#ratg13

[kramlabs]

Ordered both

Inconsistent with Evolution Mug - Biosafety Now Shop

Inconsistent with Evolution Mug! High quality 15oz white gloss ceramic mug Decorated with full wrap dye sublimation Microwave & Dishwash

[kramlabs]

Ralph Baric's Description of the "Perfect Bioweapon" Sounds Awfully Similar to Sars-Cov-2

Those "HIV Inserts" in Sars-CoV-2 are not just random sequences after all

[kramlabs]

“Why only North American (lab) animals (not Chinese bats), can become both infected and ‘efficiently’ transmit SARS2?”

#4: I, Shi Zhengli, guarantee with my life that SARS2 is not related to 'my' lab

How an Asian woman's transparency became a Western man’s conspiracy

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SARS-Like Coronavirus WIV1-CoV Does Not Replicate in Egyptian Fruit Bats ( Rousettus aegyptiacus) - PubMed

Severe acute respiratory syndrome (SARS)-like WIV1-coronavirus (CoV) was first isolated from <i>Rhinolophus sinicus</i> bats and can use the

[kramlabs]

#4: I, Shi Zhengli, guarantee with my life that SARS2 is not related to 'my' lab

How an Asian woman's transparency became a Western man’s conspiracy

[kramlabs]

Scientists find genetic match between Covid and Moderna 2016 patent

The international team of researchers identified a tiny snippet of code that is identical to part of a genetic sequence patented by the US

[kramlabs]

#1: A 'consensus' sequence of SARS like events

Leading up to patient 0 in Wuhan

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Divergent SARS-CoV-2 variant emerges in white-tailed deer with deer-to-human transmission - Nature Microbiology

White-tailed deer are a potential reservoir of SARS-CoV-2 variants.

Montana Mice May Hold the Secret to Virus Spillover

Researchers in Montana are working to figure out how climate change and biodiversity affect viruses’ jump from animals to people.

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SARS-CoV-2 infection, neuropathogenesis and transmission among deer mice: Implications for reverse zoonosis to New World rodents

Coronavirus disease-19 (COVID-19) emerged in November, 2019 in China and rapidly became pandemic. As with other coronaviruses, a preponderan

[kramlabs]

Reminder:

Researchers say one in 3 trillion chance Covid developed the code naturally

Scientists find genetic match between Covid and Moderna 2016 patent

The international team of researchers identified a tiny snippet of code that is identical to part of a genetic sequence patented by the US

https://www.frontiersin.org/articles/10.3389/fviro.2022.834808/full#B10

MSH3 Homology and Potential Recombination Link to SARS-CoV-2 Furin Cleavage Site

Among numerous point mutation differences between the SARS-CoV-2 and the bat RaTG13 coronavirus, only the 12-nucleotide furin cleavage site

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7457603/

Furin Cleavage Site Is Key to SARS-CoV-2 Pathogenesis

SARS-CoV-2 has resulted in a global pandemic and shutdown economies around the world. Sequence analysis indicates that the novel coronavirus

[todaysbat]

Bat Coronavirus RaTG13

RaTG13 is a SARS-related coronavirus found in bats and is highly similar to the SARS-CoV-2 virus.

FYI: Article contains technical jargon that might be confusing or daunting (I had to reread sections a few times to understand myself)

Date of Publication: March 10, 2021

For context: RaTG13 was isolated in 2013 from the droppings of Intermediate horseshoe bats (Rhinolophus affinis) in a mining cave near the town of Tongguan in Mojiang county in Yunnan, a province in southwestern China, after three miners developed severe pneumonia the previous year. More recent research has indicated that the bat coronavirus BANAL-52, isolated from bats in Laos, may be more closely related to SARS-CoV-2 than RaTG13.

Highlights:

-RaTG13 binds to bat ACE2 receptors like SARS-CoV-2 does in humans, but it doesn't bind as strongly, meaning that bats do not typically get an infection when exposed to RaTG13 (unlike SARS-COV-2 in humans) -- article goes into further detail about the mechanics of how the two viruses bind to their respective hosts' ace2 receptors

-The largest sequence difference in genes between RaTG13 and SARS-CoV-2 is between their receptor-binding sites. Compared to RaTG13, the site of SARS-CoV-2 is more closely related to a coronavirus isolated in pangolins from Guangzhou in 2019 called pangolin SARS-CoV. This indicates that there likely was a recombination event (where two different viruses swap genetic information while infecting the same host) at some point in the evolutionary history of SARS-CoV-2 involving the pangolin SARS-CoV and RaTG13 (more recent research, as mentioned above, has put forth another possibly stronger candidate for the bat virus involved).

-That all said, there's not enough definitive proof to say that the pangolin coronavirus is the immediate predecessor to SARS-CoV-2.

-Other possibilities put forth that might have happened in SARS-COV-2's evolutionary history include the involvement of civets, the intermediary species for SARS in 2002-2003; as well as the possibility that multiple bat coronaviruses combined together; or a combination.

-There is also a video at the end of the article that I have not watched from the American Society for Microbiology on the origins of Covid19.