The Virus Detectives: Sifting Through Genes in Search of Answers on Ebola
…And it is here that Broad scientists studying Ebola and a similar deadly disease, Lassa, send their samples, taking advantage of what the center’s manager, Andrew J. Hollinger, referred to as superfast track sequencing in their urgent work on these diseases ravaging West Africa. Those scientists receive their sequence data in about 40 hours, compared with days for the usual work.
The Ebola and Lassa group, led by Pardis Sabeti, wants to know what the viruses look like. Do they mutate while they are infecting people, possibly evading the immune system? Are some strains more deadly than others? And what about the genetics of the people who are infected? Are some people more resistant, perhaps even immune, to these viruses because of tweaks in their own genes?
The research is emblematic of a new direction in public health, which uses powerful genetic methods and applies them to entire populations.
The aim is to get a detailed picture of disease epidemiology, as the disease is happening. Armed with such data, doctors should be better able to stop epidemics and researchers can get clues to treating and preventing infections.
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