiopatia: le nuove sfide alle vecchie ipotesi
Le malattie cardiovascolari sono la principale causa di morte al mondo, rendendo la diagnosi e la valutazione del rischio una priorità assoluta. La teoria prevalente sul rischio di malattie cardiovascolari è l’ipotesi lipidica, che postula che l’aumento dell’apolipoproteina B (ApoB) e del colesterolo delle lipoproteine a bassa densità (LDL-C) siano fattori di rischio significativi che…
High cholesterol does not necessarily mean danger: the latest challenge of notions
Cardiovascular disease is the world’s leading cause of death, making diagnosis and risk assessment a high priority. The prevailing theory of cardiovascular disease risk is the lipid hypothesis, which posits that elevations in apolipoprotein B (ApoB) and low-density lipoprotein cholesterol (LDL-C) are significant risk factors that should be primary treatment targets. However, this new research…
Abstract The COVID-19 infection is associated with dyslipidemia and cardiovascular complications. The aim of the study was to determine the content of ApoA1, ApoB, and oxidized low-density lipoproteins (oxLDL) in the plasma of patients (n = 81) with COVID-19, diabetes, and cardiovascular disease (CVD). ApoA1, ApoB, and oxLDL were determined using enzyme-linked immunosorbent assay kits (Elabscience, United States). The measurements were performed at an optical wavelength of 450 nm. It was shown that the level of ApoA1 in the blood of patients with type 2 diabetes and especially with COVID-19 was significantly lower than in the blood of healthy people. Blood ApoA1 levels did not show a further decrease in patients with both COVID-19 and diabetes or CVD compared to patients with COVID-19 without concomitant diseases. It was found that the level of ApoB in the blood of patients with diabetes and, especially, with COVID-19 is significantly higher than in the blood of healthy people. Blood levels of ApoB and oxLDL are higher in patients with both COVID-19 and diabetes or CVD compared to patients with COVID-19 without comorbidities. Thus, levels of ApoA1, ApoB, and oxLDL may be promising markers of COVID-19.
Keywords: COVID-19 diabetes mellitus cardiovascular diseases apolipoprotein A1 apolipoprotein B oxLDL
