Beckett /ˈbɛkɪt/ 20s northeast usa gender? not if i have anything to do with it (they/them) i love my gf stone butch blues is the only piece of literature that fully understands me turns out my brand™ is being bitter about the hartford whalers more than two decades later
ok sorry to double reblog BUT I just looked him up and he does these fantastic videos where he breaks down HOW he actually mimics the other artists’ styles. Like for ed Sheeran, he explains how he brings his voice forward in the mouth, while Adam Levine sings in the back of the mouth, stuff like that. It’s SO COOL, I don’t think I’ve ever seen anyone actually break down how to do this sort of thing, as a skill, instead of just treating it like a neat trick they just happen to be good at.
https://www.tiktok.com/@justinjmooremusic
whenever I see archeological remains of a human who suffered from a terrible disease that couldn’t be treated in their lifetime but could be fixed now, this wave of sorrow and mourning washes over me. a woman in the 14th century who spent her 35 years of life bent at the waist because of congenital scoliosis. a man from the 18th century who died because of a non cancerous mass on his jaw that made eating progressively more difficult. remains of a woman from the Neolithic who died in childbirth having evidence of peri-mortem trepanation on her skull.
and yet she survived to 35. and yet the physicians in his time tried to strengthen his jaw. and yet someone 4,000 years ago tried to save someone they loved from dying of preeclampsia/increased cranial pressure. we tried. we tried and we tried and we tried. we failed and we learned but we tried. that’s what makes humans so beautiful.
My mom sometimes talks about a child in her neighborhood who was born with hydrocephaly and died of it. His parents strove to keep him alive for years, but he ultimately passed after a long decline. No treatment available. No hope at all, and the parents knew it from his birth.
Several decades later my sister had an MRI, as a long shot, to try to figure out why she was sick and deteriorating with a number of symptoms that were close to being written off as anxiety. She was sent straight to the hospital for adult onset hydrocephaly. Two days later she had brain surgery to put a shunt down her neck into her stomach and drain the fluid out. (No, you cannot usually get brain surgery that fast. Yes, it was that urgent.) Recovery was long and squiggly but it happened.
I think of that boy every once in a while. The one who died. I have no doubt that treatments developed for people like him, and tested on people like him, saved my sister's life.
He never knew he made the world better. His condition was severe, he never knew much of anything, I don't think. I think if I ever track down a God or something like one, that'll be somewhere on my List of Wishes. To make sure people like him know that they helped.
I've been type 1 diabetic since I was about one and a half, and was incredibly sick. If my mother hadn't also been type 1 and recognized the signs I likely would have died.
I was born in 1982. Insulin was first given to a patient in 1922, and he survived. Before that, type 1 meant death, often very slow and agonizing. Before insulin, doctors advised a super strict "keto" diet to prolong life, and it could work for awhile - up to a year, I believe. But it was a miserable existence as the body was literally eating itself as the blood turned acidic until the patient eventually died.
60 years. Only 60 years before my birth did that procedure work for the first time. That's absolutely nothing given the span of human history and I think a lot about the people who died from it throughout time.
But yes, people tried. Healers and doctors of all sorts tried all manner of things to allow these (mostly!) kids to live. The fact that it was accomplished at all is nothing short of a miracle. The fact that I've been alive 42 years is fucking insane considering my body doesn't produce a hormone necessary for survival. If you think that doesn't blow me away on a regular basis you have another think coming. It's nothing short of a miracle.
Every medical advancement is. The amount of work that goes into it and the vast amount of luck necessary to get it right even when all the research and information is sound is just astonishing.
Thank you, humanity. Thank you ingenuity and determination to save lives and make them better. Thank you to every medical practitioner and medical researcher in existence now and through all of time. Thank you to all the people who died so I could live.
Diabetes is one of these illnesses that really throws medical history into perspective. It's so common, everyone knows someone who has it, people live pretty normal lives with it. And yet, a hundred years ago, it was an instant death sentence. And then we were able to treat people with insulin and yet - it was extremely disabling. The insulin was extracted from animal pancreas had severe side effects, even with how similar the hormones are, there is always an averse reaction to proteins from foreign species, especially during long-term treatment. Injections had to be given every few hours, at-home-tests were only available from the 70s onwards. Insulin pumps entered the market in the 80s. Genetically produced insulin - humanized insulin - was first available in the US in 1982, in many countries only around the year 2000.
In 1930, having diabetes type I would basically mean being hospital bound, being woken every few hours for regular injections.
In 1965, you'd be able to live at home and get by with a very strict diet and a few timed injections. You'd struggle with chronical side effects. Having children wasn't done - passing on your genes would be immoral, and it might not even be legal for you to marry.
In the year 2000, you'd have a device clipped to your belt that would measure your blood sugar and distribute insulin, you only need to change the needle a few times a day. You might even be allowed to join in P.E. class
In 2025, you stick on two patches that do the same thing. They're synchronized through your phone.
That wasn't fate. It's not natural development that made diabetes a common chronic illness. It was hundreds of people who cared. It was the people who created the keto diet. It was the people who came up with tests. The ones who went through different species, trying to figure out the closest analogon to human insulin. It was the people who fought in court to get genetically produced insulin approved for medical use. It was people who looked at a rare, incurable disease and said "but what if it wasn't?"
