How fucking baller would it be if this was a reference to the loom of the Moirai?
It wouldn't be Treyarch's first foray into peppering actual mythology into the narrative. That was a prominent theme in Chaos which they seem to be wanting to canonize again. "Loom" being capitalized feels like it points to that.
The Moirai were responsible for spinning the threads of mans destiny. Clotho spun the thread, Lachesis measure the lifespan, and Atropos cut the thread. Because of this, fate and destiny are inflexible. You cannot defy what has already been written for you.
Perhaps what Verytharion is trying to say is by defying the loom of the Moirai (sometimes called the Loom of Life or the Loom of Fate), their threads will be cut permanently. That by defying the fate that's been woven for everyone, they will die trying. Which would be a really interesting way to wrap up Requiem's story where we know they die by 1993 (I think).
I don't think Treyarch is actually smart enough to be playing this kind of 4D chess here. And I know by saying all this I'm going to be so mad when it doesn't come true. This line just likely refers to how Verytharion is the weaver.













