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"We have your son."

"My condolences. Please try to die quickly, his dinner's almost ready."

Scientists have created a 'living plastic' that self-destructs when the material begins to erode.

Scientists have created a 'living plastic' that self-destructs when the material begins to erode. In the composting process, the novel product breaks down within a month, compared with more traditional versions that take up to 55 days to decompose under the same conditions. The hopeful technology was inspired by the power of plastic-munching proteins, which are naturally produced by a species of bacteria discovered in 2016 at a recycling facility in Japan.

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capricorn-born

Oddly specific. Got a deposit for 6,837 today

weaselle

fuck it, i never ever do those “reblog for X, this one really works!” posts, but this one doesn’t have any of that BS, this is just straight up wishing us good things; and then the comment doesn’t even say any of that either. Zero claims on this post, all positive vibes

May you end this week feeling ever more certain of a future you’ll love

vmohlere

May you end this week feeling ever more certain of a future you’ll love

mindblowingscience

Dietary management drugs have transformed Type 2 diabetes care, but daily injection routines are challenging for some patients. A new hydrog

Materials engineers at Stanford University have developed a novel hydrogel drug delivery system that transforms daily or weekly injections of diabetes and weight control drugs like Ozempic, Mounjaro, Trulicity, Victoza, and others to just once every four months. In a new study, published Nov. 21 in Cell Reports Medicine, researchers believe that such a system will greatly improve management of both diabetes and weight, improve patient drug compliance, and help those with Type 2 diabetes improve long-term health outcomes. These drugs all work by mimicking the hormone glucagon-like peptide 1 (GLP-1). But, as good as they are at helping people manage their diets and their weight, the typical daily or weekly injections are a burden for many patients. “Adherence is one of the biggest challenges in Type 2 diabetes management,” said Eric Appel, associate professor of materials science and engineering at Stanford and principal investigator on the new hydrogel that allows the slow release of the diet control drugs over many months. “Needing only three shots a year would make it much easier for people with diabetes or obesity to stick with their drug regimens.”

#read later #Diabetes

mindblowingscience

The genetic alphabet contains just four letters, referring to the four nucleotides, the biochemical building blocks that comprise all DNA. S

The genetic alphabet contains just four letters, referring to the four nucleotides, the biochemical building blocks that comprise all DNA. Scientists have long wondered whether it's possible to add more letters to this alphabet by creating brand-new nucleotides in the lab, but the utility of this innovation depends on whether or not cells can actually recognize and use artificial nucleotides to make proteins. Now, researchers at Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego have come one step closer to unlocking the potential of artificial DNA. The researchers found that RNA polymerase, one of the most important enzymes involved in protein synthesis, was able to recognize and transcribe an artificial base pair in exactly the same manner as it does with natural base pairs.

#is that really news?#read later

mindblowingscience

Acting as the main interface between the internal and the external world, the skin is the largest and most important organ of the human body

Acting as the main interface between the internal and the external world, the skin is the largest and most important organ of the human body. It is frequently exposed to many types of physical injuries or wounds, including cuts, scrapes, scratches, infections, and ulcers. Unfortunately, as one ages, the skin becomes more frail and less capable of healing itself without help. With many countries experiencing a rapid rise in the aging population, the demand for treating such skin wounds has created a greater need for accessible and effective wound care products.

#praticidade #read later

cbirt

New AI model popEVE accelerates diagnosis of rare genetic disorders by predicting mutations most likely to cause severe disease.

A newly developed AI model called popEVE shows promising results for accelerating the diagnosis of rare genetic disorders by predicting which mutations in a patient’s genome are most likely to cause severe disease. The model was created by researchers at the Harvard Medical School, USA, and deployed on genome data from over 31,000 patients with rare developmental disorders.

Genetic testing has become an invaluable tool for diagnosing rare diseases. However, even when a patient’s entire genome is sequenced, interpreting the results can be extremely challenging. Each person has around 4-5 million genetic differences compared to the reference human genome. The vast majority of these variants are benign, while only one or two may actually be causing the disease. This creates a major bottleneck in connecting patients’ symptoms to an underlying genetic cause.

