Karen Wheeler supports everyone in season 1 and I really like it
She definitely feels that something is going on. She asks Mike not to hide anything from her (at this moment he is hiding El in the closet and he is actively looking for Will), asks to tell Nancy if something has happened (and something really damn happened!! between her and Steve; and something else happened - Barb died, but Nancy doesn't know about it yet; and that will lead to the situation with Jonathan). She also comes to Joyce and offers her help - "if you need anything, Ted and I are here for you." And right now she really needs help, she's looking for her son, and she won't be able to catch him alone - Hopper will come to the rescue, but it's going to be a tough road for them until they get to the collaboration.
Karengate, what if they had told her everything, then maybe nothing would have happened??
My dear has just predicted all the ships between her closest people for the coming seasons. Very good.