The iconic Nuzlocke challenge has its origins in a webcomic created by Nick Franco in 2010 called Pokémon Ruby: Hard-Mode. The common name of the challenge was derived from a recurring character in the comic, a Nuzleaf styled after John Locke from the TV series Lost.
The run depicted in the comic would fail to complete the game, losing against Champion Steven after a failed attempt to defeat his Metagross using Perish Song. Shown is the ending of the comic.
Pokémon: Hard-Mode would go on to have two continuation series, Fire Red: Hard-Mode and White: Hard-Mode. The latter's most recent update was posted in 2019.
Source: nuzlocke.com











