Okay, but the thing with Perry and Doof becomes a lot funnier when you remember that Perry, being a platypus, is immune to the virus.
So imagine Doof monologuing over Zoom, secure in the knowledge that Perry the Platypus can’t possibly thwart him over a video call, when Perry disappears from the frame. As he ponders where his nemesis could have gone, Perry plummets onto Doof’s balcony and socks him one in the jaw.
Doof: What?! Perry the Platypus?! What are you doing? You shouldn’t be out here! There’s a quarantine going on, in case you haven’t noticed!
Doof: Oh, right, you’re a platypus, and this is a human virus, so… You know, I don’t really know how I forgot that.