#donated organs

[girlactionfigure]

The family of Jonathan Isaac, who was killed in Gaza while defending Israel, donated his organs, saving the lives of six people, including a baby.

May his legacy live on through the lives he saved.

Inbar Cohen - ענבר כהן

[mindblowingscience]

Antibody appears to prevent organ rejection

An antibody successfully prevents organ rejection in animals, say researchers. Next come human clinical trials.

A human-made antibody successfully prevented organ rejection when tested in primates that had undergone a kidney transplant, report researchers. The finding clears the way for the new monoclonal antibody to move forward in human clinical trials. Results of the study appear in the journal Science Translational Medicine. “Current medications to prevent organ rejection are good overall, but they have a lot of side effects,” says lead author Imran J. Anwar, a surgical research fellow in Duke University’s department of surgery. “These therapies suppress the immune system, putting patients at risk of infections and organ damage, and many cause non-immune complications such as diabetes and high blood pressure. “The push over the last 30 to 40 years has been to develop new, less toxic drugs,” Anwar says. “We are hopeful this antibody moves us closer to that goal.”

Continue Reading.

[sciencenewsforstudents]

Using chemicals to supercool donor livers tripled organs’ shelf life

Cooling organs to subzero temperatures could help them last longer, making lifesaving transplants available to more people.

A new technique to keep donor organs colder than ice cold could greatly extend the length of time that those organs are viable for transplant.

Typically, donor organs stay viable for several hours on ice at about 4° Celsius. Tissue can last even longer at lower temperatures — but below zero degrees Celsius, the formation of ice crystals risks damaging an organ and rendering it unusable. Now, using chemicals that prevent an organ from freezing at subzero temperatures, researchers have preserved five human livers at –4° C. That supercool storage system tripled the livers’ typical shelf lifefrom nine to 27 hours, researchers report online September 9 in Nature Biotechnology.

This kind of deep-chill technology “would be huge for transplantation,” says Jedediah Lewis, president and CEO of the Organ Preservation Alliance in Berkeley, Calif., a nonprofit that supports research on organ and tissue preservation but was not involved in this research.

Every year, thousands of donor organs are discarded for various reasons, including the inability to find a suitable patient close enough to receive the organ before it goes bad. If donor tissue were viable longer, doctors could get organs to patients who might otherwise be too far away, Lewis says. That could lead to more lifesaving surgeries for patients waiting for a transplant — currently more than 100,000 in the United States alone. Pushing back organs’ expiration dates could also curb the costs of private flights to rush organs between cities and allow for more flexible surgery scheduling, Lewis adds.

In the new study, researchers devised a cocktail of cryoprotectant chemicals, including trehalose and glycerol, to combat ice formation and protect cells at extremely cold temperatures. To ensure each liver was completely saturated with preservatives, the researchers administered the chemicals using a machine perfusion system. That device is basically “an artificial body for the liver” that pumps fluids into an organ in a way that imitates blood flow, says Reinier de Vries, a medical doctor and mechanical engineer at Harvard Medical School and Massachusetts General Hospital in Boston.

[eretzyisrael]

Good News From Israel

Israel's Good News Newsletter to 3rd Dec 23

In the 3rd Dec 23 edition of Israel’s good news, the highlights include:

Heroic action by Israel’s first all-female tank crews.

In clinical trials, new Israeli treatment cures liver cancer patient.

14 Israelis awarded European research grants.

Israeli pen reads handwritten text to the visually impaired.

Israeli startups improve road safety and reduce traffic congestion.

Israeli soccer players won’t take “no” for an answer.

The IDF prepare to celebrate Hannukah in Gaza.

Read More: Good News From Israel

American Israelis (and other Anglos) celebrated Thanksgiving just over a week ago. In Israel last week there was much to be thankful for - the release of many hostages, temporary respite from running to shelters, and more reports of heroic rescue actions on Oct 7, from a farmer, a foreign asylum-seeker and all-women tank crews. Please read the rest of this newsletter for many more positive news stories that we can all be thankful for. The photo of flags flying on our balcony is our personal thanks just for having the blessing and protection of our own State.

[abbloodtype]

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[abbloodtype]

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[abbloodtype]

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