Computational prediction methods can help prioritize candidate mutations, but they struggle to compare variants between different genes on the same scale.

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cbirt

The Human Immunome Project aims to revolutionize global health through unprecedented immunology insights and datasets.

In a landmark initiative, the Human Immunome Project (HIP) commenced at a summit in La Jolla, California, bringing immunology specialists together to address the greatest problems in healthcare and develop the largest immunology dataset in history. This ambitious endeavor seeks to revolutionize our comprehension of the human immune system, with the ultimate goal of enhancing global health.

The immune system is our body’s defense mechanism against outside invaders. It resembles a big barrier with numerous defense equipment. It is a whole arsenal of genes and proteins designed to combat disease, which comprises an army of B and T-cell soldiers, antibody shields, and cytokine messengers led by Human leukocyte antigens (HLA). Understanding this complicated system is critical to developing better immunizations, therapies, and even personalized medicine based on your unique immunological fingerprint. The Human Immunome Project is presently exploring this vast environment in the hopes of discovering a path to a healthy future.

The human immunome is a complex web of genes, proteins, and cells, representing our entire body’s defense mechanisms. This advanced network coordinates a multi-layered response to pathogenic threats and accurately protects our health. At the center of the immune system are the courageous B and T lymphocytes, specialist troops capable of recognizing and killing foreign intruders. B cells produce a flood of antigen-specific antibodies, molecular shields that neutralize infections and poisons.

#resources #read later

cbirt

Discover the untold story of bile acid modifications. Explore the complex world within these seemingly simple compounds and their potential for health benefits.

Bile acids, simple molecules that live in our intestines, have long been relegated to the role of digestive workhorses, faithfully emulsifying fats for absorption. However, recent scientific revelations are rewriting the story, revealing a complex hidden world within these seemingly simple compounds. This new recognition stems from the discovery that bile acids make a remarkable difference in the hands of our gut microbes—a symphony of changes that infuses them with a surprising array of potential health benefits.

This blog dives into groundbreaking research that escapes in light of this underappreciated diversity of bile acids. With the help of this research, we can explore how our gut microbes orchestrate this complex chemical choreography and present a powerful tool scientists have developed to unlock the secrets of these modified bile acids.

Bile acids, synthesized in the liver from cholesterol, are essential for a healthy digestive system. They emulsify fats and help their breakdown and absorption. However, their impact extends far beyond the gut. These act as signaling molecules that interact with receptors throughout the body and influence functions such as metabolism, immune response, and even brain health.

#weird #read later

mindblowingscience

The first "atlas" of the human ovary could lead to lab-created ovaries and treatments to help people have biologically related children.

This deeper understanding of the ovary means researchers could potentially create artificial ovaries in the lab using tissues that were stored and frozen before exposure to toxic medical treatments such as chemotherapy and radiation. Currently, surgeons can implant previously frozen ovarian tissue to temporarily restore hormone and egg production. However, this does not work for long because so few follicles—the structures that produce hormones and carry eggs—survive through reimplantation, the researchers say.

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mindblowingscience

When a life hangs in the balance, blood transfusions can help sustain a patient – but only if the donor's blood type is a match.

When a life hangs in the balance, blood transfusions can help sustain a patient – but only if the donor's blood type is a match. A new discovery by researchers from Denmark and Sweden could help in those emergency situations, while also easing global shortages in blood supplies. The team identified a mixture of enzymes made by a species of bacteria found in our guts that can, in lab studies, transform red blood cells into the universal type O with "remarkably high efficiencies" – improving on an idea hatched 40 years ago.

#weirdtitle #read later

mindblowingscience

"What our blood test demonstrates is that it's possible to detect this disease much earlier than our current diagnostics permit."

