Durran: Maybe I won't go to heaven, but you've never owned a pit of man-eating whales, so who's the real loser here?

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Durran: Maybe I won't go to heaven, but you've never owned a pit of man-eating whales, so who's the real loser here?
Niska: You seem familiar. Have I threatened you before?
River: Happy Crimas. It Chrimam. Merry Chrisus. Merry Chrysler.
Kaylee, smiling: How are you?
Mal: How "am" I?
[Simon, during his doctor days]
Some random patient: Do you need another stool sample, doctor?
Simon: I didn't even ask for the first one.
Jayne, throwing knives at some Alliance guards: Guns are for sissies. Real men throw knives.
The Operative: People don't trust me because I look like a villian from a 80s movie.
Badger: I'm the fucking lizard king.