Kristie Aurora Hendricksen

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We cannot have a safe model that doesn’t interact with reality and doesn’t get feedback, because it won’t be coupled with reality. But we can’t trust a model that interacts with reality unless we’re already been convinced its representations are valid and not likely to slip. This is not to conclude that the problem is unsolvable - it is just saying that the ways that model developers are coupling models to reality seems to assume we’ve solved the problem that we’re trying to fix by doing so.

Semiotic Grounding as a Precondition for Safe and Cooperative AI — LessWrong

Cooperative AI fails unless its words reliably point to the world. Unfortunately, it seems like the way models are built is assuming the pro

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Why Bitcoin can be a valid part of a corporate treasury – especially in the biotech sector

In an era of persistent inflation and volatile markets, I find myself asking an important question for biotech companies looking to preserve

Could allocating a portion of treasury cash to Bitcoin help preserve, optimize, and even extend a company’s runway and hence contribute to its success? - Christian Angermayer

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Can digital therapeutics revolutionize medicine? We are just beginning to imagine and design the future of this industry.

IDEO

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Agile Might Be Dead, But Agility Isn't

Here's how we built a strong, flexible development team -- and how you can, too.

“The word ‘agile’ has been subverted to the point where it is effectively meaningless, and what passes for an agile community seems to be largely an arena for consultants and vendors to hawk services and products.”

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The U.S. government claimed that turning American medical charts into electronic records would make health care better, safer, and cheaper. Ten years and $36 billion later, the system is an unholy mess. Inside a digital revolution that took a bad turn.

 KHN

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I feel like this is the year that artificial intelligence becomes more than just a computer science problem. Everybody needs to understand that how AI behaves is important. In the Media Lab we use the term extended intelligence. Because the question is, how do we build societal values into AI?

Joi Ito, Wired

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“NAD replacement is one of the most exciting things happening in the biology of aging,” says Nir Barzilai, director of the Institute for Aging Research at the Albert Einstein College of Medicine in New York, who has coauthored scientific papers with Guarente but is not involved in Elysium. “The frustration in our field is that we have shown we can target aging, but the FDA does not [recognize it] as an indication.”

MIT TECH REVIEW 

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The transistor was invented in 1947. Since then, computing capacity has increased exponentially. We’re improving our tools and creating knowledge at an unprecedented pace, but that trend hasn’t done much for health care. At least, not yet. Right now is the “transistor moment” for the human body. In the coming decades, health care will begin to improve at the same radical pace we’ve seen in computing.

Google Ventures: Medicine’s Transistor Moment

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There’s a growing awareness among hospital officials that the hundreds of devices they use — the crash carts, insulin pumps, heart monitors and other machines integral to daily care — are really computers connected to a network, and entirely hackable.

Health care spending billions to protect the records it spent billions to install

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Interdisciplinary work is when people from different disciplines work together. An antidisciplinary project isn't a sum of a bunch of disciplines but something entirely new - the word defies easy definition. But what it means to me is someone or something that doesn't fit within traditional academic discipline­­­-a field of study with its own particular words, frameworks, and methods.

Joi Ito

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We have a very strong belief that the ledger that nobody owns is going to be the thing that draws all of the developers and the best payment functionality, wire transfer, foreign currency exchange, and all kinds of other functionality that you can't even imagine now just like when people thought of the Internet as like oh, it's the electronic post office or whatever, well, it's not just a post office, right, that metaphor is too weak. Money is too weak a metaphor for bitcoin but we think that having a financial services platform that nobody owns that everybody can benefit from is going to be a very, very big thing as time goes on and I can give you a million, zillion examples of the kinds of things that might be built if something like that existed.

Ben Horowitz, ETL

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[...] if I was at Stanford, the two things I would probably be working on would be the crypto-currency or biohacking because that seems to be the two most exciting areas that will develop in huge ways over the next 20, 30 years.

Ben Horowitz, ETL 

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Now this is the future I want to live in. This is the future that we must build. This is the future that humanity deserves.

Aral Balkan, https://ind.ie/the-camera-panopticon/

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New companies: don’t try to eat the elephant in one bite. You will lose, quickly. Be very specific in picking a clear vertical that you can win, and create a product that people love. Not like, but love, within that vertical. Crush that vertical. Block out the noise around other things, including press (because it’s harder to write good code than it is to write a good press release), and focus solely on taking small bites at winning in the pond you’ve chosen to swim.

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Innovation no longer comes from just market pull (what people ask for) or technology push (what is invented), but also from a contextual push, through studies that deliver insights about what people might want or need in the future.

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The way some pessimists put it is that all the low-hanging fruit has been picked. I would argue that there was never any low-hanging fruit; it was always of intermediate height and the question was, were people reaching for it or not? I’m frustrated because I think technology is progressing slowly, but I’m optimistic because I think it could be going a lot better.

Technology Stalled in 1970, Peter Thiel

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