Silco 05/??
Yes! It wasn't completely black yet, it was kind of grey-ish in that one spot. You'll also notice in act 1 his pupil is still round, whereas in acts 2 & 3 its degraded and become misshapen, he definitely has some degree of blindness or vision impairment with that kind of eye degradation.
You actually get a good glimpse of it when he's knocked over by Powder and staring at Vander's body. His pupil is still round, albeit larger than normal and his iris is also still round, but you can see the edges are fraying, and there is some areas of his eye that are grey-ish and not completely black yet
vs when we see him again in Acts 2 & 3, they like to really emphasize Silco's eyes so we get some pretty good glimpses of its current state, especially when he's getting his injections.
His sclera is now pretty much fully black (although there are some subtle streaks of grey and red on the sides that we see when at certain points when his eyes shift certain ways), not only that but his iris and pupil are both misshapen, indicating that the infection is spreading/getting worse. The scene where he's threatening the Chem-Barons with the toxic gas/air is actually a great scene for observing his eyes since he's so expressive throughout that bit
