#antiandrogens

[medicomunicare]

Guerra al cancro prostatico resistente: esplorando la genetica per tagliare le forze alla chimera

Guerra al cancro prostatico resistente: esplorando la genetica per tagliare le forze alla chimera

Il cancro alla prostata è il tumore riproduttivo più comune tra gli uomini. I tumori della prostata rimangono localizzati nella maggior parte dei casi, offrendo agli individui affetti buone possibilità di sopravvivenza. Tuttavia, circa il 20% dei pazienti sviluppa un cancro alla prostata metastatico incurabile. Molti pazienti possono vivere lunghe vite grazie alla diagnosi precoce e al…

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[medicomunicare]

Stubborn prostate cancer: looking for new strategies against the receptAR to erase the Rsk of resistance

Stubborn prostate cancer: looking for new strategies against the receptAR to erase the Rsk of resistance

Prostate cancer is the most common cancer among men. Many patients can live long lives due to early detection and treatment with androgen deprivation therapy. Androgen deprivation therapy has been the mainstay of prostate cancer treatment for decades. The goal of this therapy is to reduce the levels of androgens that stimulate prostate cancer cell growth through either surgical or medical…

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[medicomunicare]

Ormoni maschili e melanoma: come gli antiandrogeni potenziano targeted-therapy e immunità

Ormoni maschili e melanoma: come gli antiandrogeni potenziano targeted-therapy e immunità

Il recettore degli androgeni (AR-alfa) è un tipo di recettore nucleare attivato dall’ormone sessuale maschile testosterone. Le femmine hanno livelli più bassi di androgeni, incluso il testosterone, mentre gli estrogeni sono i principali motori o la loro biologia. Un’influenza degli ormoni steroidi nel cancro è nota da decenni ormai, oltre al loro ruolo nei tumori riproduttivi (es. cancro al seno,…

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[tmitransitioning]

Hi there, I was wondering if you could tell me/direct me to somewhere that can give me an extensive kind of overview on what oestrogen does, it’s side effects etc. I’ve found a few bullet points here and there but everything always ends up leading back to testosterone, don’t get me wrong I’m thrilled transguys have all these resources but I haven’t been able to find any of my own? Thanks a bunch, hope all the mods are well

The location-specific info (prices, brand names) likely won’t be applicable, but here’s a good overview from Trans Care BC; it’s still bulletpointed but reasonably comprehensive and links to an extra video at the bottom of the “Effects” tab. This brochure might also be helpful and goes into more detail—again, it’s out of BC, so specifics about pricing and wait times etc. may not be applicable; it was also released prior to the latest WPATH Standards of Care, and while as far as I can see the information on estrogen’s effects/timeline/risks is still accurate I don’t think that the same procedures apply for routine checkups anymore (particularly, I can’t imagine why your GP would need to measure breasts/testicles unless you as the patient were specifically concerned about something related to either).

- Mod Wolf

[tmitransitioning]

Hi. I know this blog is for trans women but Im a cis woman suffering from severe hirsutism. I know you guys take meds that seems really effective for body hair do you think that would be safe for me to use. The meds I use right now aren’t that great but at the same time that’s the only thing I have for my case. Any method or advices is welcomed help

So I don’t know a ton about hirsutism, but as I understand it the treatment generally involves an antiandrogen. Stubborn hairs that won’t go away after removing androgens from one’s system can often be dealt with by permanent hair removal procedures like laser hair removal and electrolysis.

Not knowing about your specific case I’d also urge youy to give it some time. My situation is different than yours, but I started AAs and it took about a year before the pattern of my body hair changed. I’d also talk to your doctor about concerns and expectations you’re having to make sure you’re on the right treatment plan.

-Mod Shelley

[tmitransitioning]

How can I transition (mtf) without hormones? I have the BCRA 1 gene mutation and my doctor wont prescribe HRT due to my massive risk of breast cancer. I'm kinda losing hope and need something.

That’s a difficult situation. There are ways you can transition without hormones, but nothing that would work like HRT. Laser hair removal can remove unwanted body and facial hair. A good skincare routine might soften the skin some. A doctor might be willing to prescribe anti-androgens, but not estradiol (this is usually unwise as it can cause loss of bone density over time). Cosmetic surgeries are numerous and pretty much instantly effective.

First though you should talk to your doctor about options. You might be able to go on HRT, stay on it, and have regular breast cancer screening like any other person with breasts and that gene, or have a preventative mastectomy once breast growth stops. I’ll attach links to two papers describing transition by trans women with BRCA1&2 that you might be able to show your doctor show your doctor.

Your situation is difficult, but far from hopeless.

A Trans-Feminine Youth with a BRCA1 Mutation: Case Study

Hormonal and Surgical Treatment in Trans‐Women with BRCA1 Mutations: A Controversial Topic

[tmitransitioning]

is there any way to stop an amab person's body producing testosterone without an orchiectomy?

Permanently, not that I’m aware of. There is a subset of antiandrogens used in HRT for AMAB people that are called “androgen synthesis inhibitors”; while a lot of these exist, the ones used in this context are gonadotropin-releasing hormone (GnRH) antagonists. These reduce secreted testosterone levels themselves, rather than just blocking androgen receptors like other antiandrogens do; they’re also used in treating prostate cancer, and are sometimes referred to in medical literature as “chemical castration”, which is... a complicated term with a lot of history behind it that I would advise immense caution for practically every trigger under the sun if you decide to look it up.

The reason that androgen receptor inhibitors are more commonly used in HRT for AMAB people is because the most commonly available GnRH antagonist, Lupron (which you might be familiar with if you’ve read about puberty blockers!), will also reduce the production of estradiol. AR inhibitors don’t do this, they just prevent your body from hearing the signals that testosterone is sending and trick it into thinking that there’s less of it around in the first place.

- Mod Wolf

[zero-crossing-point]

im glad at least a couple of ppl bought my new album cuz it let me have enough in my paypal to buy a shit ton of loose spearmint tea cuz woo antiandrogens