#antitumour

[biomedres]

Beneficial Effects of Collagen Hydrolysate: A Review on Recent Developments

Beneficial Effects of Collagen Hydrolysate: A Review on Recent Developments by Bo Li in Biomedical Journal of Scientific & Technical Research (BJSTR) https://biomedres.us/fulltexts/BJSTR.MS.ID.000217.php

[dr-afsaeed]

T cell-derived extracellular vesicles promote antitumour immunity through horizontal gene transfer - Immunology Research

The poor immunogenicity of many tumours results in part from their downregulation of the antigen processing and presentation (APP) machinery, including MHC molecules, in both tumour cells and tumour-associated dendritic cells (DCs). Extracellular vesicles (EVs) — membrane-bound nanoparticles released by living cells that contain protein, lipids and nucleic acids — have been shown to facilitate…

[dr-afsaeed]

T cell-derived extracellular vesicles promote antitumour immunity through horizontal gene transfer - Immunology Research

The poor immunogenicity of many tumours results in part from their downregulation of the antigen processing and presentation (APP) machinery, including MHC molecules, in both tumour cells and tumour-associated dendritic cells (DCs). Extracellular vesicles (EVs) — membrane-bound nanoparticles released by living cells that contain protein, lipids and nucleic acids — have been shown to facilitate…

[dr-afsaeed]

HBx hijacks the miR-19a-3p/BAMBI/TGF-β1 axis to impair the anti-tumour activity of CD4+ T cells in diffuse large B-cell lymphoma - Research

Background: Hepatitis B virus (HBV) is clinically associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), while cellular communication in the tumour microenvironment (TME) is recognized as a critical driver of tumour progression. Nevertheless, whether HBV infection mediates DLBCL cell-immune cell crosstalk remains undefined, with the precise mechanisms and associated key…

[dr-afsaeed]

HBx hijacks the miR-19a-3p/BAMBI/TGF-β1 axis to impair the anti-tumour activity of CD4+ T cells in diffuse large B-cell lymphoma - Research

Background: Hepatitis B virus (HBV) is clinically associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), while cellular communication in the tumour microenvironment (TME) is recognized as a critical driver of tumour progression. Nevertheless, whether HBV infection mediates DLBCL cell-immune cell crosstalk remains undefined, with the precise mechanisms and associated key…

[dr-afsaeed]

Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape - New Study

Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape Summary Neoadjuvant immunotherapy in melanoma is revealing crucial insights into anti-tumor immunity and tumor escape mechanisms. Pre-treatment tumor samples allow for detailed analysis of immune cell infiltration and T-cell receptor clonality, providing a baseline understanding of…

[dr-afsaeed]

Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment - New Study

Targeting MondoA–TXNIP restores antitumour immunity in lactic-acid-induced immunosuppressive microenvironment Summary Cancer cells often produce high levels of lactic acid, creating an immunosuppressive microenvironment. This study investigates targeting the MondoA-TXNIP pathway in this lactic acid-rich environment to restore anti-tumor immunity. Researchers found that lactic acid upregulates…

[dr-afsaeed]

The liver metabolizes dietary galactose to fuel antitumour T cell immunity - New Study

The liver metabolizes dietary galactose to fuel antitumour T cell immunity Summary Dietary galactose, often overlooked, plays a crucial role in fueling anti-tumor T cell responses, particularly when metabolized in the liver. The liver’s efficient galactose metabolism pathway provides T cells with essential energy and promotes their cytotoxic activity against cancer cells. This process enhances T…