In a study in the journal Science Advances, the researchers validated the accuracy of the blood test that identifies key biomarkers of osteoarthritis. They showed that it predicted development of the disease, as well as its progression, which was demonstrated in their earlier work. The research advances the utility of a blood test that would be superior to current diagnostic tools that often don’t identify the disease until it has caused structural damage to the joint.

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mindblowingscience

Scientists have discovered cannabidiol, a compound in cannabis known as CBD, in a common Brazilian plant, opening potential new avenues to p

Scientists have discovered cannabidiol, a compound in cannabis known as CBD, in a common Brazilian plant, opening potential new avenues to produce the increasingly popular substance. The team found CBD in the fruits and flowers of a plant known as Trema micrantha blume, a shrub which grows across much of the South American country and is often considered a weed, molecular biologist Rodrigo Moura Neto of the Federal University of Rio de Janeiro told AFP in June 2023. CBD, increasingly used by some to treat conditions including epilepsy, chronic pain and anxiety, is one of the main active compounds in cannabis, along with tetrahydrocannabinol, or THC – the substance that makes users feel high. The compound's effectiveness as a medical treatment is still under research.

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Eita

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mindblowingscience

Researchers have tested an artificial lymph node that teaches the immune system to recognize and kill cancer cells in mice.

The newly developed lymph node—a sac filled with immune system components—is implanted under the skin. It is designed to act like a learning hub and stimulator to teach immune system T cells to recognize and kill cancer cells. Lymph nodes—tiny glands throughout the body, mainly in the neck, armpits, and groin—are part of the immune systems of mammals, including mice and people. They number in the hundreds so that immune cells in one area of the body don’t have to travel far to alert the immune system to impending danger. “They are a landing spot where T cells, the immune system’s fighting cells, lay dormant, waiting to be activated to fight infections or other abnormal cells,” says Natalie Livingston, currently a postdoctoral researcher at Massachusetts General Hospital and first author of the study published in the journal Advanced Materials.

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mindblowingscience

White could be the new beige when it comes to fat cells, following the discovery of a switch that maintains the functions of adipose tissue

White could be the new beige when it comes to fat cells, following the discovery of a switch that maintains the functions of adipose tissue in mice, transforming it from a lipid-locker into a calorie-burner. Physician scientist Brian Feldman and molecular biologist Liang Li from the University of California, San Francisco carried out a number of experiments on human cell cultures and mice engineered with a switch for a gene they hypothesized regulates the maintenance of our fat. By depriving the mice of the transcription factor Klf15, the researchers were able to transform the identity of 'deep storage' white adipose tissue (WAT) into a more transient, thermoregulating form called brown adipose tissue (BAT).

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mindblowingscience

A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cel

A team led by UT Southwestern Medical Center researchers has discovered a new way that cells regulate senescence, an irreversible end to cell division. The findings, published in Cell, could one day lead to new interventions for a variety of conditions associated with aging, including neurodegenerative and cardiovascular diseases, diabetes, and cancer, as well as new therapies for a collection of diseases known as ribosomopathies. "There is great interest in reducing senescence to slow or reverse aging or aging-associated diseases. We discovered a noncoding RNA that when inhibited strongly impairs senescence, suggesting that it could be a therapeutic target for conditions associated with aging," said Joshua Mendell, M.D., Ph.D., Professor of Molecular Biology and a member of the Harold C. Simmons Comprehensive Cancer Center at UT Southwestern. He is also a Howard Hughes Medical Institute Investigator.

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mindblowingscience

Scientists have figured out a non-invasive way to determine if a transplanted organ is failing to take in a patient – no matter if it's a ki

Scientists have figured out a non-invasive way to determine if a transplanted organ is failing to take in a patient – no matter if it's a kidney, liver, lung, or heart. It's the first time that biomarkers of dysfunction have matched across multiple types of transplanted organs, and it hints at the possibility of a blood test that can diagnose early rejection in all transplant scenarios – a tool that doesn't yet exist. If more research is done, the newly identified biomarkers could even be used to differentiate between various types of organ rejection, including immune issues, inadequate blood supply, or maladaptive repairs.

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