#boswellia

[didanawisgi]

Friday Hope: Frankincense (Boswellia Serrata): Inhibits Spike Protein-Activated NF-kB and MAPK Chronic Disease Pathways

Yet another rich gift of Nature, Frankincense also reduces tumor proliferation and is a potential therapeutic for acute and Long COVID.

[curiouscatalog]

From: Asiatick researches. London : J. Murray, 1801-1818

AS472 .C216 v. 9

[ayurpot]

Increase Breathing Capacity With Ayurvedic Spice Boswellia

Boswellia is an Ayurvedic spice. It promotes breathing and oral health, improves digestion, increases immunity, maintains skin health, and reduce inflammation.

[comtedemoney]

Frankincense trees—of biblical lore—are being tapped out for essential oils

The fragrant resin gifted to the newborn Jesus may be at risk of disappearing.

https://www.nationalgeographic.com/animals/2019/12/frankincense-trees-declining-overtapping/

From the article:

Most frankincense comes from about five species of Boswellia trees, found in North Africa and India, but also in Oman, Yemen, and western Africa. The trees look gnarled and knotty, like a desert bonsai. To collect frankincense, harvesters make incisions into the trunks and scrape out the oozing sap, which hardens into frankincense resin.

According to DeCarlo, the trees should be cut no more than 12 times a year to keep them healthy. But in that mountain forest in Somaliland, she counted as many as 120 incisions in a single tree. The resin that leaks out of the cuts acts like a scab, protecting the wound so it can heal. It’s the same with our bodies, she says. If you get cut once, “you’re OK, right? You put a band-aid on it …. But if you get cut, you get cut, you get cut, and you’re cut … well, you’re going to be very, very open to infection now. Your immune system is going to take a big hit trying to save you, and your immunity’s going to crash.” She adds, “It is the exact same thing with a frankincense tree.”

"[C]onsumers have to ask themselves: Are we willing to lose frankincense in a few generations? “We’ve loved frankincense for a long time,” she says. "What I don’t want to see is that we love these trees to death.”

[clinicalherbalist]

Frankincense tears. . . For a few years I was getting my frankincense directly from a family in Yemen, who were harvesting it from trees where they lived. It was the best frankincense in the world, heady and rich in fragrance and nearly miraculous as a remedy for pain and inflammation. The stuff of legend, the same as the Queen of Sheba brought to Solomon. But the political situation there went from bad to worse, and I haven’t heard from the family or been able to contact them in well over a year now. These are the last few grains of frankincense i have from them. I hope they are safe, wherever they are. Millions of people have been displaced from their homes, died in acts of war or died from disease spawned by the societal collapse. I hope that Yemen will see a better tomorrow, where the tears of sorrow can stop and the tears of frankincense can flow again. . . . . . . . . . #herbalmedicine #boswellia #frankincense #yemen #اليَمَن #عدن

[didanawisgi]

The resin of Boswellia species has been used as incense in religious and cultural ceremonies and in medicines since time immemorial. Boswellia serrata (Salai/Salai guggul), is a moderate to large sized branching tree of family Burseraceae (Genus Boswellia), ...

Abstract

The resin of Boswellia species has been used as incense in religious and cultural ceremonies and in medicines since time immemorial. Boswellia serrata (Salai/Salai guggul), is a moderate to large sized branching tree of family Burseraceae (Genus Boswellia), grows in dry mountainous regions of India, Northern Africa and Middle East. Oleo gum-resin is tapped from the incision made on the trunk of the tree and is then stored in specially made bamboo basket for removal of oil content and getting the resin solidified. After processing, the gum-resin is then graded according to its flavour, colour, shape and size. In India, the States of Andhra Pradesh, Gujarat, Madhya Pradesh, Jharkhand and Chhattisgarh are the main source of Boswellia serrata. Regionally, it is also known by different names. The oleo gum-resins contain 30-60% resin, 5-10% essential oils, which are soluble in the organic solvents, and the rest is made up of polysaccharides. Gum-resin extracts of Boswellia serrata have been traditionally used in folk medicine for centuries to treat various chronic inflammatory diseases. The resinous part of Boswellia serrata possesses monoterpenes, diterpenes, triterpenes, tetracyclic triterpenic acids and four major pentacyclic triterpenic acids i.e. β-boswellic acid, acetyl-β-boswellic acid, 11-keto-β-boswellic acid and acetyl-11-keto-β-boswellic acid, responsible for inhibition of pro-inflammatory enzymes. Out of these four boswellic acids, acetyl-11-keto-β-boswellic acid is the most potent inhibitor of 5-lipoxygenase, an enzyme responsible for inflammation.

[didanawisgi]

Abstract

Colorectal cancer is one of the most common causes of cancer-associated mortality worldwide, but it is truly a preventable disease. Both curcumin and boswellic acids are well-established dietary botanicals with potent antitumorigenic properties that have been shown to modulate multiple oncogenic pathways. Recent data suggest that the chemopreventive effects of these botanicals may, in part, be mediated through regulation of key cancer-related microRNAs (miRNA) and their downstream gene targets. Here, we investigated the antitumorigenic effects of curcumin and 3 acetyl-11-keto-β-boswellic acid (AKBA) on modulation of specific cancer-related miRNAs in colorectal cancer cells and validated their protective effects in vivo using a xenograft mouse model. Both curcumin and AKBA inhibited cellular proliferation, induced apoptosis and cell-cycle arrest in colorectal cancer cell lines, and these effects were significantly enhanced with combined treatment. Gene-expression arrays revealed that curcumin and AKBA regulated distinct cancer signaling pathways, including key cell-cycle regulatory genes. Combined bioinformatics and in silico analysis identified apoptosis, proliferation, and cell-cycle regulatory signaling pathways as key modulators of curcumin and AKBA-induced anticancer effects. We discovered that curcumin and AKBA induced upregulation of tumor-suppressive miR-34a and downregulation of miR-27a in colorectal cancer cells. Furthermore, we demonstrated in a mouse xenograft model that both curcumin and AKBA treatments suppressed tumor growth, which corresponded with alterations in the expression of miR-34a and miR-27a, consistent with our in vitro findings. Herein, we provide novel mechanistic evidence for the chemopreventive effects of curcumin and AKBA through regulation of specific miRNAs in colorectal cancer.

[supplementstips]

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