Brand Name: Mobic, Vivlodex, Anjeso
Tablets (Mobic): 7.5 mg, 15 mg
Capsules (Vivlodex): 5 mg, 10 mg
Injection (Anjeso): 30 mg/mL
For the relief of the signs and symptoms of osteoarthritis and rheumatoid arthritis: The recommended starting dose and maintenance dose is 7.5 mg per day. Some patients may receive additional benefit by increasing the dose to 15 mg once daily. The maximum recommended daily dose is 15 mg.
For the relief of the signs and symptoms of periarticular and polyarticular course Juvenile Rheumatoid Arthritis (JRA) in patients 2 years of age and older: The recommended oral dose is 0.125 mg/kg once daily, up to a maximum of 7.5 mg.
Pharmacology/Pharmacokinetics:
The mechanism of action of meloxicam is probably due to inhibition of cyclooxygenase resulting in a decreased biosynthesis of prostaglandins. Peak plasma levels are reached in 4-5 hours with an elimination half-life of 15-20 hours. Steady state plasma levels are reached in 5 days. Metabolism occurs mainly via cytochrome P-450 2C9 and to lesser degree CYP3A4.
Drug Interactions:
May increase the serum levels of lithium. May decrease the effects of ACE inhibitors. Cholestyramine the clearance of meloxicam. Adverse effects may increase with other nonsteroidal anti-inflammatory agents and aspirin. Use with caution in patients taking warfarin.
Contraindications/Precautions:
Contraindicated in patients hypersensitive to nonsteroidal anti-inflammatory agents or aspirin. Use with extreme caution in patients with advanced renal disease and in patients with a prior history of ulcer disease or GI bleeding. NSAIDS MAY CAUSE AN INCREASED RISK OF SERIOUS CARDIOVASCULAR THROMBOTIC EVENTS, MYOCARDIAL INFARCTION, AND STROKE. NSAIDS HAVE BEEN INVOLVED IN RARE CASES OF GI BLEEDING INCIDENTS. Use with caution in patients with liver impairment, asthma, hypertension, fluid retention, heart failure, bleeding disorders, and in the elderly. NSAIDs should be used with caution during pregnancy because they may cause premature closure of the ductus arteriosus. Pregnancy Category C.
Adverse Effects:
The most frequent adverse effects are gastrointestinal in nature and include abdominal pain, diarrhea, dyspepsia, flatulence, and nausea.
Compliance with therapy is essential, may require up to 2 weeks to see noticeable improvement in arthritic conditions.
May be taken with food or milk if GI upset occurs.
Shake suspension well before using.
Concurrent ingestion of alcohol may increase ulcerogenic effect.
Avoid aspirin or products containing aspirin without first consulting a physician.
Store in a cool, dry place away from sunlight and children.
If a dose is missed, take it as soon as possible. If it is closer to the time of your next dose than the dose you missed, skip the missed dose and return to your dosing schedule.
Contact a physician if signs of hepatic failure (fatigue, lethargy, pruritus, jaundice, upper-right quadrant tenderness, flu-like symptoms), GI ulcerations, skin rash, edema, or weight gain occur.