#cardiac cells

[biology-geology-beaches-india]

The Scientific Research Notes of S. Sunkavally. Years: 1986 - 1990.

Page 73.

[fatcatatheart]

Scientists Made a 'Fish' From Human Cardiac Cells, And It Swims Like a Beating Heart

With its tail flipping rhythmically from side to side, this strange synthetic fish scoots around in its salt and glucose solution, using the

[regen-med-outreach]

Deriving human cardiac progenitors cells from induced pluripotent stem cells and somatic cells

Sara Barreto

Most repair processes in the human body are done by specific cells, called progenitor cells, which produce new cells to replace the ones that have been lost (see video). Progenitor cells are present in most human tissues, and they were also identified in the heart. This discovery changed the previous belief that the heart could not regenerate and so, it gave rise to new prospects to treat cardiac disorders. However, it is difficult to get cardiac progenitor cells since they are in an organ that should not be disturbed. A way that researchers found to overcome this issue was to turn specific cells, such as induced pluripotent stem cells (iPSCs) and somatic cells, into cardiac progenitor cells.iPSCs are somatic cells (like skin cells) that were transformed to behave like the cells from the embryo. The resulted iPSCs are then instructed to differentiate into cardiac progenitor cells. It is also possible to skip the step of generating iPSCs by directly transforming somatic cells into cardiac progenitor cells (see picture). These cell-based techniques could potentially allow cardiac progenitor cells to be produced in large amounts and be used as treatments for people suffering from heart diseases. However, the mechanisms involved in the development of cardiac progenitor cells are extremely complex, making it difficult to recreate the process in the laboratory. For this reason, more research is still needed to fully understand what and how molecules, genes and signalling pathways are controlling development, and if there are other ways to improve the process.

[regen-med-outreach]

New Study Reveals Stem Cells from Young Hearts May Help Reverse the Aging Process

[regen-med-outreach]

Is it possible to make a new, fully working human heart? - by Nathalie Robinson

Instead of just treating the symptoms of damaged or diseased parts of the body, regenerative medicine aims to help heal, regenerate and create new fully functioning tissue. Scientists have already shown that they can make stem cells turn into beating heart cells but the big challenge scientists and engineers face, is arranging these cells into a fully functioning 3D organ. Watch the nature video to find out about the challenges involved in making a new human heart and how it may transform medical treatments for heart failure in the future!

[currentsinbiology]

Bioengineers put human hearts on a chip to aid drug screening

When University of California, Berkeley, bioengineers say they are holding their hearts in the palms of their hands, they are not talking about emotional vulnerability.    

Instead, the research team led by bioengineering professor Kevin Healy is presenting a network of pulsating cardiac muscle cells housed in an inch-long silicone device that effectively models human heart tissue, and they have demonstrated the viability of this system as a drug-screening tool by testing it with cardiovascular medications.

This organ-on-a-chip, reported in a study to be published Monday, March 9, in the journal Scientific Reports, represents a major step forward in the development of accurate, faster methods of testing for drug toxicity. The project is funded through the Tissue Chip for Drug Screening Initiative, an interagency collaboration launched by the National Institutes of Health to develop 3-D human tissue chips that model the structure and function of human organs.

"Ultimately, these chips could replace the use of animals to screen drugs for safety and efficacy," said Healy.

UC Berkeley researchers have created a 'heart-on-a-chip' that effectively uses human cardiac muscle cells derived from adult stem cells to model how a human heart reacts to cardiovascular medications. The system could one day replace animal models to screen for the safety and efficacy of new drugs. Credit: Photo by Anurag Mathur/Healy Lab

[eideard]

Mini hearts added to veins and used as supplemental pumps to treat circulatory problems

Mini hearts added to veins and used as supplemental pumps to treat circulatory problems

When someone has chronic venous insufficiency, it means that because of faulty valves in their leg veins, oxygen-poor blood isn’t able to be pumped back to their heart. The George Washington University’s Dr. Narine Sarvazyan has created a possible solution, however – a beating “mini heart” that’s wrapped around the vein, to help…

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[suryaray-blog]

Researchers get cardiac muscle cells to grow, repair heart attack damage

#SuryaRay #Surya Massive search finds micro RNAs that help the heart regrow. http://dlvr.it/2cGRgr @suryaray