Keep Your Head Up

The present is theirs; the future, for which I really worked is mine. -Nikola Tesla

[thekilljoykyle]

Also for my mom. Merry Christmas to her!

[thekilljoykyle]

For my mom. 😘

[jesterrlavorre]

I loved so many of the cute animals on vine……

[birdfries-deactivated20200124]

this is my favorite vine comp of all time

[m--ood-deactivated20181217]

Red-eyed crocodile skinks are mini dragons

[ffdsfdfs]

This is how hurricanes start.

[woodmeat]

Please brain

Can i have some serotonin??

[d-e-l-ete-d-deactivated20181014]

My brain:

[currentsinbiology]

Remake, refill, reuse: recycling at the synapse revealed

Neurons in the brain form tangled webs of connections. Within these webs, cells communicate with each other to control motor, cognitive and other functions.

A neuron, when activated, propagates an electrical signal. But that signal cannot cross the synapse – the junction between two neurons. So, communication from one neuron to the next is accomplished by the release of tiny membrane capsules containing signaling chemicals called neurotransmitters across the synapse.

The electrical signal triggers these capsules, called vesicles, to fuse with membrane at the neuron’s pre-synaptic terminal, thereby releasing neurotransmitters into the cleft between the two cells. The neurotransmitters travel across the cleft, then activate receptors in the post-synaptic neuron, triggering an electrical signal in that next cell.

Because the neurotransmitter signal goes in one direction—from the pre-synaptic neuron to the post-synaptic one— vesicles must be re-formed for the process to continue. “Recycling is a critical process to keep synapses functional,” explains Professor Takahashi, leader of the Cellular & Molecular Synaptic Function Unit at the Okinawa Institute of Science and Technology Graduate University (OIST). In a study recently published in Cell Reports, Takahashi and his colleagues shed light on a poorly-understood part of vesicle recycling.  

More information: Manami Yamashita et al. Vesicular GABA Uptake Can Be Rate Limiting for Recovery of IPSCs from Synaptic Depression, Cell Reports (2018). DOI: 10.1016/j.celrep.2018.02.080

The process of recycling at a synapse. First, lipid membrane capsules are recovered from the pre-synaptic terminal membrane. Then, the vesicles are refilled with neurotransmitter. Credit: Okinawa Institute of Science and Technology Graduate University

[luisonte]

[league-of-extraordinarycomics]

[gunshyghosts]

😂😂😂😂😂

[towritecomicsonherarms]

[lechedemipalo]

[riverwindphotography]

[animatedamerican]

you know, it is not very often that I see a gif and experience this strong a desire to put my hand into it.

[riverlarking]

how to get out of a bad date by schmidt

[throwbackblr]

[owiddles]

I need this shit, man!

[throwbackblr]

[ambitious-mind-deactivated20180]

I need this…but not at that price

[throwbackblr]

That was actually the cheapest one 😂

[babyanimalgifs]

[fastandqueerius-deactivated2026]

WHOLESOME POST

[mexicanjesuschrist-deactivated2]

[willsmithsmackedtheshitoutofme]

Wait until they walk outside. I😭😭😭😭😭😭😭😭😭😭

[deessenoir-deactivated20190203]

Lmao “what they call that”

[facelesskinkyblackguyblog]

Bruh

[pumpkinmcqueen]

Lmbo he know dang well what it is

[hotterthanhellgothica]

😂😂😂😂😂😂😂😂😂😂😂😂😂

[maybeantonioj]

Dead he got so close to her scalp tho lmfao I’m weak

[ooweeshenadi]

Lmfao

[futureblackwakandan-deactivated]

Lmfaoooooo

[badgyal-k-deactivated20190901]

The track lmaooooo BITCHHHHH 😭😭😭

[kingrudegyalchina]

YO HOW HE GET SO CLOSE AND SHE DIDNT NOTICE ?!!

[candiikismet]

YHE TRAAAAAAAACK

[westafricanbaby]

THAT TRACK TOOK ME OUTTTTTT💀💀💀💀

[lagonegirl]

He talking about The Jellies show

I’m just glad Tyler said this at Comic-Con…  that’s the audience that needs to hear this message…

[quietlysmoking]

Couldn’t be more proud of him

[purplelittlemermaid]

I play this video a lot!

[weloveshortvideos]

[breadandflowers]

Why would you put raw chicken into a soup and have it cook in the broth and spread its disgusting pathogens and shit. That’s a chunk of a raw dead animal just floating in your soup 😷

[railroadsoftware]

that’s how…. cooking works

[shin-hero-buster]

Vegans having 0 understanding of food aside, that looks super fucking good.