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The Scientific Research Notes Of S. Sunkavally (years: 2002-2011).
2078-2080.
The Scientific Research Notes Of S. Sunkavally (years: 2002-2011).
1521-1522.
The Scientific Research Notes Of S. Sunkavally (years: 2002-2011).
661-663.
Synapse
Arrival of impulse at synaptic knob causes permeability to alter, and Ca2+ diffuses in
influx of Ca2+ causes synaptic vesicle to diffuse with pre-synaptic membrane, releasing its neurotransmitter out into the synaptic cleft (gap between two neurones)
transmitter attaches to receptor site on post-synaptic membrane, depolarising into the next neurone and initiating the impulse (action potential) in the next neurone
This receptor spans the whole membrane
eg acetylcholine
made up of protein sub units
2 receptor sites
when acetylcholine binds with both receptor sites, the proteins change shape - opening the channel
This allows sodium ions to diffuse through from the cleft into post-synaptic neurone
if membrane is sufficiently depolarised, action potential generated
Neurotransmitters in the cleft are quickly broken down by enzymes, their constituent parts absorbed back into neurones to be used in synthesis of new neurotransmitters