#gut permeability

[thenarrativefoil]

HEY IF YOU HAVE PCOS AND GUT PROBLEMS READ THIS PAPER

guess who had an increase in gut permeability that coincided with the 14th day of my menstrual cycle!! because hormones affect the microbiota which affects gut permeability!!! FUCK

[currentsinbiology]

May be similar to what occurs with Autism...

Traumatic Brain Injury Causes Intestinal Damage

University of Maryland School of Medicine (UMSOM) researchers have found a two-way link between traumatic brain injury (TBI) and intestinal changes. These interactions may contribute to increased infections in these patients, and may also worsen chronic brain damage.

This is the first study to find that TBI in mice can trigger delayed, long-term changes in the colon and that subsequent bacterial infections in the gastrointestinal system can increase posttraumatic brain inflammation and associated tissue loss. The findings were published recently in the journal Brain, Behavior, and Immunity.

“These results indicate strong two-way interactions between the brain and the gut that may help explain the increased incidence of systemic infections after brain trauma and allow new treatment approaches,” said the lead researcher, Alan Faden, MD, the David S. Brown Professor in Trauma in the Departments of Anesthesiology, Anatomy & Neurobiology, Psychiatry, Neurology, and Neurosurgery at UMSOM, and director of the UMSOM Shock, Trauma and Anesthesiology Research Center.

“Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice” by Elise L. Ma, Allen D. Smith, Neemesh Desai, Lumei Cheung, Marie Hanscom, Bogdan A. Stoica, David J.,Loane, Terez Shea-Donohue, and Alan I.Fadena in Brain, Behavior and Immunity. Published online November 2017 doi:/10.1016/j.bbi.2017.06.018

[longhaulerbear]

From 2020.

Abstract

There is a link between high lipopolysaccharide (LPS) levels in the blood and the metabolic syndrome, and metabolic syndrome predisposes patients to severe COVID-19. Here, we define an interaction between SARS-CoV-2 spike (S) protein and LPS, leading to aggravated inflammation in vitro and in vivo. Native gel electrophoresis demonstrated that SARS-CoV-2 S protein binds to LPS. Microscale thermophoresis yielded a KD of ∼47 nM for the interaction. Computational modeling and all-atom molecular dynamics simulations further substantiated the experimental results, identifying a main LPS-binding site in SARS-CoV-2 S protein. S protein, when combined with low levels of LPS, boosted nuclear factor-kappa B (NF-κB) activation in monocytic THP-1 cells and cytokine responses in human blood and peripheral blood mononuclear cells, respectively. The in vitro inflammatory response was further validated by employing NF-κB reporter mice and in vivo bioimaging. Dynamic light scattering, transmission electron microscopy, and LPS-FITC analyses demonstrated that S protein modulated the aggregation state of LPS, providing a molecular explanation for the observed boosting effect. Taken together, our results provide an interesting molecular link between excessive inflammation during infection with SARS-CoV-2 and comorbidities involving increased levels of bacterial endotoxins.

[mission-to-dietitian]

Dr. B, RD asked if our journal club group of students for today questioned whether leaky gut is real. She said the conclusion is generally (these days) that leaky gut is a symptom side effect of something else. (e.g. IBS, anxiety, IBD, etc. could be the reason a person is having “leaky gut”)

Dr. B, RD really emphasized that leaky gut is not a disease itself, but a secondary symptom of something else (e.g. IBD, IBS, anxiety, chronic illness), and that people make money off of these types of tests (e.g. lactulose-rhamnose test, zonulin test, etc.). And you DON’T need these tests to help someone and improve their gut health.

So, don’t say to clients: “Your problem is leaky gut!” WRONG!

[clareljones]

New Post has been published on Clare L Jones

New Post has been published on http://www.clareljones.com/?p=835

What is Leaky Gut Syndrome

Leaky Gut Syndrome – What is It?

Search for leaky gut syndrome online and you will get mixed results even from top notch general practitioners. There is said to be a gray area regarding the true meaning of a leaky gut and there could be varying symptoms too.

What is a leaking gut?

The gut is the largest immune system organ and when this organ leaks, substances could move into the bloodstream causing serious complications. There is no clear reason why this happens but it could be due to intestinal hyperpermeability or it could also be due to an auto immune condition. When tight junctions in the intestine responsible for controlling what passes through the lining of the gut don’t work well, substances may leak into the bloodstream.

It is hard to pinpoint exactly what increases gut’s permeability but some specialists say that it could be due to intake of certain types of drugs, the effect of radiation therapy or food allergies.

Leaky gut syndrome plus a variety of other problems

Since little is known about what causes leaky gut syndrome, symptoms are usually shared by other  digestive system problems such as colic, abdominal pains, indigestion, gas and food sensitivities. It is recommended that people experiencing these symptoms should consult their doctors at once or seek the help of a specialist that will take their symptoms seriously.

Leaky gut treatments

Because there is little known about this condition, treatments are usually according to the symptoms that you experience. There are also specialists that advise strengthening the gut and taking alternative remedies such as probiotics and making lifestyle and diet changes.

Learn about our amazing probiotic here –  probiotics 

Most importantly, tuning into what your body tells you is a must. Do not overlook any symptom and consult your doctor early.

  image from the TheRealFoodGuide.com