I feel like I need to share this because idk if Europeans are familiar with the presence of Aldi in the US, but at least especially in my area they’ve been growing a lot recently. Like Aldi bought out some local failing grocery chains where I live (Louisiana) and have opened Aldis in all these somewhat rural communities and small towns, which for the record I’m fine with
But as a result of this they are advertising a lot more in my area and also in many cases, the people in these areas have never been confronted with Aldi or any European grocery store. So the ads that Aldi is pushing out to its new US customer base feature a cowboy shopping at Aldi who is explaining to new Aldi customers how Aldi works. Like this cowboy is explaining you gotta put a quarter in the shopping cart and why there are very little name brands. A cowboy is how they want to reach their American customer base. They gave us a cowboy
amab/afab are useful terms in specific contexts obviously but the way people use them to just maintain the fragile mental structure they had before they knew trans people existed is so sad
there’s a common phenomenon where someone leaves the LDS church but can’t handle the lack of structure and they end up joining a different high-control group (this happens with all kinds of cults and religions but i’m ex-mormon so it’s what i know most about haha) and the obsession with agab feels very similar to me.
I will admit too, the lack of structure is fucking terrifying and i’ve never in my life felt more lost than i did the first couple years after leaving the church. So i get it. But if you don’t push through that part you’ll end up doing the exact same shit again and again and again and again and
you're not allowed to bring wireless devices into classified areas and a security guy noticed a square phone-ish shape in my pocket so he asked me to show him what it was and i had to show him my can of pocket herring :/
When my cousin's then-boyfriend texted her that he would be coming home late because he would be stopping by the department store on his way home from work, she, knowing full well that he hates going there, never buys clothes there if he can help it, and generally asks to stay home whenever she goes, knew instantly that he could only be going for one reason: To buy an engagement ring.
Practical-minded, she responded: Don't forget the coupon we got in the mail, there's a discount on rings. Ever helpful, she sent him a photo of the coupon code.
He left her on read. When he came home, he was cagey and grumbling, and when she was like "Did you remember to use the coupon" he was like, "I don't know what you're talking about, why would I be buying jewelry, etc.," not meeting her eye.
Few weeks later he took her out to dinner at a fancy restaurant, spent the entire night grumbling under his breath and shaking his head in disbelief, before going "아이씨" and pulling the ring box out of his pocket and slamming it down on the table. "How the hell did you know," he said, begrudgingly impressed.
She was like, "It's really not hard" and then was like "Did you use the coupon" and he was like "Yes I used the coupon"
For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again
For millions of people managing type 2 diabetes, mornings begin the same way — a needle, a dose, and a quiet mental note to do it all again tomorrow.
That routine just changed.
On March 26, 2026, the U.S. Food and Drug Administration approved Awiqli (insulin icodec-abae), developed by Novo Nordisk, as the first and only once-weekly basal insulin ever approved for adults with type 2 diabetes in the United States.
This is not a minor update to an existing drug.
It is the first entirely new class of basal insulin to reach U.S. patients in more than two decades.
Instead of injecting insulin every single day, people with type 2 diabetes using Awiqli will only need one shot per week, on the same day, every week.
That means reducing from 365 injections a year down to just 52.
For anyone who has ever felt the weight of that daily ritual — the anxiety of forgetting, the physical discomfort, the constant reminder that their body needs help — this approval represents something much bigger than a dosing schedule.
It represents relief.
How the Drug Actually Works
Understanding why this injection lasts a full week requires a quick look inside the body.
Most traditional basal insulins are absorbed into the bloodstream and begin breaking down within 24 hours, which is why patients need a fresh dose every day to maintain stable blood sugar levels.
Awiqli works differently.
Its active ingredient, insulin icodec-abae, is engineered to loosely attach to a blood protein called albumin, which is found naturally and abundantly in the bloodstream.
This attachment creates a slow-release reservoir.
Instead of flooding the system and fading fast, the insulin releases gradually and consistently over an entire seven-day period, keeping blood sugar in a healthy range around the clock...
The FDA reviewed and ultimately declined to approve it for people with type 1 diabetes, citing concerns about a modestly increased risk of hypoglycemia in that population specifically.
Some regulatory agencies in other countries, including the European Union, Canada, Australia, and Japan, have approved Awiqli for both type 1 and type 2 diabetes, but for now the U.S. approval is limited to type 2...
What Comes Next
Awiqli is not standing alone in this space for long.
Eli Lilly is developing its own once-weekly basal insulin, called efsitora alfa, which is currently in late-stage clinical trials.
If that drug also earns FDA approval, it would give patients and doctors two once-weekly options to choose from, allowing for personalized decisions based on a patient’s health profile, insurance coverage, and individual response.
The broader direction of travel in diabetes care is unmistakable.
Fewer injections, smarter formulations, and better integration with digital tools like continuous glucose monitors and insulin-tracking apps are all converging toward a future where managing diabetes requires less daily mental effort without becoming any less medically precise...
A Small Shot With Large Implications
It is easy to look at a once-weekly injection and see only a scheduling change.
But the science behind Awiqli, the scale of the ONWARDS trials, and the consistent satisfaction reported by patients all point toward something that matters far more than convenience.
Diabetes management has always asked a lot of people.
It asks for daily vigilance, daily discipline, and a daily willingness to confront one’s own condition, sometimes in uncomfortable or inconvenient circumstances.
Anything that reduces that load, without reducing the quality of care, is worth taking seriously.
For the more than 37 million Americans living with diabetes, and the hundreds of millions more around the world, a simpler weekly routine could mean the difference between a treatment plan that works on paper and one that actually works in a person’s life.
That is the real significance of what the FDA approved on March 26, 2026.
Not just a new drug.
A new way of keeping people healthy, one week at a time.
-via Science Aim, March 29, 2026.
why not await the dawn? @freddieandersen - Tumblr Blog | Tumgag
