Jul 23, 2025
Transcription factors TCF4 and KLF4 respectively control the development of the DC2A and DC2B lineages - New Study
Nature Immunology, Published online: 23 July 2025; doi:10.1038/s41590-025-02208-5 Here Zhu et al. investigate the ontogeny of type 2 dendritic cells (DC2s) in mice. Using Klf4 expression to distinguish conventional DC precursors from plasmacytoid DCs, they identify two pre-DC2 populations with their development controlled by TCF4 and KLF4 that give rise to DC2A and DC2B cells. Summary Zhu et al.…