alistairs’s Titties

marty, 30, white, they/them, icon by @rickety-goose

[magebastard]

writing tag for pinned post srry

[unapologeticallygay]

Lesbians are the only hope

Pride Parade, San Francisco, California, 1970s, by Judith Shane Hoth. (source)

[m3atbuff3t]

i coul dnever be the captain of a ship. everyday id be like third lieutenant ..... do a backflip lol

[capricorn-0mnikorn]

A discovery in the muscles of long COVID patients may explain exercise troubles

Long COVID patients can experience severe energy crashes after physical exertion. New research provides clear evidence that there's a biolog

Full Transcript at the link; 3-minute listen.

Quote:

By taking biopsies from long COVID patients before and after exercising, scientists in the Netherlands constructed a startling picture of widespread abnormalities in muscle tissue that may explain this severe reaction to physical activity.

Among the most striking findings were clear signs that the cellular power plants, the mitochondria, are compromised and the tissue starved for energy.

"We saw this immediately and it's very profound," says Braeden Charlton, one of the study's authors at Vrije University in Amsterdam.

The tissue samples from long COVID patients also revealed severe muscle damage, a disturbed immune response, and a buildup of microclots.

"This is a very real disease," says Charlton. "We see this at basically every parameter that we measure."

[thatdiabolicalfeminist]

I feel insane seeing stuff like this because this research already exists for Myalgic Encephalomyelitis, a post viral condition caused by multiple types of viral infections that a LOT of people with "Long Covid" meet the diagnostic criteria for.

This article mentions that ME/CFS is a "similar complex condition" but that's DEEPLY underreporting the similarities. The phrase "post exertional malaise" (now researchers are trying to replace it but this article uses that phrase) was INVENTED for ME/CFS. It's the only known condition, before "long covid", that causes these kinds of symptoms after exertion!

It's good to know for sure that it's the same mechanisms at play when the inciting viral infection is Covid and not, for instance, Epstein-Barr or RSV, but half the time it doesn't seem like researchers are making comparisons at all, just reinventing the wheel and acting like "long covid" is a totally new phenomenon with no previous point of comparison. There are literally drugs in human trials to try to treat the mitochondrial dysfunction in ME, this dysfunction is well-established and fairly well understood and I feel insane when ppl report on long covid without mentioning that there is already a named and studied condition that accounts for this subset of symptoms!!

SOME researchers are drawing comparisons but they're largely ME researchers who everyone else is largely cignoring because of the widespread perception that ME is a fake disease for lazy women.

That same perception btw is why "graded exercise therapy" (GET), or exercise gradually increasing in intensity, cwas for years the go-to treatment despite MOUNTAINS of evidence that it makes ME patients sicker. Some end up permanently bedbound and unable to even eat or drink without a feeding tube/IV because the damage is so bad! The GET recommendation was finally changed only in the past few years in the US and the UK, and many doctors hate that they're not allowed to recommend it anymore, because they insist despite the evidence that ME/CFS is psychological and ME patients are just "deconditioned" and too lazy to do anything about it.

Now the same kind of "treatment" is being recommended for long covid patients despite evidence showing exercise is having the same kinds of cellular effects as it does in ME patients. "Taking PEM into account" sounds gentler but I'm deeply concerned about the reinvention of GET for patients who meet all the criteria for an illness that's been shown definitively to become permanently worse with GET. This mitochondrial damage is progressive in ME, and there's no reason to believe patients who meet all the criteria of ME after Covid won't experience the same progression if they force themselves past their energy envelope in such a systematic way.

The additional finding that T cells — part of the immune system's arsenal — had infiltrated the muscles of long COVID patients also caught Iwasaki's attention, possibly indicating "an autoimmune response within the muscle cells."

This autoimmune response is well-researched for ME. Every time you overexert, you're injuring your cells more and more. It's deeply worrying that rebranded GET is being recommended for long covid patients who meet the criteria for ME when research like this study keeps showing it's the same phenomenon.

[ostolero]

I have three beverages advising me at all times

[fa3ryb0t]

goodbye straight people

[depsidase]

[displeasedwolf]

this is the vibe i bring to the party actually

[brucespringsteencomments]

[asystolle]

Jess & Luke in GILMORE GIRLS 2.05 | Nick & Nora, Syd & Nancy

[pussyhoundspock]

The thing people don't understand is how serious I am about clark and lex. Like I do think they were in love in the CWs smallville it is not jokes. I think they loved each other and they wanted each other and they still got divorced seventeen times anyway.

[abdalsalam-2000]

It seems that the Tumblr team has no other purpose than to delete, close, and attack the accounts of transgender people and Palestinians trying to survive genocide and ethnic cleansing in Gaza.

[abdalsalam-2000]

Two days ago, I was shocked to find that my blog, abdalsalam2000, had been deleted without warning and without me having done anything wrong, simply because I was asking for help from the Tumblr community. That blog was our only source of income that kept us alive in Gaza, and unfortunately, it was deleted by Tumblr employees.

[abdalsalam-2000]

In Gaza, we need at least $300 a day just to survive. After Tumblr deleted our account, this blog is all I have left. I hope you will help me by sharing this post, donating, and following this blog. Please, please help us and donate now.

[sporesgalaxy]

Please help Nader regain his followers and the momentum he had before his previous blog was deleted. Please donate to him now and follow his blog.

[abdalsalam-2000]

Friends, please donate now! Your help is our only hope for survival. Please share this post widely and donate here now, please!

[sillysymbol]

please donate to and share naders campaign!!

[charl0ttan]

please help nader survive!

[punkitt-is-here]

If you can give anything it helps a ton!

[abdalsalam-2000]

Hey everyone, the last donation was two days ago, and this post has been shared by almost 400 people, yet not a single person has donated. I'm begging you to share this post and donate now. Please don't leave us alone, and don't hesitate to donate. Please!

[creepish]

do you ever just sit and realize how insane people have acted towards you

[willgrahamscock]

I spent 30 years as an email draft

[theheartmold]

Support jules

Support jules

PayPal: [email protected]

hi guys could just use some help with gas money :’) I’m supposed to finish paying off my tires this month so things should loosen up for me financially soon . I also now offer sketches on my kofi so you can get something in return for a donation!

[theheartmold]

hi so my dad took what would've been my money for my tire payoffs bc my toll tag ran out (and didn't notify me). :') i have $30 to my name for the next two weeks so. uh . anything helps

[kosmogrl]

[magebastard]

damn sometimes i wonder how the show reconciles grumpy arrogant recluse depressed pervert s1 fox mulder with sitcom goofball s5 onward mulder and i do think. what with scully and all. it does make sense and work to me

[magebastard]

truly so funny (horrid lmao) that they make mulder do the I know why you can’t conceive reveal twice because they must have truly forgotten emily as an episode by s8